Abstract: Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously.

Abstract: Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

Abstract: The present invention provides multitargeting bispecific antigen-binding molecules characterized by comprising a first and a second bispecific entity each comprising a domain binding to target, a second domain binding to an extracellular epitope of the human and the Macaca CD3? chain, wherein both bispecific entities are linked to each other by a spacer which spaces apart the first and the second bispecific entity. Moreover, the invention provides a polynucleotide, encoding the multitargeting bispecific antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Abstract: A bridge-supported tool for opening and closing lids located on top of railcars. The bridge has two sides and a cross member between the sides that moves along the sides, the cross member supports a tool carriage that moves along the cross member, the tool carriage has a tool engagement interface for retaining a selected tool and the interface is vertically moveable, such that the tool is moveable to any selected location in the space defined by the bridge. A controller can be used to direct the positioning of the tool by controlling the movements of the cross member, tool carriage and tool engagement interface.

Abstract: A polypropylene composition made from or containing: A) from 88.0 wt. % to 98.0 wt. %, of a random copolymer of propylene containing from 0.8 wt. % to 4.8 wt. % of 1-hexene derived units; the random copolymer of propylene having: a Melt Flow Rate: measured according to ISO 1133 (230° C., 5 Kg) ranging from 0.5 to 4.4 g/10 min; and B) from 2.0 wt. % to 12.0 wt. % of a terpolymer of propylene ethylene and 1-hexene having a content of ethylene derived units ranging from 35 wt. % to 60 wt.; and a content of 1-hexene derived units ranging from 1 wt. % to 6 wt. %; wherein the polypropylene composition has a Melt Flow Rate: measured according to ISO 1133 (230° C., 5 Kg) ranging from 0.5 to 5.0 g/10 min.

Abstract: A communication system for an aircraft, comprising a plurality of radios including at least a first radio that is operable in an encrypted mode for transmitting/receiving encrypted audio signals, and a second radio that is operable in a clear mode for transmitting/receiving unencrypted audio signals; an intercom system that interconnects the plurality of radios, wherein the plurality of radios is connected to the intercom system via a plurality of communication lines; and a security module that is configured to connect or disconnect selected ones of the plurality of communication lines for inhibiting simultaneous transmission of an encrypted audio signal via the first radio and an unencrypted audio signal via the second radio.

Abstract: The invention provides a surge protector, in particular for information technology and/or communications technology systems, which is equipped with: a housing (ST, BT; GT); a first input terminal (E1) for applying a first external voltage signal; a second input terminal (E2) for applying a second external voltage signal; a first output terminal (A1) for outputting the first external voltage signal; a second output terminal (A2) for outputting the second external voltage signal; a surge protection circuit device (G1, R1, Z1; G1, G2, R1, R2, Z1; G1, G2, R1, R2, Z1, Z2), at least part of which is provided on a circuit board (P) located in the housing (ST, BT; G); a first current path (ST1) for conducting the first external voltage signal from the first input terminal (E1) to the first output terminal (A1) bypassing the surge protection circuit device (G1, R1, Z1; G1, G2, R1, R2, Z1; G1, G2, R1, R2, Z1, Z2); a second current path (ST2) for conducting the second external voltage signal from the second input termin

Abstract: A bridge-supported tool for opening and closing lids located on top of railcars. The bridge has two sides and a cross member between the sides that moves along the sides, the cross member supports a tool carriage that moves along the cross member, the tool carriage has a tool engagement interface for retaining a selected tool and the interface is vertically moveable, such that the tool is moveable to any selected location in the space defined by the bridge. A controller can be used to direct the positioning of the tool by controlling the movements of the cross member, tool carriage and tool engagement interface.

Abstract: The present invention relates to a method for automatically planning maintenance in railway, the method comprising the steps of determining maintenance for different assets at different locations comprising determining at least one of a predicted technical condition of an asset and automatically optimizing the planning accordingly. Further, a railway planning system for automatically planning maintenance comprising a determining component for determining maintenance for different assets at different locations comprising a determining component for determining at least one of a predicted technical condition of an asset and an optimization component for automatically optimizing the planning accordingly.

Abstract: A machine tool is provided with two vertically oriented tool spindles that are arranged to hold tools and that are movable vertically in a first direction and horizontally in a second direction orthogonal to the first direction. Furthermore, the machine tool is provided with two workpiece support devices for clamping workpieces in place. At least one of the two workpiece support devices is movable horizontally in a third direction orthogonal to the first and the second direction. The two tool spindles and the two workpiece support devices are mounted on a common machine frame with a common working space, wherein the two tool spindles are movable parallel to one another in the second direction. The two tool spindles are facing one another.

Abstract: A polypropylene composition made from or containing: T1) 35-65 wt % of a recycled polypropylene mixture containing at least 80 wt % of rigid polypropylene items and having a purity of at least 90 wt %; T2) 20-50 wt % of an ethylene/propylene copolymer; T3) 5-20 wt % of a propylene/ethylene heterophasic copolymer composition made from or containing a) from 12 wt % to 52 wt % of a propylene homopolymer or a propylene/ethylene copolymer; and b) from 48 wt % to 88 wt % of a propylene/ethylene copolymer having a content of ethylene derived units ranging from 15 wt % to 42 wt %; wherein the propylene composition has a melt flow rate (ISO 1133 230° C./2.16 kg) ranging from 0.5 to 20 g/10 min.

Abstract: The invention relates to a device for detecting electrical currents on or in the vicinity of electrical conductors with at least one Reed switch as a magnetically responsive switch, which is arranged in the vicinity of the electrical conductor such that, when there is a significant current flow through the conductor, the magnetic field created triggers the switch and initiates an evaluation electronics connected to the switch.

Abstract: The invention relates to a system for protecting an electrical source or an electrical load, having a module comprising an input and an output, and an electronic safety device for the load that can be connected to the source. The module also comprises a voltage monitoring unit, a current monitoring unit, and semiconductor switching units and controllers associated therewith. According to the invention, in order to selectively apply the protection to the source or the protection to the load, a unit for electrical mirroring on the circuit side is provided so that in the event of source protection, the current monitoring unit is applied at the input end and the voltage monitoring unit is applied at the output end, and in the event of load protection, the voltage monitoring unit is applied at the input end and the current monitoring unit is applied at the output end.

Abstract: The invention refers to a recombinant human diamine oxidase (DAO) with decreased glycosaminoglycan binding affinity, wherein said DAO comprises at least one amino acid modification in the glycosaminoglycan (GAG) binding domain. The present invention also refers to the use of the DAO in the treatment of a condition associated with excess histamine, specifically in the treatment of chronic allergic diseases, more specifically in the treatment of anaphylaxis, anaphylactic shock, chronic urticaria, acute urticaria, asthma, hay fever, allergic rhinitis, allergic conjunctivitis, histamine intoxication, headache, atopic dermatitis inflammatory diseases, mastocytosis, mast cell activation syndrome (MCAS), pre-eclampsia, hyperemesis gravidarum, pre-term labor, peptic ulcers, acid reflux, pruritus, and sepsis.

Abstract: A machine tool is provided with two vertically oriented tool spindles that are arranged to hold tools and that are movable vertically in a first direction and horizontally in a second direction orthogonal to the first direction. Furthermore, the machine tool is provided with two workpiece support devices for clamping workpieces in place. At least one of the two workpiece support devices is movable horizontally in a third direction orthogonal to the first and the second direction. The two tool spindles and the two workpiece support devices are mounted on a common machine frame with a common working space, wherein the two tool spindles are movable parallel to one another in the second direction. The two tool spindles are facing one another.

Abstract: A machine tool is provided with two vertically oriented tool spindles that are arranged to hold tools and that are movable vertically in a first direction and horizontally in a second direction orthogonal to the first direction. Furthermore, the machine tool is provided with two workpiece support devices for clamping workpieces in place. At least one of the two workpiece support devices is movable horizontally in a third direction orthogonal to the first and the second direction. The two tool spindles and the two workpiece support devices are mounted on a common machine frame with a common working space, wherein the two tool spindles are movable parallel to one another in the second direction. The two tool spindles are facing one another.

Abstract: Circuit assembly for protecting a unit to be operated from a supply network against surges, comprising an input having a first and a second input connection, which are connected to the supply network, an output to which the unit to be protected can be connected, and a protective circuit which is placed between the first and the second input connections in order to limit the voltage applied thereto, said protective circuit comprising a power semiconductor device. The power semiconductor device includes at least one Zener element between the collector and the gate, or a digital-to-analog converter is placed between the collector and the gate of the power semiconductor device. The protective level of this type of protective circuit can be easily adjusted by setting the clamping voltage for the power semiconductor device.

Abstract: A polypropylene composition made from or containing: A) from 88.0 wt. % to 98.0 wt. %, of a random copolymer of propylene containing from 0.8 wt. % to 4.8 wt. % of 1-hexene derived units; the random copolymer of propylene having: a Melt Flow Rate: measured according to ISO 1133 (230° C., 5 Kg) ranging from 0.5 to 4.4 g/10 min; and B) from 2.0 wt. % to 12.0 wt. % of a terpolymer of propylene ethylene and 1-hexene having a content of ethylene derived units ranging from 35 wt. % to 60 wt.; and a content of 1-hexene derived units ranging from 1 wt. % to 6 wt. %; wherein the polypropylene composition has a Melt Flow Rate: measured according to ISO 1133 (230° C., 5 Kg) ranging from 0.5 to 5.0 g/10 min.

Abstract: The invention relates to a method for detecting electrical currents on or near electrical conductors with at least one reed switch as a magnetically responsive switch, which is arranged near the electrical conductor such that when there is a significant current flow through the conductor, the magnetic field created triggers the switch and initiates evaluation electronics connected to the switch. For the detection of surge current variables and differentiation between long-term pulsed currents and short-term pulsed currents, a plurality of reed switches is arranged at pre-determined, different, increasing distances from the electrical switch, the evaluation electronics determining the response and the switching times of the respective reed switches. The surge current variables are determined from the association of the determined values with the respective reed switch and the pulse shape from the switching time.

Abstract: The present invention relates to a method for automatically planning maintenance in railway, the method comprising the steps of determining maintenance for different assets at different locations comprising determining at least one of a predicted technical condition of an asset and automatically optimizing the planning accordingly. Further, a railway planning system for automatically planning maintenance comprising a determining component for determining maintenance for different assets at different locations comprising a determining component for determining at least one of a predicted technical condition of an asset and an optimization component for automatically optimizing the planning accordingly.