Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: The present disclosure generally relates to a scrub head capable of use in a disposable toilet bowl cleaning system and to methods of making and using the scrub head. The present disclosure also generally relates to a disposable toilet bowl cleaning system and to methods of making and using the disposable toilet bowl cleaning system.

Abstract: Spindles (10) adapted to receive a tape roll having a core opening thereof and comprising an elongate body (12) and at least one spacing member (14a, 14b, 14c) comprising a protuberance (18a, 18b, 18c) wherein the protuberance is configured such that it can be configured in a first protruding position and in a second non-protruding position. Also, dispensers comprising such spindles, methods of assembling such dispensers, and methods of dispensing tape from tape rolls mounted on such spindle.

Abstract: The disclosed corner caddy can hold an item in the corner body, but also includes a corner region that is substantially open and free of the caddy body that is useful for hanging or holding large or long items efficiently. In one embodiment, the corner caddy comprises a caddy body, a first attachment wall, a second attachment wall, and a corner region. The base comprises a first end, a second end, a front surface, and a rear surface. The first attachment wall is adjacent the first end and external to the caddy body, and defines a first plane. The second attachment wall is adjacent the second end and external to the caddy body, and defines a second plane. The first plane and second plane intersect to form a corner region, which is adjacent the rear surface and is substantially open and free of the caddy body.

Abstract: The disclosure relates to a dispenser assembly comprising a bin with a spring actuated shuttle for engaging with a plurality of individual dispensable units contained within a refill package. The disclosed dispenser assembly provides easy dispensing of individual dispensable units from a bin. The individual dispensable units are contained within a refill package for easy reloading. In one embodiment, a tool is used to remove an individual dispensable unit and therefore the dispensing is achieved without touching the individual dispensable unit with the user's hands.

Abstract: Spindles (10) adapted to receive a tape roll having a core opening thereof and comprising an elongate body (12) and at least one spacing member (14a, 14b, 14c) comprising a protuberance (18a, 18b, 18c) wherein the protuberance is configured such that it can be configured in a first protruding position and in a second non-protruding position. Also, dispensers comprising such spindles, methods of assembling such dispensers, and methods of dispensing tape from tape rolls mounted on such spindle.

Abstract: A behind-the-head mounted personal audio set that has a first earphone portion pivotally secured to a behind-the-head headband at a first pivot which is positioned below the longitudinal centerline of the headband. In disclosed embodiments the earphone is also slidably secured to the headband thereby allowing additional adjustment to optimize wearer comfort.

Abstract: A snow sled comprising a seating portion that includes a lightweight space frame having a suspension-type seat stretched among the space frame. The sled further includes a steering portion and articulated steering mechanism that links the steering portion to the seating portion. The articulated steering mechanism allows the steering portion to be pivoted laterally relative to the seating portion so as to make the sled readily steerable. A pair of rear skis are removably attachable to the seating portion. The steering portion includes a ski support and a pair of front skis pivotably attached to the ski support. Chatter and movement of the front skis are dampened by a pair of boots that engage the ski support and the respective front skis.

Abstract: A snow sled (100) comprising a seating portion (116) that includes a lightweight space frame (104) having a suspension-type seat (108) stretched among the space frame. The sled further includes a steering portion (120) and an articulated steering mechanism (112) that links the steering portion to the seating portion. The articulated steering mechanism allows the steering portion to be pivoted laterally relative to the seating portion so as to make the sled readily steerable. A pair of rear skis (164, 168) are removably attachable to the seating portion. The steering portion (120) includes a ski support (200) and a pair of front skis (204) pivotably attached to the ski support. Chatter and movement of the front skis are dampened by a pair of boots (228) that engage the ski support and the respective front skis.