Patents by Inventor Thomas Carell

Thomas Carell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11442046
    Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: September 13, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Thomas Carell, Uwe Kobold, Dieter Heindl, Silvia Baecher, Andreas Leinenbach, Martin Rempt, Toni Pfaffeneder, Angie Kirchner, Olesea Kosmatchev, Rene Rahimoff, Sarah Schiffers, Markus Muller
  • Patent number: 11370756
    Abstract: The present disclosure relates to sulfoxide-based reagents suitable in the mass spectrometric determination of analyte molecules such as peptides as well as adducts of such reagents and analyte molecules and applications of the reagents and adducts. Further, the present disclosure relates to methods for the mass spectrometric determination of analyte molecules.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 28, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Thomas Carell
  • Patent number: 10751425
    Abstract: The present invention refers to the transfection of cells using a conjugate comprising at least one saccharide residue at least one nucleosidic component selected from nucleic acids, nucleosides and nucleotides. This conjugate is suitable for the transfection of prokaryotic and eukaryotic cells such as plant cells or mammalian cells including human cells with high efficacy. Thus, a new delivery vehicle for therapeutic molecules including antisense molecules, sRNA molecules, miRNA molecules, antagomirs or precursors of such molecules, as well as the therapeutic nucleosides or nucleotides, is provided. Further, a convenient strategy for developing new lines of plants that exhibit particular traits is provided.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: August 25, 2020
    Assignee: baseclick GmbH
    Inventor: Thomas Carell
  • Publication number: 20200199071
    Abstract: The present disclosure relates to sulfoxide-based reagents suitable in the mass spectrometric determination of analyte molecules such as peptides as well as adducts of such reagents and analyte molecules and applications of the reagents and adducts. Further, the present disclosure relates to methods for the mass spectrometric determination of analyte molecules.
    Type: Application
    Filed: March 6, 2020
    Publication date: June 25, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventor: Thomas Carell
  • Publication number: 20200041470
    Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.
    Type: Application
    Filed: July 24, 2019
    Publication date: February 6, 2020
    Inventors: Thomas Carell, Uwe Kobold, Dieter Heindl, Silvia Baecher, Andreas Leinenbach, Martin Rempt, Toni Pfaffeneder, Angie Kirchner, Olesea Kosmatchev, Rene Rahimoff, Sarah Schiffers, Markus Muller
  • Patent number: 9480752
    Abstract: The present invention refers to a conjugate comprising at least one polyunsaturated fatty acid residue, particularly an arachidonic acid residue, more particularly an anandamide (arachidonoyl ethanol amide) residue and covalently bound thereto at least one nucleosidic component selected from nucleic acids, nucleosides and nucleotides. This conjugate is suitable for the transfection of cells such as mammalian cells including human cells with high efficacy. Thus, a new delivery vehicle for therapeutic molecules including antisense molecules, siRNA molecules, miRNA molecules, antagomirs or precursors of such molecules, as well as the therapeutic nucleosides or nucleotides, is provided.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: November 1, 2016
    Assignee: Baseclick GmbH
    Inventor: Thomas Carell
  • Publication number: 20150209441
    Abstract: The present invention refers to a conjugate comprising at least one polyunsaturated fatty acid residue, particularly an arachidonic acid residue, more particularly an anandamide (arachidonoyl ethanol amide) residue and covalently bound thereto at least one nucleosidic component selected from nucleic acids, nucleosides and nucleotides. This conjugate is suitable for the transfection of cells such as mammalian cells including human cells with high efficacy. Thus, a new delivery vehicle for therapeutic molecules including antisense molecules, siRNA molecules, miRNA molecules, antagomirs or precursors of such molecules, as well as the therapeutic nucleosides or nucleotides, is provided.
    Type: Application
    Filed: July 10, 2013
    Publication date: July 30, 2015
    Inventor: Thomas Carell
  • Patent number: 9005892
    Abstract: The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: April 14, 2015
    Assignee: Baseclick GmbH
    Inventors: Thomas Carell, Anja Schwögler, Glenn A. Burley, Johannes Gierlich, Mohammad Reza Mofid
  • Publication number: 20130237697
    Abstract: The present invention relates to building blocks and methods for the efficient synthesis of 5-hydroxymethylcytosine-containing nucleic acids such as DNA or RNA.
    Type: Application
    Filed: November 11, 2011
    Publication date: September 12, 2013
    Applicant: LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
    Inventors: Thomas Carell, Martin Munzel
  • Publication number: 20120190838
    Abstract: The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples.
    Type: Application
    Filed: March 2, 2012
    Publication date: July 26, 2012
    Applicant: BASECLICK GMBH
    Inventors: Thomas CARELL, Anja SCHWOEGLER, Glenn A. BURLEY, Johannes GIERLICH, Mohammad Reza MOFID
  • Publication number: 20120172582
    Abstract: The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples.
    Type: Application
    Filed: March 2, 2012
    Publication date: July 5, 2012
    Applicant: BASECLICK GMBH
    Inventors: Thomas CARELL, Anja SCHWÖGLER, Glenn A. BURLEY, Johannes GIERLICH, Mohammad Reza MOFID
  • Publication number: 20120157327
    Abstract: The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples.
    Type: Application
    Filed: March 2, 2012
    Publication date: June 21, 2012
    Applicant: BASECLICK GMBH
    Inventors: Thomas CARELL, Anja SCHWÕEGLER, Glenn A. BURLEY, Johannes GIERLICH, Mohammad Reza MOFID
  • Patent number: 8193335
    Abstract: The present invention relates to methods for producing reporter molecules suitable for the detection of analytes, e.g. nucleic acids. Further, the present invention relates to methods and regions for detecting analytes.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 5, 2012
    Assignee: baseclick GmbH
    Inventors: Thomas Carell, Anja Schwögler
  • Publication number: 20120107943
    Abstract: The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples.
    Type: Application
    Filed: November 22, 2011
    Publication date: May 3, 2012
    Applicant: BASECLICK GMBH
    Inventors: Thomas CARELL, Anja SCHWOEGLER, Glenn A. BURLEY, Johannes GIERLICH, Mohammad Reza MOFID
  • Patent number: 8129315
    Abstract: The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: March 6, 2012
    Assignee: Baseclick GmbH
    Inventors: Thomas Carell, Anja Schwögler, Glenn A. Burley, Johannes Gierlich, Mohammad Reza Mofid
  • Publication number: 20100081137
    Abstract: The present invention relates to methods for producing reporter molecules suitable for the detection of analytes, e.g. nucleic acids. Further, the present invention relates to methods and regions for detecting analytes.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 1, 2010
    Inventors: Thomas Carell, Anja Schwogler
  • Publication number: 20100028894
    Abstract: The present invention refers to a detection method for analytes using the principle of black-and-white photography and to reagent kits for performing the method, furthermore applied this new technology to detect a biologically relevant sequence in the nanomolar range (femtomoles) in an application circumventing the necessity of a PCR. There are still numerous ways to optimize this methodology that is suitable for a large variety of applications in the genomic diagnostics and proteomics areas.
    Type: Application
    Filed: November 7, 2007
    Publication date: February 4, 2010
    Inventors: Thomas Carell, Anja Schwögler
  • Publication number: 20090215635
    Abstract: The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples.
    Type: Application
    Filed: April 28, 2006
    Publication date: August 27, 2009
    Applicant: BASF SE
    Inventors: Thomas Carell, Anja Schwögler, Glenn A. Burley, Johannes Gierlich, Mohammad Reza Mofid
  • Publication number: 20090087857
    Abstract: The present invention refers to a detection method for analytes using the principle of black-and-white photography and to reagent kits for performing the method, furthermore applied this new technology to detect a biologically relevant sequence in the nanomolar range (femtomoles) in an application circumventing the necessity of a PCR. There are still numerous ways to optimize this methodology that is suitable for a large variety of applications in the genomic diagnostics and proteomics areas.
    Type: Application
    Filed: April 26, 2007
    Publication date: April 2, 2009
    Inventors: Thomas Carell, Anja Schwögler
  • Patent number: 5877030
    Abstract: Methods for forming combinatorial libraries and the libraries produced thereby are provided. According to a preferred aspect of the invention, a plurality of core molecules are reacted with a plurality of different tool molecules to form a library of molecules having non-naturally occurring molecular diversity. The libraries are useful for identifying lead compounds which modulate the functional activity of a biological molecule. Protease inhibitors that have been isolated from the libraries also are disclosed.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: March 2, 1999
    Inventors: Julius Rebek, Jr., Thomas Carell, Edward A. Wintner