Abstract: A method of forming a conjugate of a sulfonamide and a polypeptide, the method comprising: a) Providing an activated sulfonamide, wherein the activated sulfonamide corresponds to Formula (I); b) Providing an aqueous solution of a polypeptide having a free amino group, wherein the aqueous solution optionally comprises an alcohol; c) Contacting the aqueous solution of b) with the activated sulfonamide of a); and d) Reacting the activated sulfonamide with the polypeptide having a free amino group, obtaining a solution comprising the conjugate of a sulfonamide and a polypeptide, wherein the sulfonamide is covalently bonded to the polypeptide. Also associated conjugates, processes, procedures, proinsulins and the like.

Abstract: New peptides as selective GIP receptor agonists The present invention relates to peptidic selective GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, hyperglycemia, as well as the treatment of disorders associated with nausea and vomiting.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: A method and a device for heat sealing multiple plies of a laminate from which gable top packaging can be produced, wherein the laminate has a carrier layer made of electrically non-conductive material and a sealing layer made of thermoplastic material on at least one surface of the laminate. To heat seal multiple plies of a laminate in a high-frequency alternating electric field, the alternating electric field is generated by a first lead of an HF voltage supply in a first sub-region of the sealing region and is generated by a second lead of the HF voltage supply, differing from the first lead, in at least a second sub-region of the sealing region, so that a different heat distribution is obtained over the sub-regions of the sealing region.

Abstract: A first data table and a second table to be joined is determined. The first data table and the second data table have a join attribute. Data blocks of the first data table are stored on a storage device. An attribute value information for the join attribute for the data block of the first data table is determined. At least one partition for the first data table and the second table is defined using at least the attribute value information on the join attribute. Each partition of the at least one partition has a respective partition range of values of the join attribute. A pair wise partition join is processed on a first partition range of the determined partition ranges.

Abstract: A first data table and a second table to be joined is determined. The first data table and the second data table have a join attribute. Data blocks of the first data table are stored on a storage device. An attribute value information for the join attribute for the data block of the first data table is determined. At least one partition for the first data table and the second table is defined using at least he attribute value information on the join attribute. Each partition of the at least one partition has a respective partition range of values of the join attribute. A pair wise partition join is processed on a first partition range of the determined partition ranges.

Abstract: A first data table and a second table to be joined is determined. The first data table and the second data table have a join attribute. Data blocks of the first data table are stored on a storage device. An attribute value information for the join attribute for the data block of the first data table is determined. At least one partition for the first data table and the second table is defined using at least he attribute value information on the join attribute. Each partition of the at least one partition has a respective partition range of values of the join attribute. A pair wise partition join is processed on a first partition range of the determined partition ranges.

Abstract: A filling machine for filling packaging containers made of cardboard composite material with products, in particular liquid foods, includes a gripper that removes a packaging jacket from a magazine only partially erected in the manner of a parallelogram by a guide and at least one of two retaining elements for accommodating an outer fold edge of the partially erected packaging jacket can be move back and forth between an initial position and an end position. The cross-section of the packaging jacket accommodated by the two retaining elements is rectangular in the end position of the movable retaining element.

Abstract: A first data table and a second table to be joined is determined. The first data table and the second data table have a join attribute. Data blocks of the first data table are stored on a storage device. An attribute value information for the join attribute for the data block of the first data table is determined. At least one partition for the first data table and the second table is defined using at least he attribute value information on the join attribute. Each partition of the at least one partition has a respective partition range of values of the join attribute. A pair wise partition join is processed on a first partition range of the determined partition ranges.

Abstract: A method and a device for heat sealing multiple plies of a laminate from which gable top packaging can be produced, wherein the laminate has a carrier layer made of electrically non-conductive material and a sealing layer made of thermoplastic material on at least one surface of the laminate. To heat seal multiple plies of a laminate in a high-frequency alternating electric field, the alternating electric field is generated by a first lead of an HF voltage supply in a first sub-region of the sealing region and is generated by a second lead of the HF voltage supply, differing from the first lead, in at least a second sub-region of the sealing region, so that a different heat distribution is obtained over the sub-regions of the sealing region.

Abstract: A first data table and a second table to be joined is determined. The first data table and the second data table have a join attribute. Data blocks of the first data table are stored on a storage device. An attribute value information for the join attribute for the data block of the first data table is determined. At least one partition for the first data table and the second table is defined using at least he attribute value information on the join attribute. Each partition of the at least one partition has a respective partition range of values of the join attribute. A pair wise partition join is processed on a first partition range of the determined partition ranges.

Abstract: A first data table and a second table to be joined is determined. The first data table and the second data table have a join attribute. Data blocks of the first data table are stored on a storage device. An attribute value information for the join attribute for the data block of the first data table is determined. At least one partition for the first data table and the second table is defined using at least he attribute value information on the join attribute. Each partition of the at least one partition has a respective partition range of values of the join attribute. A pair wise partition join is processed on a first partition range of the determined partition ranges.

Abstract: A rotary piston pump for the delivery of liquids and for the delivery of liquids containing solids. The rotary piston pump includes a pump housing which is provided with an inlet and an outlet. The pump housing includes a lining. Disposed in the pump housing, or inside the lining, are at least two counter-rotating rotary pistons, which form pump spaces during their rotation. During the rotational movement, the rotary pistons are sealed against one another, against the pump housing and against the lining. Disposed in the pump housing and/or in the lining, in the spatial vicinity of the inlet and/or the outlet, are means with which the pulsation can be reduced or even completely prevented.

Abstract: A rotary piston pump with at least two double- or multi-lobe rotary pistons rotating in opposite directions, the drive shafts whereof include seals, wherein the seals are constituted as slip ring seals or lip seals or stuffing-box seals, which in each case are disposed on the shaft shoulder belonging to the respective rotary piston, and one slip ring per seal is provided with a locking device, which includes a large number of fixing positions. The seals are pushed onto a tubular shoulder of the rotary piston, the rotary piston is introduced into the pump housing, the securing element is connected to the slip ring seal in a form-fit manner by rotation of the rotary piston and the shaft shoulder is then rigidly connected to the drive shaft.

Abstract: A method and a device for fixing and synchronizing rotary pistons in a rotary piston pump involves introducing the rotary pistons into the pump space of the rotary piston pump. A shaft stub of each rotary piston is then pushed through a pump rear wall onto a driveshaft provided for the respective rotary piston. The rotary pistons are aligned and synchronized in the pump space via a template, the template being fixed detachably to a pump housing. The shaft stubs of the respective rotary piston are connected, after the synchronization, in each case via a clamping device in a friction-locked manner to the respective driveshaft, outside the pump space.

Abstract: A combined vehicle brake having a hydraulically actuable driving brake and an electromechanically actuable parking brake device. In a brake housing, a hydraulic operating pressure space is bounded by a brake piston chargeable with hydraulic pressure medium to carry out normal braking. The brake piston is actuable along a longitudinal axis of the piston, and the parking brake device acts on the brake piston by a gearing converting the rotational movement of an electromechanical actuator into a translation movement and bringing about an actuation of the brake piston in order to carry out parking brake operations and keeping the brake piston in the actuated position. The gearing has a threaded spindle and a threaded nut which are in contact with each other via a plurality of rolling bodies. The frictional moment transmitted by the further axial bearing is higher than the returning torque of the threaded spindle.

Abstract: A combined vehicle brake having a hydraulically actuable driving brake and an electromechanically actuable parking brake device. In a brake housing, a hydraulic operating pressure space is bounded by a brake piston chargeable with hydraulic pressure medium to carry out normal braking. The brake piston is actuable along a longitudinal axis of the piston, and the parking brake device acts on the brake piston by a gearing converting the rotational movement of an electromechanical actuator into a translation movement and bringing about an actuation of the brake piston in order to carry out parking brake operations and keeping the brake piston in the actuated position. The gearing has a threaded spindle and a threaded nut which are in contact with each other via a plurality of rolling bodies. The frictional moment transmitted by the further axial bearing is higher than the returning torque of the threaded spindle.

Abstract: A rotary piston pump equipped with a motor having two counter-rotating rotary pistons. The two rotary pistons are housed in an oval pump housing. The two rotary pistons are arranged on a first output shaft and a second output shaft. The first output shaft and the second output shaft are driven and synchronized via at least one elastic element.