Abstract: This disclosure relates to a method and a system for processing grapes. An example system includes a simulated moving bed (SMB) device configured to receive a feed stream and an eluent stream as inputs and provide an extract stream and a raffinate stream as outputs. The feed stream includes a grape juice, the extract stream includes a high-sugar grape juice, and the raffinate stream includes a low-sugar grape juice. The system also includes fermentation equipment configured to produce a low-alcohol wine from the low-sugar grape juice.

Abstract: The disclosure provides compositions, methods, and systems for modulating expression of target genes (e.g., target endogenous genes). Complexes of the disclosure can be useful for bringing one or more heterologous gene effectors into close proximity with a target gene or target gene regulatory sequence, thereby facilitating modulation of an expression or activity level of the target gene. The disclosure provides, for example, compositions, systems, and methods for high throughput screens to identify heterologous gene effector domains and complexes of the effector domains with guide moieties to modulate expression of particular target gene(s). The disclosure also provides complexes identified by systems disclosed herein that can be employed for other purposes, such as research or as therapeutics.

Abstract: The disclosure provides systems, compositions, methods for regulating aberrant expression of a target gene in cell (e.g., a muscle cell), to treat or ameliorate a disease or a condition in a subject (e.g., muscular dystrophy, such as Facioscapulohumeral Muscular Dystrophy (FSHD)).

Abstract: Provided herein are a system and method for investing, allocating and periodically distributing pooled capital between investors sorted into a plurality of cohorts based on one or more of age, gender, and investor type. The system and method described herein may periodically distribute to investors capital generated from investment returns and mortality of the investors, as will be described in greater detail below. The system may include at least one computing device that provides a computing platform to enable fund managers and, in some embodiments, individual or retail investors, to interface with the system. The platform may guide individual investors through an onboarding process involving collection of information about the investor, such as age, gender and investor type.

Abstract: A system and method for automated blending of hydrogen gas with traditional fuels, such as natural gas, to produce a consistent stream of precision-blended flow with a single customizable, movable and modular unit that is automatically controlled, is disclosed. The system and method includes a self-contained modular unit, automatic flow control computers and systems, which are configured to automatically adjust the hydrogen blend for variable flow and pressures present in an existing distribution system, varying hydrogen and natural gas flow rates to maintain a repeatable percentage of hydrogen without manual operation.

Abstract: This disclosure relates to a method and a system for processing grapes. An example system includes a simulated moving bed (SMB) device configured to receive a feed stream and an eluent stream as inputs and provide an extract stream and a raffinate stream as outputs. The feed stream includes a grape juice, the extract stream includes a high-sugar grape juice, and the raffinate stream includes a low-sugar grape juice. The system also includes fermentation equipment configured to produce a low-alcohol wine from the low-sugar grape juice.

Abstract: A barrier connector for a concrete structure includes a base plate having a plurality of spaced apart openings. A plurality of anchor bolts is disposed through respective ones of the plurality of openings. Each of the anchor bolts has a feature at one longitudinal end extending away from a longitudinal axis of the anchor bolt. A lock nut disposed on a threaded portion of each anchor bolt on one side of the base plate. A threaded coupling is attached to the threaded portion of each anchor bolt on an opposed side of the base plate to the anchor nut, wherein the anchor bolts are affixed to the base plate without welding.

Abstract: The invention provides methods of simultaneously detecting one or more biomarkers associated with one or more platelets in a platelet sample by contacting the sample with one or more metal-tagged probes or mixtures thereof; washing the sample to remove unbound probes; and analyzing the sample by mass cytometry to simultaneously detect binding of the one or more metal-tagged probes or mixtures thereof to one or more biomarkers associated with the one or more platelets. Compositions, panels and kits for use with the methods described herein are also provided.

Abstract: A computer-implemented method, a system, and a network include receiving network data from a network and non-network sourced data from one or more external sources relative to the network; performing data mining on the network data and the non-network sourced data; developing a predictive analytics model based on the data mining; and performing predictive analytics on the network data and the non-network sourced data using the predictive analytics model to detect likely future failures in the network. The network can include a Software Defined Network (SDN) operating at any of Layers 0, 1, 2 and/or 3.

Abstract: A method and system for blending biogas with conventional fuel in which the fuel blend is automatically adjusted for lower biogas flows and methane concentrations by introducing higher concentrations of conventional fuels. The system is able to automatically adjust the fuel blend, thereby eliminating the requirement for manual intervention, and producing a variable blended biogas that can be utilized within existing natural-gas fired combustion units such as boilers, furnaces, heaters, etc., as well as enabling automatic adjustment and operation, maximum usage of biogas, and integration with combustion unit controls. Using all available biogas to provide energy also minimizes the need for flaring unused biogas.

Abstract: A network element, configured to operate in a network to provide various network functions therein, includes a main processor communicatively coupled to a main memory, wherein the main processor is configured to perform Operations, Administration, Maintenance, and Provisioning (OAM&P) associated with the network element, wherein the main processor is accessible through one or more access techniques; and a supervisory plane comprising a secure processor and a secure memory communicatively coupled thereto, wherein the supervisory plane is separate from and communicatively coupled to the main processor and the main memory, the supervisory plane is configured to allow secure, direct access to the main processor and the main memory.

Abstract: According to one embodiment, an apparatus comprises a substrate, a touch sensor, and a cover lens. The touch sensor is disposed on the substrate. A conductive mesh forms portions of the touch sensor, and the conductive mesh comprises fine lines of metal. The cover lens is coupled to the touch sensor and is at most 0.4 mm thick. The cover lens comprises plastic.

Abstract: A network element, configured to operate in a network to provide various network functions therein, includes a main processor communicatively coupled to a main memory, wherein the main processor is configured to perform Operations, Administration, Maintenance, and Provisioning (OAM&P) associated with the network element, wherein the main processor is accessible through one or more access techniques; and a supervisory plane comprising a secure processor and a secure memory communicatively coupled thereto, wherein the supervisory plane is separate from and communicatively coupled to the main processor and the main memory, the supervisory plane is configured to allow secure, direct access to the main processor and the main memory.

Abstract: A computer-implemented method, a system, and a network include receiving network data from a network and non-network sourced data from one or more external sources relative to the network; performing data mining on the network data and the non-network sourced data; developing a predictive analytics model based on the data mining; and performing predictive analytics on the network data and the non-network sourced data using the predictive analytics model to detect likely future failures in the network. The network can include a Software Defined Network (SDN) operating at any of Layers 0, 1, 2 and/or 3.

Abstract: Active power factor correction can be used to reduce input harmonics in an aircraft power distribution system. In an embodiment, one or more power factor correction (PFC) units can be placed in a power distribution system to profile an input signal. Each PFC unit can include a converter, such as an AC-DC converter, and can be placed in the power system bus on the input side of the load. In an embodiment, a PFC unit can include a boost rectifier topology with active power factor correction for harmonics elimination.

Abstract: An LED (Light Emitting Device) light source (100), a pulse controller or pulse control module (130) for an LED light source, and a method are provided, for controlling relative timing and phase of LED light pulse generation and operation of peripheral devices, relative to a common timing reference. A system is provided comprising a pulse controller (130) for controlling synchronization of multiple LEDs (144) and/or other devices and peripherals (164), relative to a common timing reference. The pulse controller (130) comprises a processor (131) that programmatically executes a time based sequence of digital control signals (141) from received inputs (121) indicative of a pulse generation sequence.

Abstract: According to one embodiment, an apparatus comprises a substrate, a touch sensor, and a cover lens. The touch sensor is disposed on the substrate. A conductive mesh forms portions of the touch sensor, and the conductive mesh comprises fine lines of metal. The cover lens is coupled to the touch sensor and is at most 0.4 mm thick. The cover lens comprises plastic.

Abstract: An LED (Light Emitting Device) light source (100), a pulse controller or pulse control module (130) for an LED light source, and a method are provided, for controlling relative timing and phase of LED light pulse generation and operation of peripheral devices, relative to a common timing reference. A system is provided comprising a pulse controller (130) for controlling synchronization of multiple LEDs (144) and/or other devices and peripherals (164), relative to a common timing reference. The pulse controller (130) comprises a processor (131) that programmatically executes a time based sequence of digital control signals (141) from received inputs (121) indicative of a pulse generation sequence.

Abstract: A computer-implemented method of creating enhancements in a computer game for a recipient experiencing a performance, the method including: selecting an enhancement to apply to a recipient; modifying the enhancement; and applying the modified enhancement to the recipient, wherein the modified enhancement is effective for a fixed duration of time proportional to the time spent by the recipient experiencing the performance. Keywords include MMO, buffs, packages and performance.

Abstract: Method and system for blending biogas with conventional fuel in which the fuel blend is automatically adjusted for lower biogas flows and methane concentrations by introducing higher concentrations of conventional fuels. The system is able to automatically adjust the fuel blend, thereby eliminating the requirement for manual intervention, and producing a variable blended biogas that can be utilized within existing natural-gas fired combustion units such as boilers, furnaces, heaters, etc., as well as enabling automatic adjustment and operation, maximum usage of biogas, and integration with combustion unit controls. Using all available biogas to provide energy also minimizes the need for flaring unused biogas.