Patents by Inventor Thomas Brian Lee

Thomas Brian Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6,8-Di-t-butyl-4-oxo-4H-1-benzopyran-2-carboxylic acid and derivative for the prevention of asthmatic symptoms
    Patent number: 4055654
    Abstract: There are described certain mono-chromone-2-carboxylic acids of formula, ##STR1## having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.
    Type: Grant
    Filed: January 2, 1976
    Date of Patent: October 25, 1977
    Assignee: Fisons Limited
    Inventors: Hugh Cairns, Albert Chambers, Thomas Brian Lee
  • Pharmaceutical compositions containing 4-carboxy-flavones
    Patent number: 4042708
    Abstract: There are provided processes for preparing compounds of the formula: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represent hydrogen, hydroxy, alkenyl, alkanoyl or alkyl, andX represents a hydrocarbon chain containing from 2 to 10 carbon atoms, optionally substituted by a hydroxy group) and pharmaceutically acceptable derivatives thereof, and pharmaceutical compositions containing them.The compounds are antagonists of the slow reacting substance of anaphylaxis.
    Type: Grant
    Filed: January 14, 1976
    Date of Patent: August 16, 1977
    Assignee: Fisons Limited
    Inventors: Thomas Brian Lee, David Norman Hardern, John Raymond Bantick
  • Chemical compounds
    Patent number: 4006245
    Abstract: There are provided compounds of formula I, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 may be the same or different, and are hydrogen, hydroxy, alkoxy, alkoxy substituted by phenyl, acyl, amino, acylamino, alkenyl, halogen, or alkyl, provided that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 are other than hydrogen and hydroxy,Or an adjacent pair of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 represent a chain --COCH=CH--O--,X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, andE is a carboxy group or a tetrazole group,And pharmaceutically acceptable derivatives thereof.The compounds are indicated for use as antagonists of SRS-A.
    Type: Grant
    Filed: January 29, 1975
    Date of Patent: February 1, 1977
    Assignee: Fisons Limited
    Inventors: Joachim Augstein, David Carter, Thomas Brian Lee
  • Benzopyran-2-carboxylic acids in the prevention of asthmatic symptoms
    Patent number: 3952104
    Abstract: There are described certain mono-chromone-2-carboxylic acids of formula, ##SPC1##Having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmacetuical compositions, for the treatment of asthma, containing the compounds.
    Type: Grant
    Filed: July 26, 1973
    Date of Patent: April 20, 1976
    Assignee: Fisons Limited
    Inventors: Hugh Cairns, Albert Chambers, Thomas Brian Lee
  • 4'-Carboxy-flavone
    Patent number: 3948955
    Abstract: There are provided compounds of the formula: ##SPC1##(wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represent hydrogen, hydroxy, alkenyl, alkanoyl or alkyl, andX represents a hydrocarbon chain containing from 2 to 10 carbon atoms, optionally substituted by a hydroxy group) and pharmaceutically acceptable derivatives thereof.The compounds are antagonists of the slow reacting substance of anaphylaxis.
    Type: Grant
    Filed: November 11, 1974
    Date of Patent: April 6, 1976
    Assignee: Fisons Limited
    Inventors: Thomas Brian Lee, David Norman Hardern, John Raymond Bantick