Abstract: A method for systemic administration of a hydrophobic substance to a mammal is disclosed. The method involves delivering the hydrophobic substance to the dermis of the mammal whereby improved systemic absorption is obtained compared to absorption produced upon delivering the substance subcutaneously by bolus administration.

Abstract: A method for systemic administration of a hydrophobic dopamine agonist to a mammal is disclosed. The method involves delivering the hydrophobic dopamine agonist to the dermis of the mammal whereby improved systemic absorption is obtained compared to absorption produced upon delivering the substance subcutaneously by bolus administration.

Abstract: A method for administration of a substance into the dermis of a mammal is disclosed. The method involves administration into the dermis by injection which results in improved systemic absorption relative to that obtained upon subcutaneous administration of the substance. The substance administered may be a growth hormone, a low molecular weight heparin or a dopamine receptor agonist.

Abstract: A method for administration of a substance into the dermis of a mammal is disclosed. The method involves administration into the dermis by injection which results in improved systemic absorption relative to that obtained upon subcutaneous administration of the substance.

Abstract: A method for administration of a substance into the dermis of a mammal is disclosed. The method involves administration into the dermis by injection which results in improved systemic absorption relative to that obtained upon subcutaneous administration of the substance. The substance administered may be a growth hormone, a low molecular weight heparin or a dopamine receptor agonist.

Abstract: A novel packing material is provided for liquid chromatographic columns, having a maximum pore size around 80 angstroms, a hydrophobic coating on the inner surfaces adapted to absorb hydrophobic analytes, and a hydrophilic coating on the outer surfaces adapted to reject proteins in the analyte sample. A novel method is provided for making the packing material, wherein the packing base is coated, inside and out, with a hydrophilic substance, a hydrophobic substance is bonded to the hydrophilic substance, and the hydrophobic substance is selectively removed from the external surfaces by treatment with an enzyme of a size too large to penetrate into the pores.