Patents by Inventor Thomas Brumby

Thomas Brumby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090297454
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
    Type: Application
    Filed: May 20, 2009
    Publication date: December 3, 2009
    Inventors: Heiko SCHIRMER, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Patent number: 7618957
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: November 17, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Heiko Schirmer, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Patent number: 7598260
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: October 6, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • Publication number: 20090191129
    Abstract: This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
    Type: Application
    Filed: October 23, 2008
    Publication date: July 30, 2009
    Inventors: Lutz LEHMANN, Andrea Thiele, Tobias Heinrich, Thomas Brumby, Christer Halldin, Balazs Gulyas, Sangram Nag
  • Publication number: 20090022664
    Abstract: The present invention relates to novel compounds suitable for or already radiolabelled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging.
    Type: Application
    Filed: September 7, 2007
    Publication date: January 22, 2009
    Inventors: Ananth Srinivasan, Thomas Brumby, Timo Stellfeld, Keith Graham, Ulrike Voigtmann, Jessica Becaud, Linjing Mu
  • Publication number: 20080292548
    Abstract: The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.
    Type: Application
    Filed: September 7, 2007
    Publication date: November 27, 2008
    Inventors: Lutz Lehmann, Ananth Srinivasan, Thomas Brumby, Detlef Suelzle, Timo Stellfeld, Keith Graham, Mylene Karramkam, Simon Ametamey
  • Publication number: 20080039447
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Application
    Filed: June 26, 2007
    Publication date: February 14, 2008
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schafer, Gerhard Siemeister, Ulrich Lucking, Christoph Huwe
  • Patent number: 7291624
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: November 6, 2007
    Assignee: Bayer Schering Pharma AG
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • Publication number: 20070189969
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
    Type: Application
    Filed: July 17, 2006
    Publication date: August 16, 2007
    Inventors: Heiko Schirmer, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Patent number: 7235561
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: June 26, 2007
    Assignee: Schering AG
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • Publication number: 20070020183
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with an N-alkyl group of general formula 1, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 25, 2007
    Inventors: Heiko Schirmer, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Publication number: 20070003484
    Abstract: The invention relates to hydroxypyridinone derivatives, their metal complexes, their preparation and their use for preparing conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
    Type: Application
    Filed: December 20, 2005
    Publication date: January 4, 2007
    Inventors: Heribert Schmitt-Willich, Heiko Schirmer, Johannes Platzek, Stephane Dumas, Vincent Jacques, Thomas Brumby, Detlev Suelzle, Bernd Misselwitz
  • Publication number: 20060292079
    Abstract: The invention relates to conjugates of hydroxypyridinone derivative metal complexes and to their preparation. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
    Type: Application
    Filed: December 20, 2005
    Publication date: December 28, 2006
    Inventors: Heribert Schmitt-Willich, Heiko Schirmer, Johannes Platzek, Stephane Dumas, Vincent Jacques, Thomas Brumby, Detlev Suelzle, Bernd Misselwitz
  • Publication number: 20040224966
    Abstract: This invention relates to pyrimidine derivatives of general formula I 1
    Type: Application
    Filed: May 11, 2004
    Publication date: November 11, 2004
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schafer, Gerhard Siemeister, Ulrich Lucking, Christoph Huwe
  • Publication number: 20040208828
    Abstract: Enantiomer-pure compounds of general formulas VIIa and VIIb 1
    Type: Application
    Filed: February 4, 2004
    Publication date: October 21, 2004
    Inventors: Lutz Lehmann, Matthias Friebe, Thomas Brumby, Detlev Suelzle, Johannes Platzek
  • Publication number: 20040102630
    Abstract: This invention relates to pyrimidine derivatives of general formula I 1
    Type: Application
    Filed: November 7, 2002
    Publication date: May 27, 2004
    Applicant: Schering AG
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schafer, Gerhard Siemeister, Ulrich Lucking, Christoph Huwe
  • Patent number: 6284779
    Abstract: The invention relates to the compounds of Formula I as well as the process for their production and their use as pharmaceutical agents.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: September 4, 2001
    Assignees: Schering Aktiiengesellschaft, Vertex Pharmaceuticals Incorporated
    Inventors: Thomas Brumby, Fiona McDonald, Eckhard Ottow, Herbert Schneider
  • Patent number: 5616573
    Abstract: Glucocorticoids of general formula IR--Val--O--GC (II),are described,in whichO-GC is the radical of a 21-hydroxycorticoid that has an antiinflammatory action,Val represents a valine radical in the 21-position of the corticoid andR means a hydrogen atom or a hydrocarbon radical with up to 32 carbon atoms that is optionally substituted by hydroxy groups, amino groups, oxo groups and/or halogen atoms and/or interrupted by oxygen atoms, SO.sub.2 groups and/or NH groups and their salts.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: April 1, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Hans J. Zentel, Michael Topert, Henry Laurent, Thomas Brumby, Peter Esperling
  • Patent number: 5547958
    Abstract: 8.alpha.-acylamino ergolines are useful dopamine agonists.
    Type: Grant
    Filed: December 27, 1994
    Date of Patent: August 20, 1996
    Assignee: Schering Aktiengesellschaft
    Inventors: Gerhard Sauer, Thomas Brumby, Helmut Wachtel, Jonathan Turner, Peter-Andreas Loschmann
  • Patent number: 5527777
    Abstract: The invention concerns LHRH antagonists of the general formula (I),X-X.sub.1 -X.sub.2 -X.sub.3 -L-Ser-L-Tyr-X.sub.6 -L-Leu-X.sub.8 -L-Pro-X.sub.10 (I)The invention concerns LHRH antagonists of the general formula (I), in which X is an acyl group, X.sub.1 is a D-Nal, X.sub.2 is D-(4-Cl)-Phe, X.sub.3 is D-(3)-Pal, X.sub.6 is D-Cit or D-Neu, X.sub.8 is L-Arg or L-Neu, at least one of the groups X.sub.6 and X.sub.8 being a Neu, and X.sub.10 is D-Ala-NH.sub.2, Neu being a group of formula (II), (IV), (IX) or (X), wherein W is one of the group (a)-(d). The invention includes drugs containing a compound of formula (I), plus the usual auxiliaries and carriers. These drugs are suitable for use in cases of carcinoma of the prostate and in endometriosis, as well as for fertility control.
    Type: Grant
    Filed: May 4, 1994
    Date of Patent: June 18, 1996
    Assignee: Schering Aktiengesellschaft
    Inventors: Paul Thamm, Alessandro Lobbia, Thomas Brumby, Johann Mulzer, Fridtjog Schroder, Ursula Habenicht