Patents by Inventor Thomas C. Condamine

Thomas C. Condamine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR MONITORING POLYMORPHONUCLEAR MYELOID DERIVED SUPPRESSOR CELLS
    Publication number: 20210318310
    Abstract: A method of obtaining a population of cells enriched in human polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs) comprises isolating from a cell suspension those cells which express LOX-1 to provide a population of cells enriched with PMN-MDSCs. A method of monitoring the population of LOX-1+ cells in a cell-containing biological sample is useful for determining the efficacy of treatment or the metastasis or increasing progression of cancer. Other cell isolation and diagnostic methods are also described.
    Type: Application
    Filed: June 24, 2021
    Publication date: October 14, 2021
    Inventors: Dmitry I. Gabrilovich, Thomas C. Condamine
  • Methods for monitoring polymorphonuclear myeloid derived suppressor cells
    Patent number: 11073521
    Abstract: A method of obtaining a population of cells enriched in human polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs) comprises isolating from a cell suspension those cells which express LOX-1 to provide a population of cells enriched with PMN-MDSCs. A method of monitoring the population of LOX-1+ cells in a cell-containing biological sample is useful for determining the efficacy of treatment or the metastasis or increasing progression of cancer. Other cell isolation and diagnostic methods are also described.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: July 27, 2021
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Dmitry I. Gabrilovich, Thomas C. Condamine
  • Methods for Monitoring Polymorphonuclear Myeloid Derived Suppressor Cells and Compositions and Methods of Treatment of Cancer
    Publication number: 20210148916
    Abstract: A method of obtaining a population of cells enriched in human polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs) comprises isolating from a cell suspension those cells which express LOX-1 to provide a population of cells enriched with PMN-MDSCs. A method of monitoring the population of LOX-1+ cells in a cell-containing biological sample is useful for determining the efficacy of treatment or the metastasis or increasing progression of cancer. Other cell isolation and diagnostic methods are also described. A composition for use in diagnosing and treating cancer related to PMN-MDSC is provided that contains antagonists and/or inhibitors of genes related to the ER stress response.
    Type: Application
    Filed: July 30, 2020
    Publication date: May 20, 2021
    Inventors: Dmitry I. Gabrilovich, Thomas C. Condamine
  • METHODS FOR MONITORING POLYMORPHONUCLEAR MYELOID DERIVED SUPPRESSOR CELLS
    Publication number: 20180164313
    Abstract: A method of obtaining a population of cells enriched in human polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs) comprises isolating from a cell suspension those cells which express LOX-1 to provide a population of cells enriched with PMN-MDSCs. A method of monitoring the population of LOX-1+ cells in a cell-containing biological sample is useful for determining the efficacy of treatment or the metastasis or increasing progression of cancer. Other cell isolation and diagnostic methods are also described.
    Type: Application
    Filed: May 31, 2016
    Publication date: June 14, 2018
    Inventors: Dmitry I. Gabrilovich, Thomas C. Condamine
  • METHODS FOR MONITORING POLYMORPHONUCLEAR MYELOID DERIVED SUPPRESSOR CELLS, AND COMPOSITIONS AND METHODS OF TREATMENT OF CANCER
    Publication number: 20180059115
    Abstract: A method of obtaining a population of cells enriched in human polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs) comprises isolating from a cell suspension those cells which express LOX-1 to provide a population of cells enriched with PMN-MDSCs. A method of monitoring the population of LOX-1+ cells in a cell-containing biological sample is useful for determining the efficacy of treatment or the metastasis or increasing progression of cancer. Other cell isolation and diagnostic methods are also described. A composition for use in diagnosing and treating cancer related to PMN-MDSC is provided that contains antagonists and/or inhibitors of genes related to the ER stress response.
    Type: Application
    Filed: August 4, 2017
    Publication date: March 1, 2018
    Inventors: Dmitry I. Gabrilovich, Thomas C. Condamine