Patents by Inventor Thomas C. Zebovitz

Thomas C. Zebovitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of 3-amino-substituted glycosylated bile acids
    Patent number: 5864022
    Abstract: The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Intermediates and related compounds are also disclosed. In particular, the present invention permits the conversion of cholic acid esters to the 3-amino-7,12-bis(glucosyl)cholic acid esters via an azide intermediate. Conditions for the purification and isolation of the desired product is also disclosed to provide an overall manufacturing process suitable for large-scale production.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: January 26, 1999
    Assignee: Intercardia, Inc.
    Inventors: Anna K. Chen, Ramesh Kakarla, Dashan Liu, Michael J. Sofia, Thomas C. Zebovitz
  • Process for the manufacture of 3-amino-substituted glycosylated bile acids
    Patent number: 5693770
    Abstract: The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Novel intermediates and related compounds are also disclosed. In particular, the present invention permits the conversion of cholic acid esters to the 3-amino-7,12-bis(glucosyl)cholic acid esters via an azide intermediate. Conditions for the purification and isolation of the desired product is also disclosed to provide an overall manufacturing process suitable for large-scale production.
    Type: Grant
    Filed: June 23, 1995
    Date of Patent: December 2, 1997
    Assignee: Transcell Technologies, Inc.
    Inventors: Anna K. Chen, Ramesh Kakarla, Dashan Liu, Michael J. Sofia, Thomas C. Zebovitz
  • Process for the manufacture of 3-amino-substituted glycosylated bile acids
    Patent number: 5585470
    Abstract: The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Novel intermediates and related compounds are also disclosed.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: December 17, 1996
    Assignee: Transcell Technologies, Inc.
    Inventors: Anna K. Chen, Ramesh Kakarla, Dashan Liu, Michael J. Sofia, Thomas C. Zebovitz