Abstract: A device for processing cardiac signals including a memory receiving input data sets including a plurality of P wave segments associated with an electrocardiogram track and with an acquisition time window, and a plurality of coronary sinus signals associated with the same acquisition time window and having one or more activation sequence(s). The device includes an extractor arranged, for a given input data set, to determine for at least some P wave segments of the given input data set a wave polarity profile type, at least one extremum feature. The extractor is also arranged to determine, for each group of track P wave data, a set of track P wave features comprising a polarity profile type, a data set extremum feature value for each calculated extremum feature type and an integral value determined based on the data of the corresponding group of track P wave data.

Abstract: The invention relates to a device for processing intracardiac signals, which comprises a memory unit (4) arranged to receive electrocardiogram data and synchronised electrogram data, a detector (6) arranged to analyse the electrocardiogram data and to detect QRS wave instants therein, an analyser (8) arranged to perform a wavelet transform of the electrogram data, an extractor (10) arranged to collect coefficients from the wavelet transform, each associated with a QRS wave instant detected by the detector (6), and to store them in a buffer (14), and a composer (12) arranged to extract a QRS fingerprint signal from the buffer (14) and subtract it from the wavelet transform at the QRS wave instants, and to output denoised electrogram data by inverse wavelet transform of the resulting signal.

Abstract: The inventions described herein relate to systems and methods directed to data-driven, continuous, and adaptable learning approaches to analyzing atrial tachycardia (AT) in a human body. The systems and methods may create an AT profile that automatically evolves such that a subsequent change in the AT is more accurately recognized and categorized.

Abstract: Techniques for generating microtissues, including a micro-fabricated platform including at least one micro-well including a plurality of micro-cantilevers coupled thereto and surrounded by a plurality of ridges, each micro-cantilever including a cap at a terminal end thereof. The platform can be immersed in a suspension of cells. The suspension of cells can be driven into at least one micro-well, and the ridges can be de-wetted to remove excess suspension and isolate the suspension of cells in each micro-well. The cells can be driven in the suspension of each micro-well toward a top surface of the suspension, which can be polymerized to form a matrix. The cells can be cultivated to spontaneously compact the matrix such that the micro-cantilevers anchor and constrain the contracting matrix to form a band of microtissue that spans across the micro-cantilevers.

Abstract: Techniques for generating microtissues, including a micro-fabricated platform including at least one micro-well including a plurality of micro-cantilevers coupled thereto and surrounded by a plurality of ridges, each micro-cantilever including a cap at a terminal end thereof. The platform can be immersed in a suspension of cells. The suspension of cells can be driven into at least one micro-well, and the ridges can be de-wetted to remove excess suspension and isolate the suspension of cells in each micro-well. The cells can be driven in the suspension of each micro-well toward a top surface of the suspension, which can be polymerized to form a matrix. The cells can be cultivated to spontaneously compact the matrix such that the micro-cantilevers anchor and constrain the contracting matrix to form a band of microtissue that spans across the micro-cantilevers.