Abstract: The present invention provides compositions and methods related to equine live-attenuated influenza vaccines. In one aspect, the invention relates to a composition comprising a multivalent equine live-attenuated influenza vaccine comprising a first live-attenuated influenza virus expressing one or more antigens of a clade 1 H3N8 equine influenza virus; and a second live-attenuated influenza virus expressing one or more antigens of a clade 2 H3N8 equine influenza virus, wherein the second live-attenuated influenza virus expresses HA, NA, or a combination thereof of A/equine/Lancashire/1/2016 H3N8.

Abstract: Various implementations include open-ear headphones. In some cases, an open-ear headphone includes: an acoustic module for providing an audio output to an ear of a user; a battery housing; and a flexible arm physically and electrically coupling the acoustic module to the battery housing, the flexible arm including: a flexible printed circuit connecting the battery housing and the acoustic module, and a flexible material that encases at least some of the flexible printed circuit, where when worn, the acoustic module is located in a concha of the ear, the battery housing is located behind the ear, and the flexible arm passes over an outer side of at least one of at least one of an anti-helix, a helix, or a lobule of the ear.

Abstract: A flexible arm that is configured to be located between and physically and electrically connect an acoustic module of an open-ear headphone to a battery housing of the open-ear headphone. The flexible arm defines an original resting length and position between the acoustic module and the battery housing. The flexible arm includes a flexible printed circuit that extends through the entire original resting length of the flexible arm and comprises a conductor that is configured to carry electrical energy between the acoustic module and the battery housing, and a flexible material that encases at least some of the flexible printed circuit. The length of the flexible printed circuit within the flexible arm is greater than the original resting length of the flexible arm. The flexible printed circuit can thus better accommodate tension or compression on the flexible arm as the flexible arm is bent from its original resting position.

Abstract: A flexible arm that is configured to be located between and physically and electrically connect an acoustic module of an open-ear headphone to a battery housing of the open-ear headphone. The flexible arm defines an original resting length and position between the acoustic module and the battery housing. The flexible arm includes a flexible printed circuit that extends through the entire original resting length of the flexible arm and comprises a conductor that is configured to carry electrical energy between the acoustic module and the battery housing, and a flexible material that encases at least some of the flexible printed circuit. The length of the flexible printed circuit within the flexible arm is greater than the original resting length of the flexible arm. The flexible printed circuit can thus better accommodate tension or compression on the flexible arm as the flexible arm is bent from its original resting position.

Abstract: A flexible arm that is configured to be located between and physically and electrically connect an acoustic module of an open-ear headphone to a battery housing of the open-ear headphone. The flexible arm defines an original resting length and position between the acoustic module and the battery housing. The flexible arm includes a flexible printed circuit that extends through the entire original resting length of the flexible arm and comprises a conductor that is configured to carry electrical energy between the acoustic module and the battery housing, and a flexible material that encases at least some of the flexible printed circuit. The length of the flexible printed circuit within the flexible arm is greater than the original resting length of the flexible arm. The flexible printed circuit can thus better accommodate tension or compression on the flexible arm as the flexible arm is bent from its original resting position.

Abstract: A flexible arm that is configured to be located between and physically and electrically connect an acoustic module of an open-ear headphone to a battery housing of the open-ear headphone. The flexible arm defines an original resting length and position between the acoustic module and the battery housing. The flexible arm includes a flexible printed circuit that extends through the entire original resting length of the flexible arm and comprises a conductor that is configured to carry electrical energy between the acoustic module and the battery housing, and a flexible material that encases at least some of the flexible printed circuit. The length of the flexible printed circuit within the flexible arm is greater than the original resting length of the flexible arm. The flexible printed circuit can thus better accommodate tension or compression on the flexible arm as the flexible arm is bent from its original resting position.

Abstract: The present invention provides compositions and methods related to equine live-attenuated influenza vaccines.

Abstract: A modular audio system which includes an acoustic module configured to be removably engaged with a head-worn peripheral device. In some examples, the head-worn peripheral device is a pair of eyeglass frames and the acoustic module is configured to removably secure to a socket arranged on the inside face of the temples of the eyeglasses. The acoustic module can slidingly, pivotably, and/or magnetically engage with the socket such that, when secured, the acoustic module is configured to generate acoustic energy in the form of audible sound proximate a user's ear while the user is wearing the head-worn peripheral device. In other examples, the temples of the head-worn peripheral device are configured to slidingly engage with a sleeve, where the sleeve includes a pocket configured to slidingly engage with the acoustic module.

Abstract: The present invention provides compositions and methods related to equine live-attenuated influenza vaccines. In one aspect, the invention relates to a composition comprising a multivalent equine live-attenuated influenza vaccine comprising a first live-attenuated influenza virus expressing one or more antigens of a clade 1 H3N8 equine influenza virus; and a second live-attenuated influenza virus expressing one or more antigens of a clade 2 H3N8 equine influenza virus, wherein the second live-attenuated influenza virus expresses HA, NA, or a combination thereof of A/equine/Lancashire/1/2016 H3N8.

Abstract: A modular audio system which includes an acoustic module configured to be removably engaged with a head-worn peripheral device. In some examples, the head-worn peripheral device is a pair of eyeglass frames and the acoustic module is configured to removably secure to a socket arranged on the inside face of the temples of the eyeglasses. The acoustic module can slidingly, pivotably, and/or magnetically engage with the socket such that, when secured, the acoustic module is configured to generate acoustic energy in the form of audible sound proximate a user's ear while the user is wearing the head-worn peripheral device. In other examples, the temples of the head-worn peripheral device are configured to slidingly engage with a sleeve, where the sleeve includes a pocket configured to slidingly engage with the acoustic module.

Abstract: According to an aspect of the disclosure, a user input device is provided comprising a substrate configured to couple to a user, at least one sensing unit, the at least one sensing unit being coupled to the substrate and being configured to provide an output signal indicative of an amount of deformation of the substrate, and a controller coupled to the at least one sensing unit, the controller being configured to receive, from the at least one sensing unit, the output signal, and determine, based on the output signal, at least one gesture performed by the user.

Abstract: The present invention provides compositions and methods related to equine live-attenuated influenza vaccines.

Abstract: The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated equine influenza viruses having modifications to an equine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.

Abstract: The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated equine influenza viruses having modifications to an equine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.