Abstract: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).

Abstract: The invention relates to methods for obtaining a protein conjugate wherein a cysteine residue of the protein serves as attachment point for the chemical moiety conjugated to the protein.

Abstract: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).

Abstract: A rotor of an electric machine has a circumferential surface and a permanent-magnet structure on the circumferential surface . A contour of the permanent-magnet structure has a stepped section with several steps, whereby each step has a first extension that is oriented essentially perpendicularly to the circumferential direction of the circumferential surface as well as a second extension that is oriented parallel to the circumferential direction and that connects the first extension to a first extension of an adjacent step. The first extension of a first step differs from the first extension of a second step that is adjacent to the first step and/or the second extension of a first step differs from the second extension of the second step.

Abstract: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).

Abstract: A rotor of an electric machine has a circumferential surface and a permanent-magnet structure on the circumferential surface. A contour of the permanent-magnet structure has a stepped section with several steps, whereby each step has a first extension that is oriented essentially perpendicularly to the circumferential direction of the circumferential surface as well as a second extension that is oriented parallel to the circumferential direction and that connects the first extension to a first extension of an adjacent step. The first extension of a first step differs from the first extension of a second step that is adjacent to the first step, and/or the second extension of a first step differs from the second extension of the second step.

Abstract: Described are methods for determination of peptide specific parameter(s) of a mixture comprising a target peptide and a related impurity (or impurities) to be used in a simulation model of chromatographic separation using mathematical model(s). Also described are chromatographic simulation methods using above determined parameters, as well as computer systems and computer programs for performing one or more of the above method(s).

Abstract: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).

Abstract: The invention relates to methods for obtaining a protein conjugate wherein a cysteine residue of the protein serves as attachment point for the chemical moiety conjugated to the protein.

Abstract: The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.

Abstract: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).

Abstract: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).

Abstract: The aim of the invention is to provide a cost-effective, easily regulated rotary-linear drive. Therefore, the invention provides for the rotary-linear drive to connect a rotary drive (10) to a linear drive module (11). The linear drive module (11) comprises a rotatable drive-side receiving device for receiving a torque from the rotary drive (10). Additionally, the linear drive module has a linear motor, the armature (15) of which is rotatable, is rotated by a stator (14), and comprises an output element for the purpose of driving the shaft (12) in a rotary-linear fashion. To this end, the linear drive module (11) also comprises a coupling device (16) that couples the receiving device and the armature (15) in a rotationally secure but not linear fashion.

Abstract: The invention relates to an effective process for purifying a peptide which has been prepared by solid phase peptide synthesis. Also encompassed by the invention is a kit comprising reagents for said process and the purified peptide obtained by said process.

Abstract: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).

Abstract: The invention relates to more accurate rotative and linear positional measurement for a rotary-linear drive. A measuring system comprising a linear sensor (12) and a rotary sensor (20) is disclosed. A decoupling unit (11,14,17) decouples the rotary displacement from the linear displacement of a shaft (10). The decoupling unit (11,14,17) has either a first measuring section (11), which is coupled in a fixed manner to the shaft to be measured (10) and tapped by the linear sensor (12) and a second measuring section (17), which is exclusively non-rotatably coupled to the shaft to be measured (10) and is tapped by the rotary sensor (20), or a first measuring section, which is coupled in a fixed manner exclusively linearly to the shaft to be measured and is tapped by the linear sensor and a second measuring section, which is non-rotatably coupled to the shaft to be measured and is tapped by the rotary sensor.

Abstract: A plastics injection-molding machine is to be equipped with a more compact drive that undergoes less wear. For this purpose, it is envisaged to integrate the direct rotational drive into the direct linear drive. Accordingly, the electric linear motor has a pot-shaped external rotor (13), in the inner space of which the main part of a hollow-cylindrical stator (16) of the linear motor is arranged and which is firmly connected to the output shaft (10). The rotary drive has a stator (18), which is mounted on the inner wall of the hollow-cylindrical stator (16) of the linear motor, and a rotor, which is firmly coupled to the output shaft (10) within the stator (18) of the rotary electric motor. This direct drive produces a very compact type of construction and it is possible to dispense with easily wearing threaded spindles.

Abstract: The invention concerns a method for the industrial production of antibodies.

Abstract: The aim of the invention is to provide a cost-effective, easily regulated rotary-linear drive. Therefore, the invention provides for the rotary-linear drive to connect a rotary drive (10) to a linear drive module (11). The linear drive module (11) comprises a rotatable drive-side receiving device for receiving a torque from the rotary drive (10). Additionally, the linear drive module has a linear motor, the armature (15) of which is rotatable, is rotated by a stator (14), and comprises an output element for the purpose of driving the shaft (12) in a rotary-linear fashion. To this end, the linear drive module (11) also comprises a coupling device (16) that couples the receiving device and the armature (15) in a rotationally secure but not linear fashion.

Abstract: The driving force produced by the linear drive on a motor with a rotational drive and with a linear drive can be registered in a quantified fashion by virtue of the fact that deformation of a motor element (top disc 22) which connects a rotor (30) of the linear drive to an output shaft (24) is measured. A corresponding signal can then be assigned to a measured value for the axial force, either on the basis of a known linear relationship or on the basis of standardization. Strain measuring gauges (DMS1 to DMS4) are used to measure the deformation.