Abstract: A method for minimizing a deviation of a physical parameter of a blow-molded container from a target value comprises determining a physical parameter of a container assigned to a machine parameter value of a blow molding machine and an environmental condition, based on the physical parameter and the target value, determining a change in the machine parameter, based on an iteration process, determining an optimal machine parameter value for achieving a minimum deviation from the target value of the physical parameter of a blow-molded container, the iteration process comprising a first iteration step for determining a deviation from the target value of the physical parameter of a blow-molded container based on a change in the machine parameter value, and a second iteration step for determining an adjusted change in the machine parameter value based on the deviation of the physical parameter of a blow-molded container from the target value.

Abstract: A filter apparatus (10) has a plurality of filter elements (20) in a filter housing (12) having a filter inlet (50) for a fluid to be filtered and a filter outlet (52) for the filtered fluid. A pressure control device (42) has at least one control plate (58) located inside a connection chamber (14). The control plate laterally passes over individual upper element openings (54) of the filter element to be backwashed (20), in a predefinable sequence, covering the opening to an increasing degree and then exposing the opening again. A discharge opening (46) of the backwash device (44) is, at least in part, fluidically connected to a lower element opening (56) of the filter element (20) to be backwashed, as the pressure control device (42) moves towards the upper element opening (54).

Abstract: The present invention relates to a compound which can be used in the treatment of infections caused by SARS coronaviruses, e.g. by blocking the active site of the proteases 3CLpro and PLpro. The compound can be used as inhibitor or label as such or can be used in screening methods for profiling other inhibitors. Moreover, the present invention relates to a method of producing the compound.

Abstract: The present invention relates to a compound, which can be used in the prevention and treatment of infections with pathogenic Neisseria species, in particular N. gonorrhoeae and N. meningitidis (the gonococcus and the meningococcus, respectively), and other pathogenic bacteria (e.g. Haemophilus species or Moraxella catarrhalis), and which can be used for disinfecting a substrate from said bacteria. Moreover, the present invention relates to a corresponding pharmaceutical composition comprising said compound.

Abstract: The present invention relates to a compound which can be used in the treatment of infections with pathogenic bacteria, in particular pathogens mediating pathogenicity by quinolone dependent production of virulence factors, such as e.g. Pseudomonas aeruginosa and species of the genus Burkholderia, and which can be used for treating bacterial or chronic infections or can be used in combination with other anti-bacterial agents, such as antibiotics, to increase sensitivity of the bacteria for treatment of e.g. multiresistant strains in e.g. mammals.

Abstract: A filtering apparatus has filtering elements (11) in a filter housing (1), a filter inlet (7) and a filter outlet (9). During filtration, one of the filter elements (11) can be back-flushed by a back-flushing device (45, 49), having a pressure control device (19). The pressure control device has a hydraulic accumulator (19), with a fluid chamber (47) fillable during filtration with clean fluid and connectable for back-flushing via a back-flushing guide (45) to the clean side (29) of the filtering element (11) to be cleaned. For back-flushing, a further fluid chamber (48) of the hydraulic accumulator (19) is subjected to gas pressure. By resultant movement of a separator (59) of the hydraulic accumulator (19), the filling amount of the clean fluid is dispensed for the back-flushing.

Abstract: The present invention relates to a compound, which can be used in the prevention and treatment of infections with pathogenic Neisseria species, in particular N. gonorrhoeae and N. meningitidis (the gonococcus and the meningococcus, respectively), and other pathogenic bacteria (e.g. Haemophilus species or Moraxella catarrhalis), and which can be used for disinfecting a substrate from said bacteria. Moreover, the present invention relates to a corresponding pharmaceutical composition comprising said compound.

Abstract: The present invention relates to a compound, which can be used as an anti-bacterial and/or an anti-fungal agent as well as a zinc sensor. Moreover, the present invention relates to a pharmaceutical composition comprising said compound and methods for treating bacterial or fungal infections in mammals.

Abstract: The invention relates to a filter apparatus (10) comprising a plurality of filter elements (20) which can be received in a filter housing (12) having a filter inlet (50) for a fluid to be filtered and a filter outlet (52) for the filtered fluid, characterised in that a pressure control device (42) has at least one control plate (58) which, located inside a connection chamber (14), laterally passes over individual upper ele¬ment openings (54) of the filter element to be backwashed (20), in a predefinable se¬quence, covering the opening to an increasing degree and then exposing the opening again, and in that a discharge opening (46) of the backwash device (44) is, at least in part, fluidically connected to a lower element opening (56) of the filter element (20) to be backwashed, as the pressure control device (42) moves towards the upper element opening (54).

Abstract: The present invention relates to a compound, which can be used as an anti-bacterial and/or an anti-fungal agent as well as a zinc sensor. Moreover, the present invention relates to a pharmaceutical composition comprising said compound and methods for treating bacterial or fungal infections in mammals.

Abstract: A filter device includes at least one filter housing (1) in which at least one filter element (21) is arranged. Inside the filter housing (1), the filter element separates a clean side (9) from an untreated side (13). On the clean side (9) of the filter housing (1) at least one storage unit (3) having at least one movable separating element (47) is connected. The separating element divides the storage unit (3) into two working chambers or pressure chambers (49) (43).

Abstract: A separating device for separating a multiphase medium includes a cyclone separating device (1) that provokes an at least partial distribution of at least two phases of the medium with the formation of a vortex flow for the medium. Each phase having a lower density compared to the other phase is separated from the other phase and can be guided out of the separating device by a collecting device (35, 37).

Abstract: The present invention relates to beta-O/S/N fatty acids and derivatives thereof, in particular the compounds of formula (I) as described and defined herein, and their pharmaceutical use, including their use in the treatment or prevention of bacterial as well as protozoan infections, in particular the treatment or prevention of infections with Gram-positive and/or Gram-negative bacteria and infectious diseases caused by and/or related to Gram-positive and/or Gram-negative bacteria. The invention further relates to the use of these compounds for preventing or eliminating biofilms.

Abstract: A filtering apparatus with a plurality of filtering elements (9) which can be accommodated in a filter housing (1) having a filter inlet (45) for fluid to be filtered and a filter outlet (43) for the filtered fluid, wherein during the filtration operation, at least one of the filtering elements (9) can be back-flushed by means of a back-flushing device (13, 21) in order to dedust the effective filtering surface of said filtering element, the back-flushing device comprising a pressure control device (13) for assisting the back-flushing operation, is characterized in that the pressure control device comprises a hydraulic accumulator (13), the one fluid chamber (67) of which can be filled during the filtration operation with a quantity of dedusted fluid and can be connected for a back-flushing operation via a back-flushing guide (21) to the clean side (59) of the filtering element (9) to be dedusted, and in that, for a back-flushing operation, a further fluid chamber (79) of the hydraulic accumulator (13) can be

Abstract: A filtering apparatus with a plurality of filtering elements (11) which can be accommodated in a filter housing (1) having a filter inlet (7) for fluid to be filtered and a filter outlet (9) for the filtered fluid, wherein during the filtration operation, at least one of the filtering elements (11) can be back-flushed by means of a back-flushing device (45, 49) in order to dedust the effective filtering surface of said filtering element, the back-flushing device comprising a pressure control device (19) for assisting the back-flushing operation, is characterized in that the pressure control device comprises a hydraulic accumulator (19), the one fluid chamber (47) of which can be filled during the filtration operation with a quantity of dedusted fluid and can be connected for a back-flushing operation via a back-flushing guide (45) to the clean side (29) of the filtering element (11) to be dedusted, and in that, for a back-flushing operation, a further fluid chamber (48) of the hydraulic accumulator (19) can b

Abstract: The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.

Abstract: Methods of treating or reducing biofilms, treating a biofilm-related disorder, and preventing biofilm formation using polyamines is described.

Abstract: Methods of treating or reducing biofilms, treating a biofilm-related disorder, and preventing biofilm formation using polyamines is described.

Abstract: The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.

Abstract: The invention relates to a separating device for separating a multiphase medium, comprising a cyclone separating device (1) that provokes an at least partial distribution of at least two phases of said medium with the formation of a vortex flow for the medium. The invention is characterized in that each phase, which has a lower density compared to the respective other phase, is separated from said other phase and can be guided out of the separating device by means of a collecting device (35, 37).