Abstract: Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.

Abstract: A drive mechanism for installing thread protectors on threaded pipe ends having a servo motor, a housing, a shaft assembly, and a gripper with a plurality of jaws. The shaft assembly has a hollow shaft, rotationally mounted within the housing, and a solid shaft slidably mounted within the hollow shaft. The hollow shaft and solid shaft are coaxial and rotationally coupled. The gripper is mounted on the end of the solid shaft, outside of the housing, and is biased away from the housing. A sensor monitors the relative axial motion between the solid shaft and the hollow shaft.

Abstract: In one embodiment, a method includes receiving, at each of at least four receivers of a stylus, a signal from an electrode line oriented along a first axis of a touch-sensing device and determining, by a processor of the stylus, a signal strength of the signal at each of the at least four receivers of the stylus. The received signal has a different signal strength at each of the at least four receivers. The method includes determining, by the processor of the stylus, a tilt direction of the stylus based on the determined signal strength at a plurality of the at least four receivers, and providing, by a transmitter of the stylus, a response signal to the touch-sensing device. The tilt direction includes a direction of the stylus along a second axis of the touch-sensing device and the second axis is oriented in a different direction than the first axis.

Abstract: A device (10,110) for lifting a structure (59) having an aperture (62) therein, the device (10,110) including a body (12, 112) adapted to locate the device (10,110) relative to the aperture (62) of the structure (59) and a pin (18, 118) moveably receivable by a bore (16, 116) of the body (12, 112), the pin (18, 118) including a foot (22, 122) which is arranged to pass through the aperture (62) of the structure (59) in a first orientation and be rotated to a second orientation such that the foot (22, 122) is engagable with the aperture (62) of the structure (59).

Abstract: In one embodiment, a method includes receiving, at each of at least four receivers of a stylus, a signal from an electrode line oriented along a first axis of a touch-sensing device and determining, by a processor of the stylus, a signal strength of the signal at each of the at least four receivers of the stylus. The received signal has a different signal strength at each of the at least four receivers. The method includes determining, by the processor of the stylus, a tilt direction of the stylus based on the determined signal strength at a plurality of the at least four receivers, and providing, by a transmitter of the stylus, a response signal to the touch-sensing device. The tilt direction includes a direction of the stylus along a second axis of the touch-sensing device and the second axis is oriented in a different direction than the first axis.

Abstract: A detector for determining the location of a pulsed laser spot reflected from a scene, which comprises a CCD sensor for imaging the scene comprising an array of pixels arranged in rows (R1, R2, R3) and columns (C1, C2, C3), a serial read-out register arrangement (not shown), and charge transfer electrodes (Ø1H, Ø1V, Ø2) capable of transferring signal charge in at least two adjacent pixels to read-out register arrangement locations representative of the row location of at least one of the adjacent pixels and the column location of at least one other of the adjacent pixels. The charge transfer electrodes are two phase, but three or more phase arrangements are also possible.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.

Abstract: The present invention relates to a method of modifying a surface characteristic (e.g., wear resistance and/or corrosion resistance) of a cobalt-chromium based alloy article. The method comprises plasma treating the article at a temperature in the range of from 300° C. to 700° C. and at a pressure of from 100 Pa to 1500 Pa for 1 hour to 50 hours in an atmosphere comprising at least one carbon-containing gas, whereby to introduce carbon into a surface region of said article. The present invention also resides in a surface-hardened cobalt-chromium based article producible by the method of the invention. The article is characterised by having a surface region comprising a supersaturated solid solution of carbon in cobalt or a surface region comprising a supersaturated solid solution of carbon in cobalt and chromium carbides. Surface hardened articles producible by the method of the invention include medical implants and engineering components.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a CETP mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or HDL activity and reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.

Abstract: A CCD sensor has a shutter to prevent frame shift smear during transfer of an image from the image region to a store region. The CCD sensor has an extended dynamic range, because each integration is in two parts, the second part of which has a different sensitivity than the first part. In order to avoid an asymmetry in the uncovering and covering of the image region, a two-bladed shutter is used.

Abstract: A CCD such as a frame transfer CCD has an extended dynamic range. The image built up in the image region 1 in each integration period is transferred to the store region 2 in each frame transfer period, for example, at a TV signal rate. The dynamic range is increased by dividing the integration period into two parts, and clipping the signal in the first part, but not in the second. The signal is clipped by pulsing the clock electrodes of the image region so as to combine the charges from adjacent wells together, overspill being drained into the anti-blooming structure, consequently reducing well capacity.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a TTC39 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL and/or decreasing PCSK9 in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate cardiovascular disease, or a symptom thereof.

Abstract: A system for time resolved spectroscopy comprises a CCD device arranged to receive a time varying spectrum. Time resolved spectroscopy is the analysis of a spectrum that varies with time due to any cause. The variation with time of the spectrum may be due, for example, to (i) changes of the spectrum from a given sample space with time (such as due to emission decay); and (ii) changes in the spectrum as successive portions of a sample space are sampled (such as laser scanning microscopy). The CCD device comprises an array of photosites arranged to detect the time varying spectrum and to produce signal charge representative of the spectrum, and one or more CCD multiplication registers arranged to receive the signal charge and to provide charge multiplication. An enhancement of speed and sensitivity is given by a storage area which receives the signal charge in parallel from the array of photosites to provide the charge in serial to the one or more multiplication registers.

Abstract: A CCD such as a frame transfer CCD has an extended dynamic range. The image built up in the image region 1 in each integration period is transferred to the store region 2 in each frame transfer period, for example, at a TV signal rate. The dynamic range is increased by dividing the integration period into two parts, and clipping the signal in the first part, but not in the second. The signal is clipped by pulsing the clock electrodes of the image region so as to combine the charges from adjacent wells together, overspill being drained into the anti-blooming structure, consequently reducing well capacity.