Patents by Inventor Thomas Braschler

Thomas Braschler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240382650
    Abstract: The composition comprises a polyol crosslinked with a) a multifunctional epoxide; or b) an epihalohydrin; or c) a molecule or crosslinker mixture comprising multiple epihalohydrin and/or epoxide groups or molecules. The composition has a number N1 of effective ether crosslinks per crosslinker molecule as calculated by subtracting 1 from the average number of distinct polyol repeat units bound per crosslinker molecule. The remaining reactive groups on the crosslinker are ineffective in crosslinking and provide a number N2 of pendant groups per crosslinker molecule. Among the N2 groups per crosslinker there are N3 groups per crosslinker that are unreacted or otherwise retain reactivity against nucleophiles. The relationship between N1 and N2 is: N1>0.35 (N1+N2).
    Type: Application
    Filed: July 30, 2024
    Publication date: November 21, 2024
    Inventors: Thomas Braschler, Amelie Beduer, Patrick Burch
  • Patent number: 12109330
    Abstract: The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: October 8, 2024
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Amelie Barbara Hildegarde Beduer, Thomas Braschler, Philippe Renaud, Giorgio Pietramaggiori, Saja Scherer
  • Publication number: 20240301357
    Abstract: The present invention is directed to a substrate material for the formation of cell spheroids/organoids and uses thereof. The invention further relates to methods of preparation of such a substrate material and related tools and uses thereof, methods using such a substrate material for the formation of cell spheroids and resulting spheroids and uses thereof.
    Type: Application
    Filed: January 17, 2022
    Publication date: September 12, 2024
    Inventors: SANAE EL-HARANE, OLIVIER PREYNAT-SEAUVE, KARL-HEINZ KRAUSE, STÉPHANE DURUAL, ALI MODARRESSI, THOMAS BRASCHLER
  • Patent number: 12059507
    Abstract: The composition comprises a polyol crosslinked with a) a multifunctional epoxide; or b) an epihalohydrin; or c) a molecule or crosslinker mixture comprising multiple epihalohydrin and/or epoxide groups or molecules. The composition has a number N1 of effective ether crosslinks per crosslinker molecule as calculated by subtracting 1 from the average number of distinct polyol repeat units bound per crosslinker molecule. The remaining reactive groups on the crosslinker are ineffective in crosslinking and provide a number N2 of pendant groups per crosslinker molecule. Among the N2 groups per crosslinker there are N3 groups per crosslinker that are unreacted or otherwise retain reactivity against nucleophiles. The relationship between N1 and N2 is: N1>0.35 (N1+N2).
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: August 13, 2024
    Assignee: Volumina Medical SA
    Inventors: Thomas Braschler, Amelie Beduer, Patrick Burch
  • Publication number: 20240042102
    Abstract: A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric layers to obtain a stack of polymeric layers by possibly modulating the subzero temperature of the refrigerated support; c) optionally incubating the final polymeric structure at subzero temperature; and d) placing the produced cryogel at a temperature above 0° C., wherein each subsequent layer i) is deposited on the previous one after freezing of this latter; ii) is deposited on the previous one before the complete polymerization of this latter; and iii) is deposited with a temperature higher than the freezing temperature of the previously deposited layer. Cryogel scaffolds obtained from said method are also disclosed.
    Type: Application
    Filed: July 5, 2023
    Publication date: February 8, 2024
    Inventors: Amélie Barbara Hildegarde Béduer, Thomas Braschler, Philippe Renaud
  • Patent number: 11724006
    Abstract: A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric layers to obtain a stack of polymeric layers by possibly modulating the subzero temperature of the refrigerated support; c) optionally incubating the final polymeric structure at subzero temperature; and d) placing the produced cryogel at a temperature above 0° C., the method being characterized in that each subsequent layer i) is deposited on the previous one after freezing of this latter; ii) is deposited on the previous one before the complete polymerization of this latter; and iii) is deposited with a temperature higher than the freezing temperature of the previously deposited layer. Cryogel scaffolds obtained from the method of the invention are also disclosed.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: August 15, 2023
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Amélie Barbara Hildegarde Béduer, Thomas Braschler, Philippe Renaud
  • Publication number: 20230181794
    Abstract: The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises a three-dimensionally warped and branched sheet (2) where: (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; (iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions (4) where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2);
    Type: Application
    Filed: November 28, 2022
    Publication date: June 15, 2023
    Inventors: Amelie Beduer, Thomas Braschler, Philippe Renaud
  • Patent number: 11524092
    Abstract: The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: December 13, 2022
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Amélie Béduer, Thomas Braschler, Philippe Renaud
  • Publication number: 20220313871
    Abstract: The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.
    Type: Application
    Filed: January 7, 2022
    Publication date: October 6, 2022
    Inventors: Amelie Barbara Hildegarde Beduer, Thomas Braschler, Philippe Renaud, Giorgio Pietramaggiori, Saja Scherer
  • Publication number: 20220160936
    Abstract: The composition comprises a polyol crosslinked with a) a multifunctional epoxide; or b) an epihalohydrin; or c) a molecule or crosslinker mixture comprising multiple epihalohydrin and/or epoxide groups or molecules. The composition has a number N1 of effective ether crosslinks per crosslinker molecule as calculated by subtracting 1 from the average number of distinct polyol repeat units bound per crosslinker molecule. The remaining reactive groups on the crosslinker are ineffective in crosslinking and provide a number N2 of pendant groups per crosslinker molecule. Among the N2 groups per crosslinker there are N3 groups per crosslinker that are unreacted or otherwise retain reactivity against nucleophiles. The relationship between N1 and N2 is: N1>0.35 (N1+N2).
    Type: Application
    Filed: April 2, 2019
    Publication date: May 26, 2022
    Inventors: Thomas Braschler, Amelie Beduer, Patrick Burch
  • Patent number: 11219703
    Abstract: The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: January 11, 2022
    Assignee: École Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Amélie Barbara Hildegarde Béduer, Thomas Braschler, Philippe Renaud, Giorgio Pietramaggiori, Saja Scherer
  • Publication number: 20200384152
    Abstract: The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (
    Type: Application
    Filed: October 4, 2018
    Publication date: December 10, 2020
    Inventors: Amélie BÉDUER, Thomas BRASCHLER, Philippe RENAUD
  • Patent number: 10816823
    Abstract: The invention relates to a contact lens for use in the treatment of ocular inflammatory pathologies. The contact lens comprises a soft porous material coupled, in certain embodiments, with detoxifying agents. Said material and/or agents contact and neutralize inflammatory mediators present in the tear fluid of ocular pathologies patients. The nature and architecture of the soft porous material allows a greater contact area between the material itself and/or detoxifying agents with inflammatory mediators, in view of the reversible compression of the soft material that allows greater lachrymal fluid turnover and fluid exchange within the contact lens upon e.g. blinking.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: October 27, 2020
    Assignee: École Polytechnique Fédérale de Lausanne
    Inventors: Amélie Barbara Hildegarde Béduer, Thomas Braschler, Philippe Renaud, François Majo
  • Publication number: 20190336649
    Abstract: A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric layers to obtain a stack of polymeric layers by possibly modulating the subzero temperature of the refrigerated support; c) optionally incubating the final polymeric structure at subzero temperature; and d) placing the produced cryogel at a temperature above 0° C., the method being characterized in that each subsequent layer i) is deposited on the previous one after freezing of this latter; ii) is deposited on the previous one before the complete polymerization of this latter; and iii) is deposited with a temperature higher than the freezing temperature of the previously deposited layer. Cryogel scaffolds obtained from the method of the invention are also disclosed.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 7, 2019
    Inventors: Amélie Barbara Hildegarde BÉDUER, Thomas BRASCHLER, Philippe RENAUD
  • Publication number: 20180335647
    Abstract: The invention relates to a contact lens for use in the treatment of ocular inflammatory pathologies. The contact lens comprises a soft porous material coupled, in certain embodiments, with detoxifying agents. Said material and/or agents contact and neutralize inflammatory mediators present in the tear fluid of ocular pathologies patients. The nature and architecture of the soft porous material allows a greater contact area between the material itself and/or detoxifying agents with inflammatory mediators, in view of the reversible compression of the soft material that allows greater lachrymal fluid turnover and fluid exchange within the contact lens upon e.g. blinking.
    Type: Application
    Filed: May 4, 2016
    Publication date: November 22, 2018
    Inventors: Amélie Barbara Hildegarde Béduer, Thomas Braschler, Philippe Renaud, François Majo
  • Publication number: 20180250444
    Abstract: The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.
    Type: Application
    Filed: August 18, 2016
    Publication date: September 6, 2018
    Inventors: Amélie Barbara Hildegarde BÉDUER, Thomas BRASCHLER, Philippe RENAUD, Giorgio PIETRAMAGGIORI, Saja SCHERER
  • Patent number: 9995668
    Abstract: Microfluidic system comprising a space for containing a liquid and at least one lateral chamber in communication with said space, said lateral chamber containing a metal electrode. The lateral chamber and the space are designed to be filled by the same or different liquid when the system is active.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: June 12, 2018
    Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Philippe Renaud, Pontus Linderholm, Thomas Braschler, Nicolas Demierre, Urban Seger
  • Publication number: 20150037262
    Abstract: The invention relates to a device (1) for the transplantation of cells (3) in suspension comprising a support with at least one micro-cavity (2) containing or able to contain said suspension in direct contact with the object on which the cells are to be transplanted. The device is intended for application to human tissue or human or animal body, such as the eye, the gingiva, skin, a wound or a burn.
    Type: Application
    Filed: January 28, 2013
    Publication date: February 5, 2015
    Inventors: Yann Barrandon, Hubert Van Den Bergh, Philippe Renaud, Thomas Braschler, Julien Graber, Maia Caillier
  • Publication number: 20100006441
    Abstract: Microfluidic system comprising a space for containing a liquid and at least one lateral chamber in communication with said space, said lateral chamber containing a metal electrode. The lateral chamber and the space are designed to be filled by the same or different liquid when the system is active.
    Type: Application
    Filed: February 1, 2007
    Publication date: January 14, 2010
    Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
    Inventors: Philippe Renaud, Pontus Linderholm, Thomas Braschler, Nicolas Demierre, Urban Seger