Abstract: The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of the coating as measured by the water contact angle is below 90°, and the long term static friction forces between the first and the second component are below 14 N. The coatings according to the present invention are especially suited for permanently coating in ternal surfaces of containers equipped with stoppers for storage and administration of liquid protein preparations, such as insulin preparations. The coating is preferably a silicon-containing coating, such as a poly(dialkyl siloxane) oil or copolymer.

Abstract: The present invention relates to a coating system, in particular to a coating system for articles where plastic materials slide against flexible rubber materials. The coating system is a silicone oil based coating having a viscosity of at least 200,000 centistokes, i.e. a high viscosity coating. The coating comprises in a preferred embodiment a silicone oil based block or graft copolymer, or segmented copolymer. Further the invention relates to a process of producing a component of an article coated as described above, comprising adding the coating material to the component material prior to molding and subsequently molding the component from the mixture, or molding the component from the component material and subsequently applying the coating material to the at least one surface of the component, as well as an article coated with a silicone oil based coating as defined above. Such an article is preferably a medical article, such as a container or an injection cylinder and a stopper.

Abstract: A cylinder ampoule (1) having a first end sealed by a closure through which an injection unit can communicate with a medicament in the ampoule and a second end closed by a piston (3) which can be forced into the ampoule (1) to press out a dose of a medicament stored in the ampoule between the closure and the piston (3) through said injection unit, which cylinder ampoule (1) has a non-circular inner cross section and which piston (3) has a non-circular cross section corresponding to the inner cross section of the ampoule (1). A piston rod (4) has a pressure foot (5) which has a cross section corresponding to the inner cross section of the ampoule (1) and is non-rotatably connected to the piston rod (4).

Abstract: In an ampoule for a medicament the space accommodating the medicament is defined by an ampoule wall (1) a pierceable seal (5) closing one end of the ampoule and a piston (7) closing the other end of the ampoule. A metal containing fixation element (8) is secured to one of the parts defining the medicament accommodating space. A mixing element (9, 10) also containing a metal and having a density larger than 1,0 g/cm.sup.3 is movable in medicament accommodating space. At least one of the elements, the fixation element (8) and the mixing element (9, 10), can be attracted by a magnet, and at least one of these elements is a magnetic element, the magnetic strength being so that the mixing element (9, 10) can during normal handling of the ampoule be fixed relative to this ampoule by the magnetic attraction between the fixation element (8) and the mixing element (9, 10) but may be released from its fixed position by manual operation.

Abstract: The present invention relates to a drug delivery system, comprising a reservoir from which set doses are apportioned, a dose setting mechanism by which the relative position of two elements is changed by a distance proportional to a set dose, and a push button by activation of which an element is moved a distance corresponding to the distance proportional to the set dose, further comprises a working cylinder having an open end into which a plunger fits, and a closed end at which an inlet and an outlet port connect the space beneath the plunger with an inlet communicating with the reservoir and an outlet communicating with a drug delivery member, respectively. Valves means at the inlet and outlet control the passages from the reservoir to the working cylinder and from the working cylinder to the drug delivery member, respectively. The cylinder with the plunger, and the injection member are independently exchangeable, disposable parts.

Abstract: A medicaments, container for storing a liquid medicament comprising one or more active medicaments, water and at least one preservative has a preferably cylindrical wall defining an interior space for such liquid medicament. The wall includes at least two opposed portions composed of a polymer material with a thickness of between 0.3 mm and 3 mm, a light transmission at 400 nm of 25% or more measured through the opposed container wall portions when the container is filled with water, using a standard spectrophotometer and air as reference. The polymer wall portions are of a material comprising at least 70% by weight of a linear optionally branched polyolefin material, the olefin monomer being selected from ethylene, propylene, butylene or a mixture thereof The polyolefin material has a crystallinity above 35% by weight, measured by differential scanning calorimetry, by cutting pieces from the container walls and heating them in an aluminum pan from 10.degree. C. to 270.degree. C. at the scanning rate of 10.