Abstract: A method for extracting metal cations from a biological fluid of a subject in need thereof employs dialyzing the subject with a dialysis device. The dialysis device includes a porous dialysis membrane, and a reservoir containing a perfusion fluid. At least one chelator which is either grafted on polymers or grafted on nanoparticles is present in the perfusion fluid. The cut-off threshold of the porous membrane is lower than the mass of the polymer or the nanoparticles to which the chelator is grafted. Metal cations from a biological fluid of a subject are extracted by complexing to the chelator during dialysis.

Abstract: The present disclosure relates to a functionalized statistic chitosan of weight average molecular mass between 100 kDa and 1000 kDa and of formula (I): wherein each Rc is independently a moiety comprising a chelating agent, each Z is independently a linker which is a single bond or a hydrocarbon chain containing between 1 and 12 carbon atoms, said hydrocarbon chain is linear or branched and optionally contains one or more unsaturations and one or more heteroatoms, x is between 0.005 and 0.7, preferably between 0.05 and 0.7, y is between 0.01 and 0.7, preferably between 0.05 and 0.2, the ratio y/x being greater than or equal to 0.05, preferably greater than or equal to 0.15, and the sum x+y being greater than or equal to 0.15, for use in the treatment of diseases characterized by local inflammation induced by and/or inducing a deregulation of metal homeostasis and increased oxidative stress, in a subject in need thereof.

Abstract: The invention concerns the field of medical devices, more particularly devices for joint extraction, within an organism, of at least one metal cation and at least one target molecule. In order to do this, the device comprises: a) at least one ligand exhibiting specific affinity for the target molecule; b) at least one means for extraction of the metal cation, said means being a perfusion fluid comprising at least one chelating agent, the perfusion fluid being contained in a dialysis or microdialysis system. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of the homeostasis of metals and/or target molecules in the organism, for example neurological diseases and/or proteinopathies.

Abstract: The invention relates to a method for treating dialysis water and fluids, in particular for capturing certain toxic metals such as lead, aluminium, chromium, nickel or cadmium, and preventing their passage into the blood of a patient during dialysis, i.e. hemodialysis, hemofiltration or hemodiafiltration. In particular, it relates to a dialysis composition, comprising a polymer with a weight-average molecular weight of 20 kDa and 1000 kDa having at least one chelating agent of at least one toxic exogenous metal such as lead, aluminium, chromium, nickel and cadmium, said polymer being present in a sufficient quantity to be at a concentration comprised between 0.01 mg/L and 10 mg/L when used during a dialysis of a patient.

Abstract: The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.

Abstract: The invention relates to a statistical polysaccharide with a weight-average molecular weight of between 100 kDa and 1000 kDa of the following formula (I): in which: each Rc independently represents a group containing a chelating agent, each Z independently represents a binder which may be a single bond or a hydrocarbon chain containing between 1 and 12 carbon atoms, said chain able to be either linear or branched and being able to contain one or more unsaturations and being able to contain one or more heteroatoms, preferably chosen from nitrogen, oxygen, sulfur and atoms of the halogen family, x is between 0.005 and 0.7, preferably between 0.05 and 0.7, and preferentially between 0.2 and 0.6, y is between 0.01 and 0.7, preferably between 0.05 and 0.2, the ratio of y/x being greater than or equal to 0.05, preferably greater than or equal to 0.15, and the sum of x+y being greater than or equal to 0.30, preferably greater than or equal to 0.35.

Abstract: The present invention relates to the field of medical devices, more particularly the field of devices for extracting circulating molecules from the blood of a mammal, and their therapeutic uses, in particular in treating sepsis, cytokine release syndrome and/or any other form of systemic inflammatory response or cytokine shock, caused by bacterial, parasitic, fungal or viral infections, in particular caused by a viral infection, for example coronaviruses with human respiratory tract tropism.

Abstract: The invention concerns the field of medical devices, more particularly devices for joint extraction, within an organism, of at least one metal cation and at least one target molecule. In order to do this, the device comprises: a) at least one ligand exhibiting specific affinity for the target molecule; b) at least one means for extraction of the metal cation, said means being a perfusion fluid comprising at least one chelating agent, the perfusion fluid being contained in a dialysis or microdialysis system. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of the homeostasis of metals and/or target molecules in the organism, for example neurological diseases and/or proteinopathies.

Abstract: The present invention relates to a method for determining the anionic charge density of at least one polymer present in a sample, according to the following steps: bringing the at least one polymer present in the sample into contact with, and enabling the interaction thereof with, a developer solution comprising lanthanide (III) ions, exciting the sample at an excitation wavelength ?exc and detecting, by time-resolved photoluminescence, a signal originating from the lanthanide (III) ions that have interacted with the at least one polymer at an emission wavelength ?em, and determining the anionic charge density of the at least one polymer of the sample using the signal detected at the emission wavelength ?em.

Abstract: The present invention relates to a method for determining the anionic charge density of at least one polymer present in a sample, according to the following steps: bringing the at least one polymer present in the sample into contact with, and enabling the interaction thereof with, a developer solution comprising lanthanide (III) ions, exciting the sample at an excitation wavelength ?exc and detecting, by time-resolved photoluminescence, a signal originating from the lanthanide (III) ions that have interacted with the at least one polymer at an emission wavelength ?em, and determining the anionic charge density of the at least one polymer of the sample using the signal detected at the emission wavelength ?em.

Abstract: The present invention relates to the field of medical devices, more particularly to devices for extracting metals from an organism. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of metal homeostasis in the organism, for example neurological diseases.

Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.

Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.

Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.

Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.

Abstract: The fluid tracers according to the invention have the advantage of producing a memory effect fluorescent signal, that is to say a signal modified as a function of the physico-chemical conditions encountered in the medium through which the nanoparticles pass after injection into the geological underground area. The analysis of fluorescent signals in the fluids collected after diffusion makes it possible to deduce therefrom information on the characteristics of the oil reservoir.

Abstract: This invention relates to the development of nanoparticles, which can be used as tracers, in order to track the movement of fluids injected into an oil reservoir. The injected fluids diffuse through a solid geological medium which constitutes the oil reservoir, thus making it possible to study this latter by following the path of the injected fluids. The objective is in particular to monitor the flows between the injection well(s) and the production well(s) and/or to evaluate the volumes of oil in reserve and water in the reservoir and ultimately to optimize oil exploration and exploitation.