Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: Improved design of cable tray redirector components speeds assembly and connection of cable trays. More efficiently manufactured, universal components needed throughout horizontal redirectors of a specific size and type cable tray run reduce the overall total items and cost of inventory. The improvement is in part the elimination of welding cable redirector components in favor of connecting the components with bolts and nuts in the field. The inventory and shipment of individual parts is substantially more efficient because the new components “nest” efficiently prior to assembly. Moreover, components are designed to minimize the number of bolts and nuts used without jeopardizing strength. The use of bolts and nuts to fasten the components also enables good electrical conductivity for effective electrical grounding of the assembled cable tray system.

Abstract: Vertical redirector components speed assembly and connection of cable trays. More efficiently manufactured, universal components needed throughout vertical redirectors of a specific size and type cable tray run reduce the overall total items and cost of inventory. The improvement is in part the elimination of welding cable redirector components in favor of connecting the components together with bolts and nuts in the field. The inventory and shipment of individual parts is substantially more efficient because the new components “nest” efficiently prior to assembly. Moreover, components are designed to minimize the number of bolts and nuts used without jeopardizing strength. The use of bolts and nuts to fasten the components also enables good electrical conductivity for effective electrical grounding of the assembled cable tray system.

Abstract: Improved design of cable tray redirector components speeds assembly and connection of cable trays. More efficiently manufactured, universal components needed throughout horizontal redirectors of a specific size and type cable tray run reduce the overall total items and cost of inventory. The improvement is in part the elimination of welding cable redirector components in favor of connecting the components with bolts and nuts in the field. The inventory and shipment of individual parts is substantially more efficient because the new components “nest” efficiently prior to assembly. Moreover, components are designed to minimize the number of bolts and nuts used without jeopardizing strength. The use of bolts and nuts to fasten the components also enables good electrical conductivity for effective electrical grounding of the assembled cable tray system.

Abstract: A cable guide for use with a cable tray, a method for retaining cables using a cable guide, and a kit for retaining cables containing a cable guide that includes a cable guide with a base having a top portion, a bottom portion, a first end portion, a second end portion, two side portions parallel to each other, and a longitudinal axis. The two side portions extend longitudinally in a first direction along the longitudinal axis, wherein the first end portion is opposite the second end portion in the first direction and the two side portions extend between the first end portion to the second end portion. A slot is disposed within the base, and a sidewall extends upwardly from the first end portion of the base to an upper end. A flange extends outwardly from the upper end of the sidewall and parallel to the base having a top portion, a bottom portion, a first end portion, a second end portion, a first side portion, and a second side portion opposite the first side portion.

Abstract: A cable guide is dimensioned to fit as an insert inside a cable tray. It has a bottom, two sides and a top. The top is made of interleaving, resilient flanges that are spaced apart to define a serpentine path that is wide enough to enable the user to fit a cable into the interior of the cable guide and to remove the cable through the interleaved flanges without disturbing the positional integrity of other cables in the cable tray. The cable guide may be fastened to the cable tray using one or two bolts and may be fastened so that it is spaced apart from the wall of the cable tray. Two cable guides may be installed side-by-side and several can be installed at spaced intervals along a cable tray and throughout a system.

Abstract: Improved design of cable tray redirector components speeds assembly and connection of cable trays. More efficiently manufactured, universal components needed throughout horizontal redirectors of a specific size and type cable tray run reduce the overall total items and cost of inventory. The improvement is in part the elimination of welding cable redirector components in favor of connecting the components with bolts and nuts in the field. The inventory and shipment of individual parts is substantially more efficient because the new components “nest” efficiently prior to assembly. Moreover, components are designed to minimize the number of bolts and nuts used without jeopardizing strength. The use of bolts and nuts to fasten the components also enables good electrical conductivity for effective electrical grounding of the assembled cable tray system.

Abstract: A collection of components for a cable tray system provide the components and basic hardware for assembling and installing a cable tray that can change direction in three dimensions to avoid obstacles or other cables' trays while negotiating a designated space. Components of the cable tray system may be modular, that is, pre-configured for ease of assembly, such as vertical kits and horizontal bend kits, while others are supplied in lengths for cutting them to fit jobsite requirements, such as rails and rungs. Both components provide an inherent framework that facilitates conceptualization and construction of a cable tray system at the jobsite with flexibility and simplicity to allow the present cable tray system to be employed more efficiently and accurately.

Abstract: A weld-down base conforms to a surface to support other objects, such as cables, motors, water tanks, etc. The base has at least one keyhole shaped hole, with a first portion and a second portion. On the top side of the base, the first portion of each hole is large enough to pass the head of a bolt; the second portion is only large enough to pass the shaft of the bolt but not the head. However, the second portion is stepped near the exit side to be wider so that the bolt head can be inserted into the wider first portion and then slid laterally to the second portion where the step will hold the bolt in place with its threaded shaft extending from the base. The exposed bolt allows objects such as clamps, brackets, signs, lighting, fire extinguishers, hoses, instruments, and so on, to the supporting surface.

Abstract: A cable tray connector that allows for the adjustment of cable trays attached thereto to permit adjustable, angular redirection of the cable tray path within a horizontal plane. Such connector comprises a bed having cable tray attachment zones, where the respective cable trays may be attached; side walls positioned around portions of the bed; and, optionally, a cable guide disposed centrally within the bed. Each cable tray attachment zone may include a first, circular aperture for pivotal attachment of a cable tray and at least one arcuate slotted aperture for adjustable attachment of the same cable tray.

Abstract: A cable tray connector that allows for the adjustment of cable trays attached thereto to permit adjustable, angular redirection of the cable tray path within a horizontal plane. Such connector comprises a bed having cable tray attachment zones, where the respective cable trays may be attached; side walls positioned around portions of the bed; and, optionally, a cable guide disposed centrally within the bed. Each cable tray attachment zone may include a first, circular aperture for pivotal attachment of a cable tray and at least one arcuate slotted aperture for adjustable attachment of the same cable tray.

Abstract: An adjustable cable tray joint is provided. The joint has first and second tray receptacles, each having a web and opposing walls. The first tray receptacle may further include joint flanges extending from its walls. The first and second tray receptacles are attached together by pivotal connection, the receptacles defining a rotation relative to each other about the pivotal connection. The joint flanges of the first tray receptacle are disposed proximate to the corresponding walls of the second tray receptacle. The joint includes a locking member extending through a wall of the first tray receptacle and the corresponding wall of the second tray receptacle, the locking member configured to selectively fix and release the rotation between the two tray receptacles.

Abstract: An adjustable cable tray joint is provided. The joint has first and second tray receptacles, each having a web and opposing walls. The first tray receptacle may further include joint flanges extending from its walls. The first and second tray receptacles are attached together by pivotal connection, the receptacles defining a rotation relative to each other about the pivotal connection. The joint flanges of the first tray receptacle are disposed proximate to the corresponding walls of the second tray receptacle. The joint includes a locking member extending through a wall of the first tray receptacle and the corresponding wall of the second tray receptacle, the locking member configured to selectively fix and release the rotation between the two tray receptacles.

Abstract: An implantable keratoprosthesis having a central lenticule and a peripheral annulus of corneal tissue. The keratoprosthesis includes a transparent polymeric lenticule having an elongated stem with a generally cylindrical outer surface and a central axis. On one end thereof, the stem carries a dome having a peripheral skirt extending outwardly from the axis beyond the cylindrical surface of the stem. An annulus of corneal tissue has a central bore within which the stem is received, the peripheral skirt contacting and overlying a portion of the corneal annulus adjacent the bore. A portion of the annulus extends outwardly beyond the peripheral skirt for attachment to a surgically prepared cornea. A ring of polymeric material is received over the stem to capture between the ring and the skirt the corneal annulus.

Abstract: The present invention provides a method of corneal transplantation and a corneal structure resulting from such transplants. According to this method, a thickness of a patient's cornea is removed to define a bore through the cornea, this thickness of corneal tissue defining a cap consisting of an outer thickness of tissue and a plug of an inner thickness of the tissue. An ocular implant sized and shaped similarly to the plug is then placed within the bore and surgically attached. The cap of the patient's own tissue is then placed in the bore and surgically reattached. The patient's cornea may be marked before removal of the tissue and this marking may be used to properly reorient the cap upon placing it in the bore for reattachment. The corneal structure of the invention includes an ocular implant sized to fit closely within a bore through a patient's cornea, the implant being attached to the cornea, and a cap formed from an outer thickness of the patient's cornea.

Abstract: Prosthetic devices and methods are described that can be employed in replacing corneal endothelial tissue to allow the diseased or damaged corneal endothelial tissue to be replaced without replacing the outer layers of the patient's cornea and/or to replace the full thickness of the cornea in a manner resulting in less deformation of the outermost surface of the cornea (i.e. less astigmatism) than occurs with current full thickness transplant techniques.

Abstract: An implant prosthesis and method for replacing a full or partial thickness of a cornea. The prosthesis includes a transparent lens portion, and a carrier of preserved tissue, preferably cornea. The lens is attached to the carrier which in turn is adapted for attachment to the eye wall.

Abstract: The device includes two separately movable indicators for conveying different messages, such as "service needed" or "check please." The device includes first and second actuator pins for moving the first and second indicators relative to a vertical housing, which is mounted on a tray support placed on a table.

Abstract: A device and method for allowing fluid to flow from the interior of the eye into the nasolacrimal drainage system associated with the eye to relieve high intraocular pressure in the treatment of glaucoma. The method employs a flexible tube having one end extendable into the anterior chamber of the eye and having its other end in communication with the nasolacrimal drainage system of the eye. A one-way valve is provided within the tube to restrain liquid flow to a direction from the anterior chamber of the eye toward the lacrimal drainage system. The method includes the steps of inserting one end of the tube into the anterior chamber of the eye and inserting the other end of the tube into a portion of the nasolacrimal drainage system; aqueous humor is permitted to escape into the tube at the anterior chamber end, and flows outwardly into the passages of the nasolacrimal system. One or more one-way valve within the tube permit fluid flow only away from the anterior chamber.

Abstract: The disclosure relates to an infusion cannula for infusing fluids into various cavities of the eye. The cannula comprises a tube having first and second ends and a check valve therebetween for allowing fluid flow only toward the first end. The first end of the cannula secured within the eye and the second end of the cannula is attached to a fluid source.