Patents by Inventor Thomas C. Crawford

Thomas C. Crawford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY
    Publication number: 20120058971
    Abstract: Methods and compositions relating to CDP-taxane conjugates are described herein.
    Type: Application
    Filed: August 12, 2011
    Publication date: March 8, 2012
    Applicant: CERULEAN PHARMA INC.
    Inventors: Thomas C. Crawford, Oliver S. Fetzer, Lawrence Alan Reiter, Marc Wolfgang
  • CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY
    Publication number: 20120004195
    Abstract: Methods and compositions relating to CDP-proteasome inhibitor conjugates are described herein.
    Type: Application
    Filed: August 12, 2011
    Publication date: January 5, 2012
    Inventors: Alexandra Glucksmann, Lawrence Alan Reiter, Thomas C. Crawford
  • POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
    Publication number: 20110268658
    Abstract: Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
    Type: Application
    Filed: January 11, 2011
    Publication date: November 3, 2011
    Inventors: Thomas C. Crawford, Scott Eliasof, Geeti Gangal, Pei-Sze Ng, Lawrence Alan Reiter
  • CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY
    Publication number: 20110237540
    Abstract: Methods and compositions relating to CDP-taxane conjugates are described herein.
    Type: Application
    Filed: November 23, 2010
    Publication date: September 29, 2011
    Inventors: Thomas C. Crawford, Oliver S. Fetzer, Lawrence Alan Reiter, Marc Wolfgang
  • POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
    Publication number: 20110189092
    Abstract: Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
    Type: Application
    Filed: September 29, 2010
    Publication date: August 4, 2011
    Inventors: Scott Eliasof, Thomas C. Crawford, Geeti Gangal, Lawrence Alan Reiter, Pei-Sze Ng
  • CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY
    Publication number: 20110178287
    Abstract: Methods and compositions relating to CDP-proteasome inhibitor conjugates are described herein.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 21, 2011
    Inventors: Alexandra Glucksmann, Lawrence Alan Reiter, Thomas C. Crawford
  • POLYMER-EPOTHILONE CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
    Publication number: 20100285144
    Abstract: Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer or neurological deficits. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
    Type: Application
    Filed: March 29, 2010
    Publication date: November 11, 2010
    Inventors: Scott Eliasof, Thomas C. Crawford, Geeti Gangal, Lawrence Alan Reiter, Pei-Sze Ng
  • POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
    Publication number: 20100247669
    Abstract: Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Inventors: Scott Eliasof, Thomas C. Crawford, Geeti Gangal, Lawrence Alan Reiter, Pei-Sze Ng
  • POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
    Publication number: 20100247668
    Abstract: Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Inventors: Scott Eliasof, Thomas C. Crawford, Geeti Gangal, Lawrence Alan Reiter, Pei-Sze Ng
  • Reactive crystallization method to improve particle size
    Patent number: 6558435
    Abstract: This invention provides a method of conducting a simultaneous chemical reaction and controlled crystallization of the product employing impinging fluid jet streams containing reactants capable of producing the product with desired particle size characteristics.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: May 6, 2003
    Assignees: Pfizer, Inc., Pfizer Products, Inc.
    Inventors: David J. Am Ende, Thomas C. Crawford, Neil P. Weston
  • Reactive crystallization method to improve particle size
    Publication number: 20020016498
    Abstract: This invention provides a method of conducting a simultaneous chemical reaction and controlled crystallization of the product employing impinging fluid jet streams containing reactants capable of producing the product with desired particle size characteristics.
    Type: Application
    Filed: May 23, 2001
    Publication date: February 7, 2002
    Inventors: David J. Am Ende, Thomas C. Crawford, Neil P. Weston
  • Battery replacement and magnetic pickup apparatus
    Patent number: 5288119
    Abstract: An apparatus for removing and replacing small batteries in electronic devices such as hearing aids or handling small magnetic parts has a housing in which a reciprocating shaft is placed having a magnet at one end. When the reciprocating shaft is placed in its extended pickup position, the magnet is brought close to the end of the housing, and into contact with the battery or other magnetic object. Once in contact with the object, the apparatus may be used for manipulation. Once the object is placed where it is to be left, the reciprocating shaft may be moved to a retracted position weakening the magnetic field holding the battery to the end of the apparatus. The reciprocating shaft is moved and locked into its extended and retracted positions with a rotating ratchet mechanism operated with a thumb of the hand that holds the apparatus. A shim in separable parts of the housing makes adjustment of the terminal end position of the magnet possible.
    Type: Grant
    Filed: October 22, 1992
    Date of Patent: February 22, 1994
    Inventors: Thomas C. Crawford, Jr., William T. Jones, Jr.
  • Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
    Patent number: 5118703
    Abstract: Certain enol ethers and esters of the formula ##STR1## where X and Y are each hydrogen, fluoro or chloro; R.sup.1 is 2-thienyl or benzyl and R is alkanoyl, cycloalkylcarbonyl, phenylalkanoyl, chlorobenzoyl, methoxybenzyl, phenyl, thenoyl, omega-alkoxycarbonylalkanoyl, alkoxycarbonyl, phenoxycarbonyl, 1-alkoxyalkyl, 1-alkoxycarbonyloxyalkyl, alkyl, alkylsulfonyl, methylphenylsulfonyl or dialkylphosphonate are useful as prodrug forms the known 3-acyl-2-oxindole-1-carboxamide antiinflammatory and analgesic agents.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: June 2, 1992
    Assignee: Pfizer Inc.
    Inventors: Lawrence A. Reiter, Thomas C. Crawford
  • Antiinflammatory compositions and methods
    Patent number: 4994457
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as piroxicam, or a pharmaceutically acceptable salt thereof, with 5'-guanylic acid or N-acetyl-L-methionine, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 19, 1987
    Date of Patent: February 19, 1991
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, David L. Larson, Joseph G. Lombardino
  • Antinflammatory compositions and methods
    Patent number: 4874757
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.
    Type: Grant
    Filed: November 4, 1988
    Date of Patent: October 17, 1989
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Antiinflammatory compositions and methods
    Patent number: 4812455
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilzer diazepam, or antihypertensive trimazosin.
    Type: Grant
    Filed: April 11, 1988
    Date of Patent: March 14, 1989
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Antiinflammatory compositions and methods
    Patent number: 4766117
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.
    Type: Grant
    Filed: December 12, 1986
    Date of Patent: August 23, 1988
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Antiinflammatory compositions and methods
    Patent number: 4672061
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesis acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.
    Type: Grant
    Filed: January 21, 1986
    Date of Patent: June 9, 1987
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Process for making 2-oxindole-1-carboxamides and intermediates therefor
    Patent number: 4665194
    Abstract: Preparation of 2-oxindole-1-carboxamides by reaction of 2-oxindoles with chlorosulfonyl isocyanate to produce novel N-chlorosulfonyl-2-oxindole-1-carboxamides which are then hydrolyzed to 2-oxindole-1-carboxamides useful as intermediates for analgesic and antiinflammatory agents.
    Type: Grant
    Filed: July 12, 1985
    Date of Patent: May 12, 1987
    Assignee: Pfizer Inc.
    Inventor: Thomas C. Crawford
  • Battery handling tool
    Patent number: D350471
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: September 13, 1994
    Inventors: Thomas C. Crawford, Jr., William T. Jones, Jr.