Abstract: A composite structure comprising a body, such as an aircraft wing skin; and an opening in the body, such as a manhole. The body has steered fiber elements and terminated fiber elements. Each steered fiber element has a curved portion with a plurality of steered fibers which follow curved paths around the opening. The terminated fiber elements alternate with the steered fiber elements, and each terminated fiber element comprises a plurality of terminated fibers which terminate next to the curved portion of a respective steered fiber element.

Abstract: Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.

Abstract: A cover panel for an aircraft including: a first region, a second region for forming an overlap with a second panel, and a ramp, wherein at least a portion of the ramp is between the first and second regions, wherein the ramp includes a tapered region such that a width of the ramp tapers towards a free-edge of the first region, and wherein the free-edge is configured to form a butt-joint with the second panel.

Abstract: A method of fabricating an aircraft structural component for an aircraft includes providing a component precursor with a web and a flange extending from the web, wherein the web has a length, a height which is shorter than the length, a thickness which is shorter than the height, a first end proximal to the flange and a second end distal from the flange, applying tension to the component precursor in a direction parallel to the length of the web and with a magnitude that varies along the height of the web so as to increase the length of the web to different extents between the first end of the web and the second end of the web, sectioning the component precursor, and releasing the tension to allow shaping of the component precursor into a form required for the aircraft structural component.

Abstract: A method of fabricating an aircraft structural component for an aircraft includes providing a component precursor with a web and a flange. The web has a length, height shorter than the length, thickness shorter than the height, first end proximal to the flange and second end distal from the flange. A force is applied to the component precursor with a magnitude varying along the web height from a minimum at one of the first and second ends to a maximum at another of the first and second ends to increase length of the web to different extents. Then shaping the component precursor includes curving the component precursor into a curved shape having a first radius of curvature at the one of the first and second ends and a second radius of curvature at the another of the first and second ends, the second radius of curvature greater than the first.

Abstract: An aircraft structural component includes a flange having a non-planar side and a web having a first end extending from the non-planar side of the flange and a second end distal from the first end and from the non-planar side of the flange wherein the web has a non-planar shape that deviates from a plane normal to the non-planar side of the flange and extending in a longitudinal direction of the aircraft structural component, so that a deviation of the non-planar shape of the web from the plane increases with distance along the web in a direction from one of the first and second ends to the other of the first and second ends, and so that the deviation extends over at least 10 cm of a length of the aircraft structural component.

Abstract: A method of manufacturing an aircraft aerofoil such as a winglet. The aircraft aerofoil includes: a first cover, a second cover, an aerofoil leading edge, and an aerofoil trailing edge where the first and second cover are joined at a trailing edge interface. The first cover is formed by: a lay-up step in which a plurality of fibre plies are laid up to obtain a preform, wherein the preform has a thickness and a preform trailing edge, and the preform is laid up during the lay-up step with a ramp of decreasing thickness where the thickness of the preform decreases towards the preform trailing edge; and a curing step in which the preform is cured to form the first cover, wherein the ramp of decreasing thickness cures during the curing step to form a contact surface of the first cover.

Abstract: A cover panel for an aircraft including: a first region, a second region for forming an overlap with a second panel, and a ramp, wherein at least a portion of the ramp is between the first and second regions, wherein the ramp includes a tapered region such that a width of the ramp tapers towards a free-edge of the first region, and wherein the free-edge is configured to form a butt-joint with the second panel.

Abstract: Pharmaceutical compositions containing transferrin and, or lactoferrin for use in promoting and or inducing the generation new neural cells in a patient that has suffered a neurodegenerative event arising from at least one of a traumatic brain injury, a non-traumatic brain injury, a spinal cord injury, a peripheral nerve injury, or peripheral neuropathy. Ideally, the transferrin and/or lactoferrin have a low iron saturation.

Abstract: Pharmaceutical compositions containing transferrin or lactoferrin for use in promoting or inducing the generation new neural cells in a patient that has suffered a neurodegenerative event. The neurodegenerative event may be caused by a neurodegenerative disease such as Alzheimer's, Parkinson's, Huntington's, or amyotrophic lateral sclerosis. Ideally, the transferrin and/or lactoferrin have a low iron saturation.

Abstract: A winglet is disclosed including first and second covers, a front spar, a rear spar, a rib, and a mid spar between the front spar and the rear spar. The rib and each spar are joined to the first cover and to the second cover. The mid spar has a length and the mid spar curves along all or part of its length. The length of the mid spar extends from an inboard end of the mid spar to an outboard end of the mid spar, and the rib wraps around the inboard or outboard end of the mid spar.

Abstract: A wingtip device to attach to a wing of an aircraft includes an aerofoil portion and a connection spar arranged to be received in a connection spar receiving portion of the wing of an aircraft. The spar includes a first through hole in a first portion of the connection spar and a second through hole in a second rearward portion of the connection spar, the second portion being rearward of the first portion with respect to a direction of flight. The first and second through holes are arranged to receive a retaining pin that is to be inserted through both the first and second through holes.

Abstract: Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.

Abstract: Compositions and methods of the present invention prevent, inhibit or reduce the toxic effects of proteins and toxins secreted from microbes. A method for neutralizing microbial protein products in a subject comprises administering a composition to the subject, said composition comprising plasma-derived IgM and optionally one or more excipients in a pharmaceutical carrier, wherein the composition is administered in an amount effective to neutralize the microbial protein products.

Abstract: A composite spar is disclosed having a main body and a pair of spaced apart legs. The space between the legs permits access to the mandrel assembly within the spar in order to ease its removal. This arrangement permits a spar of any length and contour to be manufactured.

Abstract: A wingtip device to attach to a wing of an aircraft includes an aerofoil portion and a connection spar arranged to be received in a connection spar receiving portion of the wing of an aircraft. The spar includes a first through hole in a first portion of the connection spar and a second through hole in a second rearward portion of the connection spar, the second portion being rearward of the first portion with respect to a direction of flight. The first and second through holes are arranged to receive a retaining pin that is to be inserted through both the first and second through holes.

Abstract: Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.

Abstract: Compositions and methods of the present invention prevent, inhibit or reduce the toxic effects of proteins and toxins secreted from microbes. A method for neutralizing microbial protein products in a subject comprises administering a composition to the subject, said composition comprising plasma-derived IgM and optionally one or more excipients in a pharmaceutical carrier, wherein the composition is administered in an amount effective to neutralize the microbial protein products.

Abstract: Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.

Abstract: Compositions and methods of the present invention prevent, inhibit or reduce the toxic effects of proteins and toxins secreted from microbes. A method for neutralizing microbial protein products in a subject comprises administering a composition to the subject, said composition comprising plasma-derived IgM and optionally one or more excipients in a pharmaceutical carrier, wherein the composition is administered in an amount effective to neutralize the microbial protein products.