Patents by Inventor Thomas C. Nelson

Thomas C. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides encoding human SLAP-2 variant, hSLAP-2v3
    Patent number: 7811787
    Abstract: The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further relates to the use of these novel hSLAP-2v3 and hSLAP-2v4 polynucleotides and their encoded polypeptides as targets for therapeutic intervention in immunological and inflammatory disorders, autoimmune diseases, pulmonary diseases, proliferative immune disorders, and cancer.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: October 12, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Donald G. Jackson, Stanley R. Krystek, Jr., Donna A. Bassolino, Rolf-Peter Ryseck, Thomas C. Nelson, Gena S. Whitney
  • Method of diagnosing lung cancer using BGS42
    Patent number: 7741025
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: June 22, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Shujian Wu, Thomas C. Nelson, Liana M. Lee
  • Methods of diagnosing colon adenocarcinoma using mRNA encoding the human g-protein coupled receptor, HGPRBMY23
    Patent number: 7713699
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: May 11, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Thomas C. Nelson, Chandra S. Ramanathan, Rolf-Peter Ryseck, Michael G. Kornacker
  • Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23
    Patent number: 7312086
    Abstract: The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: December 25, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Thomas C. Nelson, Chandra S. Ramanathan, Rolf-Peter Ryseck, Michael G. Neubauer
  • Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42
    Patent number: 7309779
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: December 18, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Shujian Wu, Thomas C. Nelson, Liana M. Lee
  • Method of diagnosing testicular tumors using polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42
    Patent number: 7273706
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: September 25, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Shujian Wu, Thomas C. Nelson, Liana M. Lee
  • Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof
    Patent number: 7259002
    Abstract: The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing MGAT3 polypeptides, fragments, and homologues thereof. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: August 21, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Thomas C. Nelson, Jian Chen, Rupalie Meegalla, Michael Ramaker, Dong Cheng
  • Polynucleotides encoding novel cysteine proteases of the calpain superfamily, CAN-12v1 and CAN-12v2.
    Patent number: 7186564
    Abstract: The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: March 6, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jian Chen, Thomas C. Nelson, Roy J. Vaz, Franck Duclos
  • Polynucleotides encoding the novel human phosphatase, RET31, and variants thereof
    Patent number: 7153678
    Abstract: The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: December 26, 2006
    Assignee: Bristol-Myers Squibb
    Inventors: Donald G. Jackson, Chandra S. Ramanathan, John N. Feder, Liana Lee, Thomas C. Nelson, Nathan Siemers, Suzanne J. Suchard, Joshua Finger, C. Gordon Todderud, Dana Banas
  • Testis-specific tubulin tyrosine-ligase-like protein, BGS42
    Patent number: 7122358
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: October 17, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Thomas C. Nelson, Shujian Wu
  • Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42
    Patent number: 7115402
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: October 3, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John N. Feder, Shujian Wu, Thomas C. Nelson
  • Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof
    Publication number: 20040223959
    Abstract: The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: January 21, 2004
    Publication date: November 11, 2004
    Inventors: John N. Feder, Thomas C. Nelson, Jian Chen, Rupalie Meegalla, Michael Ramaker, Dong Cheng
  • Novel human G-protein coupled receptor, HGPRBMY8, expressed highly in brain
    Publication number: 20040214317
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Application
    Filed: November 13, 2003
    Publication date: October 28, 2004
    Inventors: Peter Battaglino, John N. Feder, Gabriel Mintier, Thomas C. Nelson, Chandra S. Ramanathan, Ryan Westphal, Angela M. Cacace, Lauren E. Barber, Donald R. Hawken, Michael G. Kornacker
  • Polynucleotides encoding a novel human phosphatase, BMY_HPP13
    Publication number: 20040204576
    Abstract: The present invention provides novel polynucleotides encoding a human phosphatase polypeptide, BMY_HPP13, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptide. The invention further relates to diagnostic and therapeutic methods for applying this novel human phosphatase polypeptide to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: July 2, 2003
    Publication date: October 14, 2004
    Inventors: Donald Jackson, Gary L. Schieven, Stanley R. Krystek, John N. Feder, Thomas C. Nelson, Donna A. Bassolino
  • Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42
    Publication number: 20040171131
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 7, 2003
    Publication date: September 2, 2004
    Inventors: John N. Feder, Thomas C. Nelson, Shujian Wu, Stanley R. Krystek
  • Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42
    Publication number: 20040157234
    Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: July 9, 2003
    Publication date: August 12, 2004
    Inventors: John N. Feder, Shujian Wu, Thomas C. Nelson
  • Novel human G-protein coupled receptor, HGPRBMY4, and methods of use thereof
    Publication number: 20040121330
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and polypeptide of the present invention. Methods for treating, diagnosing, preventing, and screening for neurological, cardiovascular, and prostate-, colon-, breast-, or lung-related conditions or disorders are described.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: John N. Feder, Gabriel A. Mintier, Chandra S. Ramanathan, Donald R. Hawken, Angela Cacace, Lauren E. Barber, Michael G. Kornacker, Rolf-Peter Ryseck, Kelly L. Bennett, Thomas C. Nelson
  • Novel metalloprotease polypeptide, MP-1
    Publication number: 20040048302
    Abstract: The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 11, 2004
    Inventors: Jian Chen, John N. Feder, Thomas C. Nelson, Stanley R. Krystek, Franck Duclos
  • Polynucleotides encoding a novel metalloprotease, MP-1
    Publication number: 20040043407
    Abstract: The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: August 27, 2003
    Publication date: March 4, 2004
    Inventors: Jian Chen, John N. Feder, Thomas C. Nelson, Stanley R. Krystek, Franck Duclos
  • Collapsible golf tee
    Patent number: D771207
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: November 8, 2016
    Inventors: Steven C. Nelson, Thomas C. Nelson