Abstract: Described herein is a nozzle for controlling foam of a carbonated beverage product produced by a beverage making machine, and associated system and method of use thereof. The nozzle can include an engagement portion configured for releasable attachment with the beverage making machine. The nozzle can further include a funnel portion extending elongated from the engagement portion and that is configured to converge a flow of the carbonated beverage product. The nozzle can further include a dispense portion to establish a stream of the carbonated beverage product into a receptacle. An alignment feature on an exterior of the nozzle can define an offset between a wall of the receptacle and the stream of the carbonated beverage product.

Abstract: Disclosed herein are engineered RNAs and compositions comprising the same for treatment of diseases or conditions in a subject. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered RNAs, polynucleotides encoding the described engineered RNAs, or pharmaceutical compositions described here.

Abstract: Disclosed herein are engineered latent guide RNAs targeting LRRK2 and compositions comprising the same for treatment of diseases or conditions (e.g. Parkinson's Disease) in a subject. Also disclosed herein are methods of treating diseases or conditions (e.g. Parkinson's Disease) in a subject by administering engineered latent guide RNAs or pharmaceutical compositions described herein.

Abstract: An apparatus and method for inspecting an object by optical triangulation, where the signal of interest in a captured image corresponds to an interaction between a light beam and an environment surrounding the object rather than between a light beam and the object itself. The surrounding environment may be configured to interact in a manner that is detectable by filling it with a flowable scattering medium, e.g. a gas, mist or vapour comprising a suspension of fine particles in air. Light that is scattered by the flowable scattering medium is visible in a captured image. Where the flowable scattering medium is not present, e.g. because the object blocks it, the scattered signal is less. A boundary of a scattered signal region may thus provide information about the location of an object.

Abstract: An adjustable guide apparatus for guiding filamentary material from a reciprocating traverse onto a mandrel of a winding machine to form a coil. The adjustable guide apparatus includes a housing having a collar defining an inlet opening configured to receive filamentary material, and adjustable guides coupled to the housing defining a guide opening between the adjustable guides for passage of the filamentary material from the inlet opening. The apparatus also includes an adjuster configured to adjust relative spacing between the adjustable guides that defines the size of the guide opening.

Abstract: An apparatus and method for inspecting an object by optical triangulation, where the signal of interest in a captured image corresponds to an interaction between a light beam and an environment surrounding the object rather than between a light beam and the object itself. The surrounding environment may be configured to interact in a manner that is detectable by filling it with a flowable scattering medium, e.g. a gas, mist or vapour comprising a suspension of fine particles in air. Light that is scattered by the flowable scattering medium is visible in a captured image. Where the flowable scattering medium is not present, e.g. because the object blocks it, the scattered signal is less. A boundary of a scattered signal region may thus provide information about the location of an object.

Abstract: Compositions and methods for determining an optimal dose of a medication for a subject are described that include determining the subject's genotype for the CYP2C9 and VKORC1 genes and determining the dose of the medication based on the genotype. Articles of manufacture also are provided that include polynucleotides for genotyping.

Abstract: A method of providing a prognosis of colorectal cancer is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them.

Abstract: Methods, components, and kits for evaluating the effectiveness of methylation assays are presented as are methylation assays that include nucleotide sequence controls and methods of using them.