Abstract: The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Abstract: Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Abstract: This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.

Abstract: The invention relates to a device and a method for optically measuring the concentrations of a substance contained in a fluid medium. With the solution according to the invention the accuracy of measurement is to be increased in accordance with the object over a greater period without any additional calibration measurements, and ageing of a fluorescent substance within a layer is to be taken into consideration, in particular, and the long-time drift of such a measurement system is to be reduced. To achieve this, a layer containing such a known fluorescent substance or layer system are employed in which fluorescence is excited. The fluorescence changes depending on a substance concentration or a pH-value, and the intensity varying correspondingly in time or phase shift of the fluorescent light is allowed to be measured with at least one optical detector with the known intensity or phase of the fluorescence exciting light.

Abstract: This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them.

Abstract: A device capable of transporting package sleeves in an upright position, from any of several filling lines to one or more filling machines, wherein said several filling lines are aligned parallel to each other. The device utilizes a manipulator capable of linear travel in a direction perpendicular to the plane of alignment of the filling lines, a swiveling unit for moving the package sleeves in a direction transverse to the direction of travel of the manipulator unit, and a gripper unit for gripping the package sleeves. The gripper unit is capable of supplying horizontal force to the package sleeves to enable their transport in an upright position. The gripper unit also has means to clamp to the loading magazine of the filling machine and to cause the horizontal transfer of the package sleeves thereto. By use of the present device, semi-automatic or automatic loading of package sleeves to one or more filling machines is possible.