Abstract: Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo.

Abstract: The present disclosure provides a system for processing ultramafic material. The system may comprise a reactor for accelerating weathering of said ultramafic material. The reactor may comprise one or more chambers comprising one or more microbes, biological medicators, or enzymatic accelerants to facilitate the weathering of the ultramafic material.

Abstract: Circular RNA, along with related compositions and methods are described herein. In some embodiments, the inventive circular RNA comprises group I intron fragments, spacers, an IRES, duplex forming regions, and an expression sequence. In some embodiments, the expression sequence encodes an antigen. In some embodiments, circular RNA of the invention has improved expression, functional stability, immunogenicity, ease of manufacturing, and/or half-life when compared to linear RNA. In some embodiments, inventive methods and constructs result in improved circularization efficiency, splicing efficiency, and/or purity when compared to existing RNA circularization approaches.

Abstract: Circular RNA, along with related compositions and methods are described herein. In some embodiments, the inventive circular RNA comprises group I intron fragments, spacers, an IRES, duplex forming regions, and an expression sequence. In some embodiments, the expression sequence encodes an antigen. In some embodiments, circular RNA of the invention has improved expression, functional stability, immunogenicity, ease of manufacturing, and/or half-life when compared to linear RNA. In some embodiments, inventive methods and constructs result in improved circularization efficiency, splicing efficiency, and/or purity when compared to existing RNA circularization approaches.

Abstract: Disclosed herein are circular RNAs and transfer vehicles, along with related compositions and methods of treatment. The circular RNAs can comprise group I intron fragments, spacers, an IRES, duplex forming regions, and/or an expression sequence, thereby having the features of improved expression, functional stability, low immunogenicity, ease of manufacturing, and/or extended half-life compared to linear RNA. Pharmaceutical compositions comprising such circular RNAs and transfer vehicles are particularly suitable for efficient protein expression in immune cells in vivo. Also disclosed are precursor RNAs and materials useful in producing the precursor or circular RNAs, which have improved circularization efficiency and/or are compatible with effective circular RNA purification methods.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting object-based security features for use with messaging services in an application server environment. Credentials can be associated with a JNDI initial context or a JMS connection instead of a thread. For JNDI operations, a lookup call from the initial context can use a security subject in an initial context regardless of a security subject attached to a current thread of the lookup call. For JMS operations, the object-based security model can be enabled on a JMS connection factory, which is used to create a JMS connection associated a security subject based on credentials supplied to create the JMS connection. The JMS connection performs a plurality of JMS operations on different threads using the security subject. The object-based security model is automatically enabled for JMS connection operations once the JMS is accessed using an OBS-enabled JNDI context.

Abstract: A vehicle comprises a processor programmed to: responsive to detecting a predefined event, transition a plurality of vehicle systems from a normal mode of operation to a quiet mode of operation, the transition including to adjust vehicle exhaust setting to a quiet mode, engage active noise cancellation, close vehicle windows, and adjust vehicle suspension to a predefined suspension mode.

Abstract: In accordance with an embodiment, a system and method provides a messaging service implementing a unit-of-order guarantee in a multitenant application server environment. The system and method of implementing unit-of-order utilizes an improved path service for routing all messages having a particular unit-of-order to the same member of the cluster. The improved path service allows for scalability of the cluster and reduced resource utilization, thereby improving the performance of a clustered computing system providing the messaging service.

Abstract: A multi-port communication device having a plurality of serial interfaces and a plurality of Transmission Control Protocol (TCP) interfaces is provided. Data is received from one or more medical devices at a serial interface of the plurality of serial interfaces and communicated to a healthcare information system via a TCP interface of the plurality of TCP interfaces. The multi-port communication device can be remotely managed by a remote device via a set of management tools. In embodiments, the set of management tools run locally on the multi-port communication device. The multi-port communication device may additionally comprise locally installed drivers that enable communication with the healthcare information system via TCP.

Abstract: A method is provided for providing services gateway configuration data. The method includes receiving, from a services gateway, a request for configuration data. Also, the method includes identifying a first subset of stored configuration data that is responsive to the request. The first subset of the stored configuration data is identified using a content of the request and a state of the first subset of the stored configuration data. Additionally, the method includes sending, to the services gateway, the first subset of the stored configuration data.

Abstract: A vehicle comprises a processor programmed to: responsive to detecting a predefined event, transition a plurality of vehicle systems from a normal mode of operation to a quiet mode of operation, the transition including to adjust vehicle exhaust setting to a quiet mode, engage active noise cancellation, close vehicle windows, and adjust vehicle suspension to a predefined suspension mode.

Abstract: In accordance with an embodiment, a system and method provides a messaging service in a multitenant application server environment. Deployable resources are usable within the multitenant application server environment and groupings of resources are defined by resource group templates within a domain. One or more partitions are provided, with each partition providing an administrative and runtime subdivision of the domain that can be associated with a tenant. Java message service (JMS) resources are defined within a resource group template or a resource group, and instantiated within a partition from the one or more partitions to enable messaging for applications deployed within the partition and between the one or more partition.

Abstract: In accordance with an embodiment, a system and method provides a messaging service in a multitenant application server environment that includes a domain configuration defining an application server domain for execution of the software applications, and one or more partitions of the domain. Each partition is associated with a partition configuration and provides a subdivision of the domain. One or more resource groups enable partition-specific information for one or more deployable resources. Java message service (JMS) resources are defined within a resource group, and instantiated within a partition to enable messaging for applications deployed within the partition and between partitions. A custom store is defined within each of the resource groups for use by the JMS resources. Components of the custom store are fully partition scoped.

Abstract: A wind noise reduction apparatus for a motor vehicle includes a mirror housing, a mirror held in the mirror housing and a control module. That control module is configured to displace the mirror housing to reduce wind noise while simultaneously displacing the mirror to maintain a constant visual field.

Abstract: A wind noise throb reduction system includes a controller configured to reduce wind noise throb, an active noise cancellation subsystem responsive to the controller and a dynamic airflow control subsystem responsive to the controller. A related method of reducing wind noise throb in a passenger compartment of a motor vehicle is also provided.

Abstract: In accordance with an embodiment, a system and method provides a messaging service implementing a unit-of-order guarantee in a multitenant application server environment. The system and method of implementing unit-of-order utilizes an improved path service for routing all messages having a particular unit-of-order to the same member of the cluster. The improved path service allows for scalability of the cluster and reduced resource utilization, thereby improving the performance of a clustered computing system providing the messaging service.

Abstract: A multi-port communication device having a plurality of serial interfaces and a plurality of Transmission Control Protocol (TCP) interfaces is provided. Data is received from one or more medical devices at a serial interface of the plurality of serial interfaces and communicated to a healthcare information system via a TCP interface of the plurality of TCP interfaces. The multi-port communication device can be remotely managed by a remote device via a set of management tools. In embodiments, the set of management tools run locally on the multi-port communication device. The multi-port communication device may additionally comprise locally installed drivers that enable communication with the healthcare information system via TCP.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting object-based security features for use with messaging services in an application server environment. Credentials can be associated with a JNDI initial context or a JMS connection instead of a thread. For JNDI operations, a lookup call from the initial context can use a security subject in an initial context regardless of a security subject attached to a current thread of the lookup call. For JMS operations, the object-based security model can be enabled on a JMS connection factory, which is used to create a JMS connection associated a security subject based on credentials supplied to create the JMS connection. The JMS connection performs a plurality of JMS operations on different threads using the security subject. The object-based security model is automatically enabled for JMS connection operations once the JMS is accessed using an OBS-enabled JNDI context.

Abstract: The invention relates to a method for gateway policy enforcement. The method includes receiving configuration data from a services registry. Also, the method includes annotating, based on the configuration data, a plurality of policies with flags. In addition, the method includes binding, using the annotations of the policies, a route to at least one of the annotated policies.

Abstract: A method for monitoring application program interface integrations is provided. The method includes identifying, based on monitored transactions, a plurality of run time dependencies between at least two services. Also, the method includes creating, for each of the identified dependencies, a context of the dependency. In addition, the method includes setting a baseline state of a system utilizing the contexts.