Abstract: The present invention provides compositions and methods useful in the diagnosis and treatment of a variety of cognitive impairments including vascular cognitive impairment and dementia, and Alzheimer's Disease. In one particular embodiment, the level of the neurofilament light protein and/or phosphorylated tau (e.g., p-tau181) is used to diagnose a cognitive impairment or monitor the efficacy of a therapy.

Abstract: Certain aspects of the present disclosure provide techniques for semantically contextualizing structured and unstructured data, extracting and making sense of domain knowledge, and performing semantic-driven optimization to provide generic, scalable, autonomous and real-time performance management within a built environment domain.

Abstract: A method for measuring a metal surface treatment of a metal component includes creating a solid model of the metal component, identifying surface locations on the metal component at which a set of structural properties is specified by design, and identifying a simulated location on the solid model corresponding to the identified surface location on the metal component. The method includes preparing a simulation fixture plan for fabricating a simulation fixture having an element for supporting a test strip holder thereon at the identified simulated location, and then fabricating the simulation fixture. A test strip holder is positioned at the identified simulated location on the simulation fixture, and a test strip is positioned in the test strip holder. The simulation fixture is subjected to the metal surface treatment wherein the simulation fixture has the test strip holder positioned thereon and the test strip holder has the test strip positioned thereon.

Abstract: A protected test strip holder according to the present invention includes a test strip holder onto which a test strip, such as for example an Almen strip, may be mounted using fasteners provided on the test strip holder. A protective covering is form-fitted to the test strip holder and, optionally, to the test strip holder having a test strip mounted thereon. The present invention also comprises a method for protecting and storing a test strip holder that includes providing a test strip holder, forming or molding a protective covering form-fitting to the test strip holder, and placing the protective covering over the test strip holder. The test strip holder may have a test strip mounted thereon prior to molding the form-fitting protective covering.