Abstract: A non-human papilloma pseudovirus or virus like particle has at least one papilloma capsid protein codon-optimized for expression in eukaryotic cells or cell lines. A pharmaceutical composition includes the non-human papilloma pseudovirus or virus like particle, and a diagnostic agent, an imaging agent, and a therapeutic agent. A non-human papilloma pseudovirus or virus like particle can be used as a medicament. A method for producing a non-human papilloma pseudovirus or virus like particle involves codon-optimizing of capsid proteins of non-human papillomaviruses for expression in eukaryotic cells, synthesizing of the sequences and cloning of the synthesized sequences into expression vectors, and producing non-human papilloma pseudovirus or virus like particles. ?-carrageenan can be used as transduction enhancer for non-human papilloma pseudovirus or virus like particles in vitro.

Abstract: A floor scale (10) intended for use in an environment requiring hygienic cleaning has a load platform (12) that is supported by a frame (18). A pair of foot assemblies 26, positioned along the sides of the frame, anchor the frame to the floor and provide a base from which the frame and load platform may be pivoted about an axis (A) between an operative position in which an upper surface (14) of the load platform is substantially parallel to the floor and a non-operative position in which the upper surface is angled obliquely relative to the floor. In the non-operative position, a footprint (F) of the floor scale is accessible for cleaning, Structural members of the frame and foot assemblies are substantially devoid of horizontal concave surfaces in which liquids could pool. Locking means is provided for the operative position and at least one non-operative position.

Abstract: The invention is directed to a multilayered collagen structure having at least two layers having different densities. The invention is further directed to a method for preparing such multilayered structure, wherein the method comprises compressing fibrillated collagen in the presence of at least one distancing element.

Abstract: Gearbox (1) having a tooth carrier (40) for receiving teeth (7) of a gear ring that are disposed about a rotation axis (5) of the gearbox, wherein the teeth (7) are disposed in the tooth carrier (11) so as to be displaceable and guided in the radial direction, a cam disk (20) which is rotatable about the rotation axis (5) and for driving the teeth (7) in the radial direction has a cam curvature that is variable over the circumference, wherein bearing segments (24) which are mounted so as to slide on the cam disk (20) are disposed between the teeth (7) and the cam disk (20), and wherein the bearing segments (24) have a contact region which has a concave curvature and is disposed so as to be centric on a running surface that faces the cam disk (20), wherein the concave curvature is larger than the smallest cam curvature of the cam disk, and smaller than the largest cam curvature of the cam disk.

Abstract: The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).

Abstract: Coaxial gear mechanism (1), having a toothing (5) oriented axially with respect to an axis of rotation (3) of the coaxial gear mechanism (1), a tooth carrier (7) with axially oriented guides (9), tooth pins (11) which each have a body (41), which is mounted in an axially displaceable manner in a guide (9) of the tooth carrier (7), and a head region (51), wherein the head region (51) has at least one tooth (53) for engagement with the toothing (5), and wherein the head region (51) is configured to be wider than the body (41).

Abstract: This invention provides a non-surgical method for treating periodontitis comprising administering an article into a periodontal pocket, where the article comprises crosslinked collagen and hydroxyapatite. This invention also provides articles to be used within these methods.

Abstract: The present invention relates to cyclized peptides based on amino acids 1-14 of amyloid-beta. The cyclic peptides are useful for inducing an immune response and as vaccines for the treatment of neurodegenerative diseases such as Alzheimer's disease.

Abstract: Coaxial gear mechanism (1), with a toothing (5) oriented axially relative to a rotational axis (3) of the coaxial gear mechanism (1), a tooth carrier (7) with axially oriented guides (9), teeth (11) which are received in the guides (9) for engagement with the toothing (5), wherein the teeth are oriented with their respective longitudinal axes (13) axially in the guides (9) and are mounted so as to be axially movable in the guides (9), and a cam disk (15) which is rotatable about the rotational axis (3) for axially driving the teeth (11), wherein a plurality of bearing segments (17) is arranged between the cam disk (15) and the teeth (11) for supporting the teeth (11).

Abstract: Coaxial gear mechanism, with a toothing system which is oriented axially with regard to a rotational axis of the coaxial gear mechanism; a tooth carrier with axially oriented guides; teeth which are received in the guides for engagement with the toothing system, the teeth being oriented with their respective longitudinal axes axially in the guides and being mounted in the guides such that they can be displaced axially; a cam disc which can be rotated about the rotational axis for the axial drive of the teeth; and a housing, in which a setting element for mounting the cam disc is provided, at least one bearing with rolling bodies being arranged between the setting element and the cam disc.

Abstract: Bolt type angular gear mechanism (1) for transmitting a rotational movement from a first shaft to a second shaft which is orientated at an angle with respect to the first shaft, comprising a plurality of angular bolts (31, 32) each having two members, a first bolt carrier (21) which can be rotated about a first axis and which has receiving members (4) for the first members of the angular bolts (31, 32) in each case, a second bolt carrier (22) which can be rotated about a second axis and which has receiving members (4) for the second members of the angular bolts (31, 32) in each case so that the bolt carriers (21, 22) are connected by means of the angular bolts (31, 32), wherein the axes define an angle, and wherein the members of the angular bolts (31, 32) are each constructed in a cylindrical manner as far as a plane of the angle bisector between the axes.

Abstract: The invention is directed to an implantable structure comprising at least one biocompatible backbone scaffold and at least one biocompatible and biodegradable collagen membrane deposited thereon, including methods of its preparation and uses thereof in dental or orthopedic bone regeneration, dura repairs, hernia repairs and similar procedures requiring structural implants.

Abstract: The present invention provides compositions comprising collagen, including kits thereof and methods for their use.

Abstract: Coaxial gear mechanism (1), having a toothing (5) oriented axially with respect to an axis of rotation (3) of the coaxial gear mechanism (1), a tooth carrier (7) with axially oriented guides (9), tooth pins (11) which each have a body (41), which is mounted in an axially displaceable manner in a guide (9) of the tooth carrier (7), and a head region (51), wherein the head region (51) has at least one tooth (53) for engagement with the toothing (5), and wherein the head region (51) is configured to be wider than the body (41).

Abstract: Coaxial gear mechanism, with a toothing system which is oriented axially with regard to a rotational axis of the coaxial gear mechanism; a tooth carrier with axially oriented guides; teeth which are received in the guides for engagement with the toothing system, the teeth being oriented with their respective longitudinal axes axially in the guides and being mounted in the guides such that they can be displaced axially; a cam disc which can be rotated about the rotational axis for the axial drive of the teeth; and a housing, in which a setting element for mounting the cam disc is provided, at least one bearing with rolling bodies being arranged between the setting element and the cam disc.

Abstract: The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).

Abstract: Coaxial gear mechanism (1), with a toothing (5) oriented axially relative to a rotational axis (3) of the coaxial gear mechanism (1), a tooth carrier (7) with axially oriented guides (9), teeth (11) which are received in the guides (9) for engagement with the toothing (5), wherein the teeth are oriented with their respective longitudinal axes (13) axially in the guides (9) and are mounted so as to be axially movable in the guides (9), and a cam disk (15) which is rotatable about the rotational axis (3) for axially driving the teeth (11), wherein a plurality of bearing segments (17) is arranged between the cam disk (15) and the teeth (11) for supporting the teeth (11).

Abstract: In order to prevent stamps or indicia from being forged and in order to bill a logistics service between different postal service providers correctly to the user, a computer-implemented method for franking postal articles is implemented. The article's progress is recorded by readers and, together with the accompanying franking identification, is stored in blocks of a blockchain as a transaction. In doing so, the assignment of the readers to a postal service provider is recorded. The logistics service provided is billed correctly to the user by analyzing the transactions stored in the blockchain that are to be allocated to at least one postal service provider.

Abstract: This invention is directed to a shaped block, a dental implant abutment comprising an implant, an abutment and a shaped block, wherein the shaped block comprises a dried collagen matrix; and a method of preparation thereof.

Abstract: Systems, methods, and computer program products for trace management in a distributed computing environment are described. A trace manager receives a request to analyze a trace of a series of calls between applications serving requests in a microservice architecture. The trace manager determines metrics including, for example, latency information and start time for the series of calls. The trace manager presents the metrics in association with log entries correlated to the series of calls. A call stack, or one or more latency indicators, provides a user interface of selecting one or more calls. A user selection of a particular call in the call stack or a latency indicator causes one or more corresponding log entries to be emphasized or filtered. The call stack and the one or more latency indicators can have various display configurations.