Abstract: A subtractive immunoassay for detecting the presence or absence of first and second analytes in a sample includes in the following order the steps of: a) conjugating a first detector antibody to the first analyte to tag the first analyte with a first detector tag; b) conjugating a first capture antibody to the first analyte to capture the first analyte to completely deplete the first analyte from the sample; c) conjugating a second detector antibody to the second analyte in the depleted sample to tag the second analyte with a second detector tag; d) conjugating a second capture antibody to the second analyte to capture the second analyte from the sample; e) detecting presence or absence of the first and second detector tags at the site of the first and second capture antibody, respectively, and thereby detecting the presence or absence of the first and second analytes in the sample.

Abstract: A subtractive immunoassay for detecting the presence or absence of first and second analytes in a sample includes in the following order the steps of: a) conjugating a first detector antibody to the first analyte to tag the first analyte with a first detector tag; b) conjugating a first capture antibody to the first analyte to capture the first analyte to completely deplete the first analyte from the sample; c) conjugating a second detector antibody to the second analyte in the depleted sample to tag the second analyte with a second detector tag; d) conjugating a second capture antibody to the second analyte to capture the second analyte from the sample; e) detecting presence or absence of the first and second detector tags at the site of the first and second capture antibody, respectively, and thereby detecting the presence or absence of the first and second analytes in the sample.

Abstract: The invention concerns a distraction appliance for orthodontic, orthognathic and maxillofacial surgery purposes on the mandible for the distraction of a frontal bone segment, wherein the appliance is formed by a first distractor module and a second distractor module, wherein the first distractor module is essentially u-shaped, approximated to a dental arch, and has a mid-segment and on both sides of it an end-segment, wherein the corresponding end-segment is connected to the mid-segment by means of a linear distraction element and wherein each end-segment provides fixation parts, and wherein the second distractor module is related to a frontal bone segment to be moved, guiding the same and having fixation parts.

Abstract: The invention concerns a distraction appliance for orthodontic, orthognathic and maxillofacial surgery purposes on the mandible for the distraction of a frontal bone segment, wherein the appliance is formed by a first distractor module and a second distractor module, wherein the first distractor module is essentially u-shaped, approximated to a dental arch, and has a mid-segment and on both sides of it an end-segment, wherein the corresponding end-segment is connected to the mid-segment by means of a linear distraction element and wherein each end-segment provides fixation parts, and wherein the second distractor module is related to a frontal bone segment to be moved, guiding the same and having fixation parts.