Patents by Inventor Thomas C. Bruice

Thomas C. Bruice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying, obtaining and using new polyketide compounds
    Publication number: 20030045710
    Abstract: The invention provides novel polyketide compounds having desired bioactivity, including neuroregenerative activity without immunosuppressive activity, and methods of making and using these compounds.
    Type: Application
    Filed: March 15, 2002
    Publication date: March 6, 2003
    Inventors: Thomas C. Bruice, Helgi Adalsteinsson, Kalju Kahn
  • Deoxynucleic alkyl thiourea compounds and uses thereof
    Patent number: 6169176
    Abstract: The invention provides novel deoxynucleic alkyl thiourea (dNXt) oligonucleotide compounds for use in antisense or antigene therapy.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: January 2, 2001
    Assignee: The Regents of the University of California
    Inventors: Thomas C. Bruice, Arya P. Dev
  • Deoxynucleic alkyl and alkoxy thiourea compounds
    Patent number: 6136965
    Abstract: The invention provides novel deoxynucleic alkyl thiourea (dNXt) oligonucleotide compounds for use in antisense or antigene therapy.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: October 24, 2000
    Assignee: The Regents of the University of California
    Inventors: Thomas C. Bruice, Dev P. Arya
  • Polynucleoside chain having multiple ribonucleosides, the nucleosides coupled by guanidyl linkages
    Patent number: 6013785
    Abstract: The invention provides a cationic polynucleoside chain having multiple nucleosides, the nucleosides being coupled together by positively charged guanidyl linkages.
    Type: Grant
    Filed: January 5, 1996
    Date of Patent: January 11, 2000
    Assignee: The Regents of The University of California
    Inventors: Thomas C. Bruice, Robert O. Dempcy, Orn Almarsson
  • Triheterocyclic peptides capable of binding the minor and major grooves of DNA
    Patent number: 5698674
    Abstract: The present invention provides a triheterocyclic peptide having first, second, and third 5-member heterocyclic moieties having the following formula CR.sub.3 CONH--Q.sup.1 --CONH--Q.sup.2 --CONH--Q.sup.3 -CONH--(CR.sub.3).sub.S --B, wherein Q.sup.1 is selected from a group consisting of: ##STR1## wherein Q.sup.2 is selected from a group consisting of: ##STR2## wherein Q.sup.3 is selected from a group consisting of: ##STR3## wherein at least one of A and Z is other than C; wherein A is C, N, O, or S; wherein B is N(CR.sub.3).sub.n or C(NH.sub.2).sub.2 ; wherein n is an integer from 2 to 10; wherein P is H, a lower alkyl or a halogen; wherein Q1, Q2, and Q3 are the same or different; wherein R is H, a lower alkyl group; wherein S is an integer from 1 to 10; wherein X' represents CR.sub.3, (CR.sub.2).sub.n --NRY, or (CR.sub.2).sub.n --CR.sub.2 Y; wherein X" represents CR.sub.3, (CR.sub.2).sub.n --NRY, or (CR.sub.2).sub.n --CR.sub.2 Y; wherein X'" represents CR.sub.3, (CR.sub.2).sub.n --NRY, or (CR.sub.2).sub.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: December 16, 1997
    Assignee: The Regents of the University of California
    Inventors: Thomas C. Bruice, Kenneth A. Browne, Gong-Xin He
  • Polynucleoside chain with 3'.fwdarw.5' guanidyl linkages
    Patent number: 5696253
    Abstract: The invention provides a cationic polynucleoside chain having multiple nucleosides, the nucleosides being coupled together by positively charged guanidyl linkages.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: December 9, 1997
    Assignee: The Regents of the University of California
    Inventors: Thomas C. Bruice, Robert O. Dempcy, Orn Almarsson
  • Synthetic drug molecules that mimic metalloenzymes
    Patent number: 5217966
    Abstract: Synthetic enzymes that mimic the catalytic activity of naturally occurring enzymes by providing catalytic sites enclosed in cages that protect the sites from undesirable molecules and attract and permit entry of the relevant substrates are disclosed. Molecules that mimics the catalytic activity of superoxide dismutase and catalase, pharmaceutical compositions containing these molecules, and methods for using these compositions are also disclosed.
    Type: Grant
    Filed: January 17, 1992
    Date of Patent: June 8, 1993
    Assignee: The Regents of the University of California
    Inventor: Thomas C. Bruice
  • Synthetic drug molecules that mimic metalloenzymes
    Patent number: 5202317
    Abstract: Synthetic enzymes that mimic the catalytic activity of naturally occurring enzymes by providing catalytic sites enclosed in cages that protect the sites from undesirable molecules and attract and permit entry of the relevant substrates are disclosed. Molecules that mimics the catalytic activity of superoxide dismutase and catalase, pharmaceutical compositions containing these molecules, and methods for using these compositions are also disclosed.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: April 13, 1993
    Assignee: The Regents of the University of California
    Inventor: Thomas C. Bruice