Patents by Inventor Thomas BEKEL

Thomas BEKEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11198895
    Abstract: Fermentative production of L-lysine using an L-lysine excreting bacterium of the species Corynebacterium glutamicum having a completely or partly deleted whiB4 gene is provided.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: December 14, 2021
    Assignee: Evonik Operations GmbH
    Inventors: Georg Thierbach, Frank Schneider, Kornelia Voß, Thomas Bekel
  • Publication number: 20210355515
    Abstract: Fermentative production of L-lysine using an L-lysine excreting bacterium of the species Corynebacterium glutamicum having a completely or partly deleted whiB4 gene is provided.
    Type: Application
    Filed: November 27, 2019
    Publication date: November 18, 2021
    Applicant: Evonik Operations GmbH
    Inventors: Georg Thierbach, Frank Schneider, Kornelia Voß, Thomas Bekel
  • Patent number: 10829746
    Abstract: A bacterium of the species Corynebacterium glutamicum has the ability to excrete L-lysine, and contains in its chromosome a polynucleotide encoding a mutated polypeptide having the assumed function of an acyltransferase, hydrolase, alpha/beta hydrolase or of a pimeloyl-ACP methyl ester esterase. Also, a method is used for producing L-lysine using such bacterium.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: November 10, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Frank Schneider, Georg Thierbach, Kornelia Voß, Thomas Bekel
  • Publication number: 20200231946
    Abstract: A bacterium of the species Corynebacterium glutamicum has the ability to excrete L-lysine, and contains in its chromosome a polynucleotide encoding a mutated polypeptide having the assumed function of an acyltransferase, hydrolase, alpha/beta hydrolase or of a pimeloyl-ACP methyl ester esterase. Also, a method is used for producing L-lysine using such bacterium.
    Type: Application
    Filed: December 18, 2019
    Publication date: July 23, 2020
    Applicant: Evonik Operations GmbH
    Inventors: Frank Schneider, Georg Thierbach, Kornelia Voss, Thomas Bekel
  • Patent number: 10717999
    Abstract: A method is useful for the fermentative production of L-lysine using a C. glutamicum strain having a mutated Kup transporter.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: July 21, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Thomas Bekel, Kornelia Voss, Georg Thierbach, Frank Schneider
  • Patent number: 10689677
    Abstract: A method is used for the fermentative production of L-lysine using bacteria of the species Corynebacterium glutamicum, having the ability to excrete L-lysine and containing in their chromosome a mutated NCgl2816 polynucleotide. Further, the method is used for cultivating the bacteria in a suitable medium under suitable conditions, and accumulating said L-lysine in the suitable medium to form an L-lysine containing fermentation broth.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: June 23, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Frank Schneider, Georg Thierbach, Thomas Bekel, Kornelia Voβ
  • Publication number: 20200190546
    Abstract: A method is useful for the fermentative production of L-lysine using a C. glutamicum strain having a mutated Kup transporter.
    Type: Application
    Filed: December 3, 2019
    Publication date: June 18, 2020
    Applicant: Evonik Operations GmbH
    Inventors: Thomas Bekel, Kornelia Voss, Georg Thierbach, Frank Schneider
  • Patent number: 10683511
    Abstract: The present invention provides a bacterium of the genus Corynebacterium, in particular of the species Corynebacterium glutamicum, having the ability to excrete an L-amino acid selected from proteinogenic L-amino acids and L-omithine and new measures for the fermentative production of proteinogenic L-amino acids and L-ornithine by such bacteria.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: June 16, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Georg Thierbach, Thomas Bekel, Kornelia Voss
  • Publication number: 20200095622
    Abstract: A method is used for the fermentative production of L-lysine using bacteria of the species Corynebacterium glutamicum, having the ability to excrete L-lysine and containing in their chromosome a mutated NCgl2816 polynucleotide. Further, the method is used for cultivating the bacteria in a suitable medium under suitable conditions, and accumulating said L-lysine in the suitable medium to form an L-lysine containing fermentation broth.
    Type: Application
    Filed: September 18, 2019
    Publication date: March 26, 2020
    Applicant: Evonik Operations GmbH
    Inventors: Frank SCHNEIDER, Georg Thierbach, Thomas Bekel, Kornelia Voss
  • Publication number: 20200032306
    Abstract: A novel method is used for the fermentative production of L-lysine using bacteria of the species Corynebacterium glutamicum, having the ability to excrete L-lysine, containing in their chromosome a variant of a polynucleotide encoding a polypeptide having hydrolase activity. The bacteria are cultivated in a suitable medium under suitable conditions, and then L-lysine is accumulated in the medium to form an L-lysine containing fermentation broth.
    Type: Application
    Filed: July 19, 2019
    Publication date: January 30, 2020
    Applicant: Evonik Degussa GmbH
    Inventors: Frank SCHNEIDER, Georg Thierbach, Kornelia Voss, Thomas Bekel
  • Publication number: 20200017893
    Abstract: A novel method is for the fermentative production of L-lysine using bacteria of the species Corynebacterium glulamicum. The bacteria have the ability to excrete L-lysine and contain in their chromosome a polynucleotide, which encodes a polypeptide having the activity of a transcriptional factor. An amino acid at a particular position of the amino acid sequence of the polypeptide has been substituted by a different proteinogenic amino acid.
    Type: Application
    Filed: July 10, 2019
    Publication date: January 16, 2020
    Applicant: Evonik Degussa GmbH
    Inventors: Thomas BEKEL, Frank Schneider, Georg Thierbach, Kornelia Voß
  • Publication number: 20190185890
    Abstract: The present invention makes available novel L-lysine excreting bacteria of the species Corynebacterium glutamicum, having the ability to excrete L-lysine, containing in their chromosome a polynucleotide encoding a polypeptide having the activity of a malate:quinone reductase wherein the amino acid at position 228 of the amino acid sequence of the polypeptide contains any proteinogenic amino acid different from valine and a method for producing L-lysine using such bacteria.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 20, 2019
    Inventors: Kornelia VOSS, Georg THIERBACH, Thomas BEKEL
  • Publication number: 20190106721
    Abstract: A method for the fermentative production of an L-amino acid, selected from L-lysine, L-threonine and L-isoleucine, includes cultivating a bacterium of the genus Corynebacterium having the ability to excrete said L-amino acid in a suitable medium under suitable conditions. The method also includes accumulating said L-amino acid in the medium to form an L-amino acid containing fermentation broth. Said bacterium comprises a polynucleotide coding for a polypeptide conferring a resistance to lincosamides which has been modified by deleting or replacing at least parts of said polynucleotide and at least one copy of a gene coding for a feedback resistant aspartokinase.
    Type: Application
    Filed: October 2, 2018
    Publication date: April 11, 2019
    Applicant: Evonik Degussa GmbH
    Inventors: Thomas BEKEL, Georg Thierbach, Kornelia Voß
  • Publication number: 20190085340
    Abstract: The present invention provides a bacterium of the genus Corynebacterium, in particular of the species Corynebacterium glutamicum, having the ability to excrete an L-amino acid selected from proteinogenic L-amino acids and L-omithine and new measures for the fermentative production of proteinogenic L-amino acids and L-ornithine by such bacteria.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 21, 2019
    Inventors: Georg Thierbach, Thomas Bekel, Kornelia Voss
  • Publication number: 20180312905
    Abstract: The current invention relates to a microvesicle based method of detecting avian necrotic enteritis as well as to new markers which have been identified as suitable for detection of avian necrotic enteritis and/or avian infection by Clostridium perfringens.
    Type: Application
    Filed: February 19, 2016
    Publication date: November 1, 2018
    Applicant: Evonik Degussa GmbH
    Inventors: Emeka-Ignatius IGWE, Holger WALLMEIER, Stefan PELZER, Monika FLÜGEL, Thomas BEKEL