Patents by Inventor Thomas C. Schulz

Thomas C. Schulz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for feeder-free pluripotent stem cell media containing human serum
    Patent number: 8623650
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: January 7, 2014
    Assignee: Viacyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Stem cell aggregate suspension compositions and methods of differentiation thereof
    Patent number: 8445273
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: May 21, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D Agulnick, E Edward Baetge, Kevin A D'Amour, Thomas C Schulz, Allan J Robins
  • Compositions and methods useful for culturing differentiable cells
    Patent number: 8415158
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: April 9, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Allan J Robins, Thomas C Schulz
  • Methods and compositions for feeder-free pluripotent stem cell media containing human serum
    Patent number: 8334138
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Grant
    Filed: August 15, 2010
    Date of Patent: December 18, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J Robins, Thomas C Schulz
  • COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS
    Publication number: 20120214237
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 23, 2012
    Applicant: VIACYTE, INC.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Methods for culturing pluripotent stem cells in suspension using ERBB3 ligands
    Patent number: 8211699
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: July 3, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Compositions and methods useful for culturing differentiable cells
    Patent number: 8153429
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: April 10, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • STEM CELL AGGREGATE SUSPENSION COMPOSITIONS AND METHODS OF DIFFERENTIATION THEREOF
    Publication number: 20120045830
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Application
    Filed: August 29, 2011
    Publication date: February 23, 2012
    Applicant: VIACYTE, INC.
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D. Agulnick, E. Edward Baetge, Kevin A. D'Amour, Thomas C. Schulz, Allan J. Robins
  • SMALL MOLECULES SUPPORTING PLURIPOTENT CELL GROWTH AND METHODS THEREOF
    Publication number: 20120021513
    Abstract: The present invention relates to compositions and methods for maintaining undifferentiated pluripotent stem cell cultures.
    Type: Application
    Filed: April 27, 2010
    Publication date: January 26, 2012
    Applicant: VIACYTE, INC.
    Inventors: Thomas C. Schulz, Allan J. Robins
  • Stem cell aggregate suspension compositions and methods of differentiation thereof
    Patent number: 8008075
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: August 30, 2011
    Assignee: ViaCyte, Inc.
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D. Agulnick, E. Edward Baetge, Kevin A. D'Amour, Thomas C. Schulz, Allan J. Robins
  • METHODS AND COMPOSITIONS FOR FEEDER-FREE PLURIPOTENT STEM CELL MEDIA CONTAINING HUMAN SERUM
    Publication number: 20100311164
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Application
    Filed: August 15, 2010
    Publication date: December 9, 2010
    Applicant: VIACYTE, INC.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Human Cancer Stem Cell Culture Compositions Comprising ErbB2 Variants and Methods of Use
    Publication number: 20100279399
    Abstract: The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a tumor, and for the treatment of various cancers. The invention also provides antibodies that specifically recognize the disulfide linked Erbb2?16 homodimer, an Erbb2?16/Erbb3 heterodimer, or post-translational modifications of Erbb2 that are specific to Erbb2 of variant hESCs, in addition, the invention provides a modified defined media useful in the absence of a feeder layer and in the absence of serum or serum replacement, that comprises a basal salt nutrient solution, bFGF, IGF-I, and Activin A, and wherein the composition does not comprise heregulin.
    Type: Application
    Filed: October 23, 2009
    Publication date: November 4, 2010
    Applicant: BresaGen, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Human cancer stem cell culture compositions comprising Erbb2 variants and methods of use thereof
    Patent number: 7737253
    Abstract: The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a tumor, and for the treatment of various cancers. The invention also provides antibodies that specifically recognize the disulfide linked Erbb2?16 homodimer, an Erbb2?16/Erbb3 heterodimer, or post-translational modifications of Erbb2 that are specific to Erbb2 of variant hESCs. In addition, the invention provides a modified defined media useful in the absence of a feeder layer and in the absence of serum or serum replacement, that comprises a basal salt nutrient solution, bFGF, IGF-I, and Activin A, and wherein the composition does not comprise heregulin.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: June 15, 2010
    Assignee: BresaGen, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Stem Cell Aggregate Suspension Compositions and Methods of Differentiation Thereof
    Publication number: 20100112691
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Application
    Filed: November 4, 2008
    Publication date: May 6, 2010
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D. Agulnick, E. Edward Baetge, Kevin A. D'Amour, Thomas C. Schulz, Allan J. Robins
  • Methods and Compositions for Feeder-Free Pluripotent Stem Cell Media Containing Human Serum
    Publication number: 20090104696
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Application
    Filed: October 19, 2007
    Publication date: April 23, 2009
    Inventors: Allan J. Robins, Thomas C. Schulz
  • COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS
    Publication number: 20080268534
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Application
    Filed: February 23, 2007
    Publication date: October 30, 2008
    Applicant: NOVOCELL, INC.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS
    Publication number: 20080113433
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Application
    Filed: August 13, 2007
    Publication date: May 15, 2008
    Inventors: Allan J. Robins, Thomas C. Schulz