Patents by Inventor Thomas Bjarnsholt

Thomas Bjarnsholt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10603289
    Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: March 31, 2020
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
  • Publication number: 20180360773
    Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
    Type: Application
    Filed: May 15, 2018
    Publication date: December 20, 2018
    Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
  • Patent number: 9655840
    Abstract: The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein the product comprises at least one further antibacterial compound; a delivery system comprising a container connected to a means of delivery which is connected to a pad, wherein said container comprises a composition comprising acetic acid and said pad comprises a self-adhesive material; a kit comprising a dressing and an adhesive membrane, wherein the dressing comprises a composition comprising acetic acid; a method of treating a wound comprising a) applying acetic acid to the wound and b) applying a negative pressure to the wound.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: May 23, 2017
    Assignees: RIGSHOSPITALET, COPENHAGEN UNIVERSITY HOSPITAL, BISPEBJERG HOSPITAL
    Inventors: Michael Christian Givskov, Thomas Bjarnsholt, Klaus Kirketerp-Møller
  • Publication number: 20150273161
    Abstract: The present invention relates to a pre-filled disposable injection device and a needle cannula in combination. The prefilled disposable injection device (1) is made from a housing (2) containing a non-exchangeable cartridge (10) for storing a liquid drug sufficient for a number of injections. The proximal end of the pre-filled injection device (1) carries the dose setting button (3) and the distal end carries the needle cannula (20) having a lumen (21) through which the settable dose is expelled. The distal end (23) of the needle cannula (20) is covered by a telescopic needle covering shield (30) which shield (30) can operate between a first position covering the tip (24) of the needle cannula (20) and a second retracted position allowing an injection to be performed.
    Type: Application
    Filed: October 22, 2013
    Publication date: October 1, 2015
    Inventors: Henrik Bengtsson, Mads Schenstroem Stefansen, Lars Eilertsen, Henning Graeskov, Claus Moser, Thomas Bjarnsholt
  • Publication number: 20140303070
    Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
    Type: Application
    Filed: December 7, 2011
    Publication date: October 9, 2014
    Applicant: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
  • Publication number: 20140046276
    Abstract: The present invention pertains to use of sodium diacetate (NaHAc2) as an antimicrobial agent against bacteria growing in biofilms. The aspects of the invention include a wound care product comprising sodium diacetate, a kit comprising a wound care product, and a method of treating an infected wound.
    Type: Application
    Filed: April 18, 2012
    Publication date: February 13, 2014
    Applicants: RIGSHOSPITALET COPENHAGEN UNIVERSITY HOSPITAL, BISPEBJERG HOSPITAL, DANMARKS TEKNISKE UNIVERSITET
    Inventors: Thomas Bjarnsholt, Klaus Kirketerp-Moller, Michael Christian Givskov
  • Publication number: 20130060208
    Abstract: The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein the product comprises at least one further antibacterial compound; a delivery system comprising a container connected to a means of delivery which is connected to a pad, wherein said container comprises a composition comprising acetic acid and said pad comprises a self-adhesive material; a kit comprising a dressing and an adhesive membrane, wherein the dressing comprises a composition comprising acetic acid; a method of treating a wound comprising a) applying acetic acid to the wound and b) applying a negative pressure to the wound.
    Type: Application
    Filed: December 21, 2010
    Publication date: March 7, 2013
    Applicants: RIGSHOSPITALET, COPENHAGEN UNIVERSITY HOSPITAL, BISPEBJERG HOSPITAL, DANMARKS TEKNISKE UNIVERSITET
    Inventors: Michael Christian Givskov, Thomas Bjarnsholt, Klaus Kirketerp-Møller
  • Publication number: 20110245148
    Abstract: The present invention relates to a composition comprising: a) 0.01-20% wt/wt acetic acid and b) a physiologically tolerable buffer capable of maintaining acetic acid at a pH in the range of 2-7; and use of such a composition as an antimicrobial agent.
    Type: Application
    Filed: June 23, 2009
    Publication date: October 6, 2011
    Applicants: DANMARKS TEKNISKE UNIVERSITET, BISPEBJERG HOSPITAL, RIGSHOSPITALET COPENHAGEN UNIVERTISY HOSPITAL
    Inventors: Michael Christian Givskov, Thomas Bjarnsholt, Preben Homoe, Niels Hoiby, Peter Østrup Jensen, Helle Krogh Johansen, Klaus Kirketerp-Moller