Patents by Inventor Thomas C. Nugent

Thomas C. Nugent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
    Patent number: 6911544
    Abstract: The present invention is directed to a process for preparing (S,S)-cis-2-phenyl-3-aminopiperidine and (S,S)-cis-2-phenyl-3-tertbutoxycarbonylaminopiperidine.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: June 28, 2005
    Assignees: Pfizer Inc., DSM Pharmaceuticals, Inc.
    Inventors: Robert Seemayer, Thomas C. Nugent, Jack Liang
  • Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
    Patent number: 6861526
    Abstract: A process for preparing (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine. The process includes the steps of contacting a compound containing a mixture of R- and S-isomers and having the formula with an effective amount of a chiral organic acid in the presence of an organic solvent and an effective amount of an organic carboxylic acid for converting the R-isomer into an acid salt of the S isomer, wherein the organic solvent is capable of solubilizing the compound containing the mixture of R- and S-isomers, while precipitating the acid salt and the organic carboxylic acid is different from the chiral organic acid; neutralizing the acid salt with a base to provide an S-isomer of a chiral ketone of the formula ; and reacting the chiral ketone with an organic amine in the presence of a Lewis acid to provide the corresponding imine and reducing the imine.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: March 1, 2005
    Assignees: Pfizer Inc., DSM Pharmaceuticals, Inc.
    Inventors: Robert Seemayer, Thomas C. Nugent
  • Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
    Publication number: 20040116704
    Abstract: A process for preparing (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine.
    Type: Application
    Filed: October 6, 2003
    Publication date: June 17, 2004
    Applicants: PFIZER INC., DSM PHARMACEUTICALS, INC.
    Inventors: Robert Seemayer, Thomas C. Nugent
  • Process for the preparation of (S,S)-CIS-2-phenyl-3-aminopiperidine
    Publication number: 20040110953
    Abstract: The present invention is directed to a process for preparing (S,S)-cis-2-phenyl-3-aminopiperidine and (S,S)-cis-2-phenyl-3-tertbutoxycarbonylaminopiperidine.
    Type: Application
    Filed: October 9, 2003
    Publication date: June 10, 2004
    Applicants: PFIZER INC., DSM PHARMACEUTICALS, INC.
    Inventors: Robert Seemayer, Thomas C. Nugent, Jack Liang