Abstract: A touchscreen cover assembly embodiment is configured to create a sterile interface between a touchscreen and a user and includes a sterile frame and a sterile cover member. The sterile frame includes a forward frame surface and a rearward frame surface opposite the forward frame surface. The sterile frame defines an interior opening, and the sterile frame is configured to be secured to the touchscreen such that the rearward frame surface faces the touchscreen and the interior opening is aligned with a user interface of the touchscreen. The sterile cover member includes a forward cover portion and a rearward cover portion. The sterile cover member is configured to be secured to the touchscreen by the sterile frame such that the forward cover portion is positioned between the interior opening and the user interface of the touchscreen and the rearward cover portion is positioned over a housing of the touchscreen.