Abstract: A system, computer program product and method of processing function calls in a distributed application environment are provided. A number of function calls for communication from a sending application to a receiving application are queued in a database. Dependencies among at least a portion of the function calls that are being queued are determined while the function calls are stored in the queues. A schedule of execution of the function calls is then generated based on the determined dependencies.

Abstract: Disclosed are compositions and methods for inhibiting hexokinase enzymes in mammalian cells. Specifically provided are proteins that stimulate the production of trehalose-6-phosphate and their respective genes; hexokinase-specific ribozymes and genes encoding such constructs; and agents that competitively reduce hexokinase activity, e.g., by displacing hexokinase from mitochondria, and their respective genes. The latter group of agents includes inactive hexokinases and fragments thereof that retain mitochondrial binding functions and hexokinase-glucokinase chimeras that further substitute glucokinase activity for hexokinase activity. Mammalian cells including such hexokinase inhibitors, methods of making such cells and various in vitro and in vivo methods of using cells with reduced hexokinase activity are also described herein.