Abstract: The invention is directed to a computer environment in which a management system for a transportation carrier, e.g., an airline carrier, generates a list of routings based on preference data for a customer. The preference data includes data that may be used to select a particular routing, e.g., ticket class, seat assignment, meal service, airline, type of aircraft, connection points, connection times, fare, and an extended travel window. The preference data may be entered via a network user interface and stored in a central database. One or more profiles may be stored for a customer, such as a business profile, personal profile, or trip specific profiles. In this manner, when a user submits a search request, the management system generates a list of routings that satisfy the customer preference data. Furthermore, the management system may provide increased performance by reducing the number of search requests submitted by a customer.

Abstract: The invention relates to a group of novel pyrazole compounds of Formula (I): wherein: R1, R2, R3, M and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.