Patents by Inventor Thomas Berthelot

Thomas Berthelot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11014121
    Abstract: The invention relates to a method for functionalising a surface of a solid substrate with at least one acrylic acid polymer layer, said method including the steps of: i) placing the surface in contact with a solution having of at least one acrylic acid homopolymer, a solvent and, optionally, metal salts; ii) removing the solvent from the solution in contact with the surface; and iii) binding the polymer to the surface by thermal treatment.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: May 25, 2021
    Assignee: Commissariat A L'Energie Atomique Et Aux Energies Alternatives
    Inventors: Pascal Viel, Thomas Berthelot, Xavier Lefevre, Jérôme Polesel Maris
  • Patent number: 11009573
    Abstract: A liquid-state nuclear-magnetic-resonance measurement cell includes a reservoir for a liquid medium; a fluidic circuit connected to the reservoir and comprising a measurement chamber; a gas injector opening into the fluidic circuit, at a distance from the measurement chamber; and a coil encircling the measurement chamber; wherein it also comprises at least one capacitive element forming, with the coil, an electromagnetic resonator; and in that it has a shape allowing its introduction into a nuclear-magnetic-resonance probe in replacement of an assembly formed by a nuclear-magnetic-resonance tube and a spinner bearing the tube, the coil encircling the measurement chamber being then positioned so as to couple by induction to at least one radiofrequency coil of the probe. Nuclear-magnetic-resonance measurement system comprising such a measurement cell. Magnetic-resonance measurement method using such a cell is also provided.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: May 18, 2021
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Guillaume Carret, Thomas Berthelot, Patrick Berthault
  • Publication number: 20210069971
    Abstract: A deposition system including: a container arranged to contain material to be deposited and including an inlet and an outlet, a pneumatic system arranged to inject, through the entrance, gas in the container, so this gas exerts pressure on the material to be deposited. The deposition system including a controller of the pneumatic system arranged to control at least one injection, through the inlet, of gas at an adjusting pressure, so that a convex meniscus of material to be deposited protrudes from the outlet of the container, then at least one gas' injection, through the inlet, respectively at least a deposition pressure greater than the adjusting pressure, so that the material to be deposited flows out of the container by its outlet.
    Type: Application
    Filed: May 16, 2019
    Publication date: March 11, 2021
    Inventors: Thomas BERTHELOT, Didier ROUSSEAU
  • Publication number: 20200033427
    Abstract: A liquid-state nuclear-magnetic-resonance measurement cell includes a reservoir for a liquid medium; a fluidic circuit connected to the reservoir and comprising a measurement chamber; a gas injector opening into the fluidic circuit, at a distance from the measurement chamber; and a coil encircling the measurement chamber; wherein it also comprises at least one capacitive element forming, with the coil, an electromagnetic resonator; and in that it has a shape allowing its introduction into a nuclear-magnetic-resonance probe in replacement of an assembly formed by a nuclear-magnetic-resonance tube and a spinner bearing the tube, the coil encircling the measurement chamber being then positioned so as to couple by induction to at least one radiofrequency coil of the probe. Nuclear-magnetic-resonance measurement system comprising such a measurement cell. Magnetic-resonance measurement method using such a cell is also provided.
    Type: Application
    Filed: March 8, 2018
    Publication date: January 30, 2020
    Inventors: Guillaume CARRET, Thomas BERTHELOT, Patrick BERTHAULT
  • Patent number: 10428435
    Abstract: The present invention relates to a method for modifying the surface of a substrate made of electrically conductive metal oxide and notably made of ITO, comprising the following steps consisting in: (i) bringing into contact said surface with a solution containing copper ions (Cu2+) and ammonia then washing and optionally drying the surface thus obtained; and (ii) bringing into contact the surface obtained following step (i) with a solution containing sodium tetraborohydride then washing and optionally drying the surface of said conductive metal oxide substrate. The present invention relates to the use of such a method within the scope of the metallization by copper of a conductive metal oxide substrate as well as the surfaces of a modified and metallized conductive metal oxide substrate thus obtained.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: October 1, 2019
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Yoan Bourlier, Thomas Berthelot
  • Patent number: 10365236
    Abstract: There is provided a Nuclear Magnetic Resonance (NMR) measurement cell for use with a solution enabling the introduction of a gas into said solution. The measurement cell includes at least a detection volume designed to be installed in a static magnetic field of an NMR spectrometer, and includes in said detection volume, a gas introduction zone, a measurement chamber for the solution at a distance from the gas introduction zone and a network of conduits for the solution formed to set up fluid communication between the gas introduction zone and the measurement chamber. The gas introduction zone includes at least one gas inlet in the network of conduits, to generate bubbles in the gas introduction zone only. There is also provided a method of manufacturing such a measurement cell and a measurement assembly including such a measurement cell.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: July 30, 2019
    Assignee: Comissariat a l'energie atomique et aux energies alternatives
    Inventors: Alexandre Causier, Patrick Berthault, Thomas Berthelot, Guillaume Carret
  • Patent number: 10272157
    Abstract: A process for preparing a porous solid with an outer surface modified by at least one polymer; the polymer being simultaneously synthetized in solution and grafted on the outer surface of the solid, includes contacting: a porous solid; and a polymer-precursor solution comprising an adhesion primer, and at least one polymerizable monomer; under conditions enabling the formation of radical entities.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 30, 2019
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (CEA), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE VERSAILLES SAINT-QUENTIN-EN-YVELINES, UNIVERSITE PARIS-SUD 11
    Inventors: Thomas Berthelot, Elena Bellido Vera, Ruxandra Gref, Patricia Horcajada Cortes, Christian Serre, Patrick Couvreur
  • Patent number: 9890235
    Abstract: A method is provided for preparing an organic film on the surface of a solid support including the steps of (a) applying, to the surface, by transfer or by spraying, a solution containing at least one cleavable aryl salt; and (b) subjecting the solution to a UV or visible irradiation, such that irradiation radical entities are formed from the cleavable aryl salt and an organic film is grafted. Further provided is a kit of elements for the implementation of such a method.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: February 13, 2018
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Thomas Berthelot, Pascal Viel, Alexandre Garcia, Bruno Jousselme, Cecile Baudin
  • Patent number: 9835576
    Abstract: A method of manufacturing a biosensor having a microbeam linked to a support, at least one electrode a biological molecule A grafted onto the microbeam in a different zone from the zone where the electrode is embedded, and a mechanoelectrical transducer for converting variations of the mechanical properties of the microbeam into an electrical signal, when the biological molecule A is placed in contact with a biological molecule B to be detected and/or quantified. The method includes: formation of an electrode on fluoropolymer material sheet, passivation of the electrode(s), creation of the form of the biosensor in the sheet of polymer material and separation of this form from the sheet, functionalization either of a prefunctionalized zone or of a zone of the microbeam, this zone being different from the zone wherein the electrode is embedded, and grafting of a biological molecule A onto the functionalized zone.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: December 5, 2017
    Assignee: Commissariat A L'Energie Atomique Et Aux Energies Alternatives
    Inventors: Jérôme Polesel Maris, Thomas Berthelot
  • Publication number: 20170298525
    Abstract: The present invention relates to a method for modifying the surface of a substrate made of electrically conductive metal oxide and notably made of ITO, comprising the following steps consisting in: (i) bringing into contact said surface with a solution containing copper ions (Cu2+) and ammonia then washing and optionally drying the surface thus obtained; and (ii) bringing into contact the surface obtained following step (i) with a solution containing sodium tetraborohydride then washing and optionally drying the surface of said conductive metal oxide substrate. The present invention relates to the use of such a method within the scope of the metallisation by copper of a conductive metal oxide substrate as well as the surfaces of a modified and metallised conductive metal oxide substrate thus obtained.
    Type: Application
    Filed: April 14, 2017
    Publication date: October 19, 2017
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Yoan BOURLIER, Thomas Berthelot
  • Patent number: 9725602
    Abstract: This invention relates to a method for preparing an organic film at the surface of a solid support, with a step of contacting said surface with a liquid solution including (i) at least one solvent, (ii) at least one adhesion primer, under non-electrochemical conditions, and allowing the formation of radical entities based on the adhesion primer. The liquid solution can also include (iii) at least one monomer different from the adhesion primer and radically polymerizable. This invention also relates to a non-electrically-conductive solid support on which an organic film according to said method is grafted, and a kit for preparing an essentially polymeric organic film at the surface of a solid support.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: August 8, 2017
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Vincent Mevellec, Sebastien Roussel, Serge Palacin, Guy Deniau, Thomas Berthelot, Cecile Baudin, Adhitya Trenggono
  • Publication number: 20170113249
    Abstract: The invention relates to a method for functionalising a surface of a solid substrate with at least one acrylic acid polymer layer, said method including the steps of: i) placing the surface in contact with a solution having of at least one acrylic acid homopolymer, a solvent and, optionally, metal salts; ii) removing the solvent from the solution in contact with the surface; and iii) binding the polymer to the surface by thermal treatment.
    Type: Application
    Filed: April 3, 2015
    Publication date: April 27, 2017
    Inventors: Pascal Viel, Thomas Berthelot, Xavier Lefevre, Jérôme Polesel Maris
  • Publication number: 20170102380
    Abstract: The immobilization of biomolecules on a non-functionalized carrier by irradiating the biomolecule-impregnated carrier with a light of a wavelength of at least 340 nm.
    Type: Application
    Filed: March 5, 2015
    Publication date: April 13, 2017
    Inventors: Julie CREDOU, Thomas BERTHELOT, Rita FADDOUL
  • Patent number: 9453284
    Abstract: The present invention relates to a process for chemically modifying, within its thickness, a polymer matrix chosen from matrices made of fluoropolymers and matrices made of aliphatic polymers, said process comprising at least one step consisting in irradiating said matrix with UV light having a wavelength of less than 300 nm in order to generate, within the thickness of said matrix, zones that have short polymer chains, formed by scission of the existing chains during the passage of the UV radiation and that have free radicals denoted hereinbelow as “activated zones”. The present invention also relates to the polymer matrix capable of being chemically modified by such a process.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: September 27, 2016
    Assignee: Commissariat a L'Energie Atomique et aux Energies Alternatives
    Inventors: Thomas Berthelot, Cécile Baudin
  • Publication number: 20160178544
    Abstract: There is provided a Nuclear Magnetic Resonance (NMR) measurement cell for use with a solution enabling the introduction of a gas into said solution. he measurement cell includes at least a detection volume designed to be installed in a static magnetic field of an NMR spectrometer, and includes in said detection volume, a gas introduction zone, a measurement chamber for the solution at a distance from the gas introduction zone and a network of conduits for the solution formed to set up fluid communication between the gas introduction zone and the measurement chamber. The gas introduction zone includes at least one gas inlet in the network of conduits, to generate bubbles in the gas introduction zone only. There is also provided a method of manufacturing such a measurement cell and a measurement assembly including such a measurement cell.
    Type: Application
    Filed: December 16, 2015
    Publication date: June 23, 2016
    Applicant: Commissariat A L'Energie Atomique et aux Energies Alternatives
    Inventors: Alexandre CAUSIER, Patrick BERTHAULT, Thomas BERTHELOT, Guillaume CARRET
  • Publication number: 20160101192
    Abstract: A process for preparing a porous solid with an outer surface modified by at least one polymer; the polymer being simultaneously synthetized in solution and grafted on the outer surface of the solid, includes contacting: a porous solid; and a polymer-precursor solution comprising an adhesion primer, and at least one polymerizable monomer; under conditions enabling the formation of radical entities.
    Type: Application
    Filed: October 8, 2015
    Publication date: April 14, 2016
    Inventors: Thomas BERTHELOT, Elena BELLIDO VERA, Ruxandra GREF, Patricia HORCAJADA CORTES, Christian SERRE, Patrick COUVREUR
  • Patent number: 9139862
    Abstract: The invention pertains to a cyclic peptide comprising the following sequence: -S1-X1-S2-X2- wherein S1 is a first target peptide sequence of a protease enzyme E1, S2 is a second target peptide sequence of a protease enzyme E2, S1 and S2 possibly being the same or different, said first peptide sequence S1 and said second peptide sequence S2 comprising 4 to 14 amino acids, E1 and E2 possibly corresponding to the same protease enzyme or to two different protease enzymes, X1 is a probe carrying a fluorescent donor group and X2 is a probe carrying a fluorescent or non-fluorescent acceptor group. Application of these peptides to determination of the activity of protease enzymes.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: September 22, 2015
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE VICTOR SEGALEN-BORDEAUX 2
    Inventors: Thomas Berthelot, Gérard Deleris
  • Patent number: 9085715
    Abstract: The present invention relates to a process for assembling at least one zone of a first surface with at least one zone of a second surface or with a molecule of interest, comprising a step that consists in placing the said zone of the said first surface in contact with the said zone of the said second surface or with the said molecule of interest, the said zone of the said first surface bearing at least one radical and/or ionic species. The present invention also relates to a solid support whose surface bears at least one zone with at least one radical and/or ionic species, with at least one adhesion primer, or with at least one adhesion primer precursor, and to its various uses.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: July 21, 2015
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Thomas Berthelot, Guy Deniau, Vincent Huc, Xuan Tuan Le, Fabien Nekelson, Sébastien Roussel, Pascal Viel
  • Patent number: 8959661
    Abstract: An atomic force microscope probe comprising a piezo-electric resonator provided with two electrodes and coated with an insulating layer and a tip attached on the coated resonator and functionalized with at least one group or molecule of interest is disclosed. The disclosed technology also relates to preparation method and to different uses thereof.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: February 17, 2015
    Assignee: Commissariat à l'Énergie Atomique et aux Énergies Alternatives
    Inventors: Jérôme Polesel-Maris, Thomas Berthelot, Pascal Viel
  • Publication number: 20140349279
    Abstract: The present invention relates to a three dimensional (or 3D) microfluidic system comprising a plurality of layers stacked upon each other, characterised in that at least one of said layers consists of a 1st and at least one 2nd parts, distinct from each other, with the 2nd part being porous and wettable by a solution of interest, nesting into a recess of the 1st part being non-porous and/or non-wettable by said solution of interest, wherein said system can possibly have a built-in reservoir; a method for manufacturing the same and different uses thereof.
    Type: Application
    Filed: December 14, 2012
    Publication date: November 27, 2014
    Inventors: Thomas Berthelot, Hervé Volland