Abstract: A reusable delivery container comprising an enclosure for containing an item; a closure selectively allowing access to the enclosure; a display on an outer surface of the container, comprising configurable electronic ink for displaying delivery information; an electronic lock for selectively securing the closure, the electronic lock having updatable unlock criteria; a 5 receiver configured to receive data communications, the data communications comprising at least lock data; power circuitry for providing power from a power source to the display, the electronic lock, and the receiver; and control circuitry arranged to control the electronic lock and update the unlock criteria, based on lock data received by the receiver.

Abstract: A reusable delivery container comprising an enclosure for containing an item; a closure selectively allowing access to the enclosure; a display on an outer surface of the container, comprising configurable electronic ink for displaying delivery information; an electronic lock for selectively securing the closure, the electronic lock having updatable unlock criteria; a receiver configured to receive data communications, the data communications comprising at least lock data; power circuitry for providing power from a power source to the display, the electronic lock, and the receiver; and control circuitry arranged to control the electronic lock and update the unlock criteria, based on lock data received by the receiver.

Abstract: Direct slicing of CAD models to generate process planning instructions for solid freeform fabrication may overcome inherent disadvantages of using STL format in terms of the process accuracy, ease of file management, and incorporation of multiple materials. This paper will present the results of our development of a direct slicing algorithm for layered freeform fabrication. The direct slicing algorithm was based on a neutral, international standard (ISO 10303) STEP-formatted NURBS geometric representation and is intended to be independent of any commercial CAD software. The following aspects of the development effort will be presented: 1) Determination of optimal build direction based upon STEP-based NURBS models; 2) Adaptive subdivision of NURBS data for geometric refinement; and 3) Ray-casting slice generation into sets of raster patterns.

Abstract: The invention is directed to a bone putty composition comprising a carrier formulation comprising water and a carrier substance, and granules wherein said bone putty composition exhibits gel-like Theological properties throughout the temperature range between about body temperature and temperatures approaching about 0° C. The bone putty composition further exhibits reverse phase Theological behavior in at least a portion of the same temperature range. The granules may comprise tricalcium phosphate (hereinafter “TCP”) or other calcium phosphates, they may be porous, and they are suspended in the carrier formulation. In one embodiment of the invention, the bone putty composition withstands exposure to certain temperatures below about room temperature without precipitation of the granules from suspension.

Abstract: The present invention is directed to a biostructure comprising an osteoconductive member and an osteoinductive material. The osteoinductive material may be located within a cavity in the osteoconductive material. In one aspect of the invention the osteoinductive material is demineralized bone matrix and the osteoconductive member comprises tricalcium phosphate.

Abstract: A spinal cage insert for a spinal cage is provided. The spinal cage insert has a shape suitable to be inserted into and fit closely in an interior of the spinal cage. The insert may comprise a member of the calcium phosphate family. The spinal cage insert may be made to a desired shape of porous ceramic, and it may include channels and/or surface features. Various shapes of filler pieces are also provided, wherein the filler pieces may be suitable to augment external regions of vertebrae which have been fused to each other so as to promote build-up of bone. The spinal cage insert and/or the filler pieces may be osteoconductive and may also contain osteoinductive substances or material. The articles may also contain cavities suitable for containing particles of demineralized bone matrix (DBM). Methods of use and methods of manufacturing the spinal cage insert and filler pieces are also provided.

Abstract: A bone graft that is made at least partially of synthetic material or demineralized bone matrix and is manufactured in suitable shape and/or dimensions to augment an alveolar ridge. The bone graft may be such as to augment both a portion of the crest of the alveolar ridge and a portion of at least one side of the alveolar ridge. The graft may include at least one hole for the intended position of an implant base, and/or at least one hole for attachment hardware. The graft may be manufactured to standard dimensions or it may be manufactured to patient-unique dimensions which may be determined radiographically prior to surgery and prior to manufacturing of the bone graft. The bone graft may be able to be carved for dimensional adjustment during surgery. The bone graft may have composition and/or local geometry which varies from one place to another, and may have a particular composition and/or local geometry at places intended to adjoin natural bone.

Abstract: The invention is directed to shaped bone void filler pieces having defined porosity. In embodiments of the invention, the shaped bone void filler pieces are presented substantially as wedges, wafers, and axisymmetric bone void filler pieces. The bone void filler pieces further comprise surface and internal features such as recesses, channels, and/or voids. The bone void filler pieces optionally comprise demineralized bone matrix. The invention further is directed to methods of making and methods of using the bone void filler pieces. In another embodiment of the invention, the bone void filler pieces are produced using three dimensional printing methods. In yet another embodiment of the invention, the bone void filler pieces are manufactured with selected porogens integrated therein, which optionally are decomposed following production through a heat-mediated decomposition process, resulting in voids in the bone void filler spaces previously occupied by the porogen(s).

Abstract: A bone graft that is made at least partially of synthetic material or demineralized bone matrix and is of a suitable shape to fill a lower portion of a patient's maxillary sinus. The graft may be manufactured to patient-unique dimensions that may be determined radiographically prior to surgery and prior to manufacturing of the bone graft. Other aspects of the invention are a method of manufacture of the bone graft, and methods of installing the bone graft. The installation may make use of patient-unique templates to guide certain cutting operations. Another aspect of the invention is a kit comprising the bone graft, tools for its installation, templates and possibly other surgical items.

Abstract: A bone graft that is made at least partially of synthetic material and is of a suitable shape to fill a recess around the base of an ailing/failing endosseous implant. The bone graft may be pre-manufactured in the suitable shape. The invention also comprises a method of installing either such a bone graft or any other type of filler. The invention also comprises various types of bone graft profiler tools suitable for preparing the recess, and optionally an alignment post to assist in the use of the bone graft profiler tool(s). The dimensions of the bone graft profiler tool(s) and the dimensions of the bone graft and the dimensions of the alignment post may be chosen to have defined geometric relationships with respect to each other, with respect to the dimensions of the existing implant base, and with respect to the extent of bone deterioration at a particular implant site in a particular patient.