Abstract: Disclosed herein are methods for the treatment of a patient having an ocular conditions such as age-related macular degeneration or diabetic macular edema through administration of a recombinant binding protein comprising an ankyrin repeat domain. In some embodiments, the composition may be administered every 8 weeks to every 16 weeks. In some embodiments, the patient being treated may be refractory to existing anti-VEGF therapies.

Abstract: Disclosed herein are methods for the treatment of a patient having an ocular conditions such as age-related macular degeneration or diabetic macular edema through administration of a recombinant binding protein comprising an ankyrin repeat domain. In some embodiments, the composition may be administered every 8 weeks to every 16 weeks. In some embodiments, the patient being treated may be refractory to existing anti-VEGF therapies.

Abstract: Disclosed herein are methods for the treatment of a patient having an ocular conditions such as age-related macular degeneration or diabetic macular edema through administration of a recombinant binding protein comprising an ankyrin repeat domain. In some embodiments, the composition may be administered every 8 weeks to every 16 weeks. In some embodiments, the patient being treated may be refractory to existing anti-VEGF therapies.

Abstract: Disclosed herein are methods for the treatment of a patient having an ocular conditions such as age-related macular degeneration or diabetic macular edema through administration of a recombinant binding protein comprising an ankyrin repeat domain. In some embodiments, the composition may be administered every 8 weeks to every 16 weeks. In some embodiments, the patient being treated may be refractory to existing anti-VEGF therapies.

Abstract: A simple interface may be provided that enables the user to define parameters for aggregation of a semi-additive measure. The interface may enable the user to designate a measure as a semi-additive measure and to pair the measure with an additive aggregation function. The interface may also enable the user to select non-additive dimensions and to pair each non-additive dimension with a corresponding aggregation function. One such aggregation function is a by account aggregation function, which enables each account in an account dimension to be aggregated across a corresponding non-additive dimension according to an associated account type.

Abstract: The present invention leverages MOLAP performance for ROLAP objects (dimensions, partitions and aggregations) by building, in a background process, a MOLAP equivalent of that object. When the background processing completes, queries are switched from ROLAP queries to MOLAP queries. When changes occur to relevant relational objects (such as tables that define content of OLAP objects), an OLAP object is switched back to a ROLAP mode, and all relevant caches are dropped while, as a background process, a new MOLAP equivalent is created.

Abstract: The present invention leverages MOLAP performance for ROLAP objects (dimensions, partitions and aggregations) by building, in a background process, a MOLAP equivalent of that object. When the background processing completes, queries are switched from ROLAP queries to MOLAP queries. When changes occur to relevant relational objects (such as tables that define content of OLAP objects), an OLAP object is switched back to a ROLAP mode, and all relevant caches are dropped while, as a background process, a new MOLAP equivalent is created.

Abstract: The present invention leverages MOLAP performance for ROLAP objects (dimensions, partitions and aggregations) by building, in a background process, a MOLAP equivalent of that object. When the background processing completes, queries are switched from ROLAP queries to MOLAP queries. When changes occur to relevant relational objects (such as tables that define content of OLAP objects), an OLAP object is switched back to a ROLAP mode, and all relevant caches are dropped while, as a background process, a new MOLAP equivalent is created.

Abstract: A method is described herein for causing an analytical database server to store query results in a memory. In the method, a first header element and a request to query an analytical database is received. The first header element indicates that a query result should be stored. The analytical database is queried according to the request, and the query result is stored. An identifier associated with the query result and a second header element corresponding to the identifier is then transmitted.

Abstract: The subject invention relates to systems and methods that extend the network data access capabilities of mark-up language protocols. In one aspect, a network data transfer system is provided. The system includes a protocol component that employs a computerized mark-up language to facilitate data interactions between network components, whereby the data interactions were previously limited or based on a statement command associated with the markup language. An extension component operates with the protocol component to support the data transactions, where the extension component supplies at least one other command from the statement command to facilitate the data interactions.

Abstract: The subject invention pertains to the integration of an object model and a multidimensional database query language such as MDX. In particular, multidimensional declarative query language entities can be exposed through objects in an object model. The object model enables generation and employment of procedural language functions, routines, or procedures that interact with multidimensional database data. This effectively provides an extension for multidimensional query languages. For example, procedures can be stored and invoked from a declarative language query. Furthermore, the object model disclosed herein can expose a context object to enable conditional procedures based on the context of execution.

Abstract: The subject invention relates to systems and methods that extend the network data access capabilities of mark-up language protocols. In one aspect, a network data modeling system is provided. The system includes a protocol component that employs a computerized mark-up language to facilitate data interactions between network components. An extension component operates with the protocol component to support the data transactions, where the extension component supplies various commands above standard network and database protocols. An object model is provided as a wrapper to the extensions in order to support various online and offline database development applications.

Abstract: The subject disclosure pertains to swift and efficient modification of multidimensional database cubes. For example, support is provided for the addition of custom groupings of dimension members. In one instance, the custom groupings can provide an intermediate dimension level for drill down and/or drill up or roll-up between a level with few members and a level with numerous members. A separate dimensional attribute or level can be created and a group defined comprising or mapping a set or collection of discrete members. Furthermore, the custom grouping can be realized without the delay associated with rebuilding, reprocessing or reloading dimensional structures.

Abstract: An improved drive mechanism for a windmill has: (a) a drive chain driven into movement by a wind wheel shaft driven into rotation by wind movement against a wind wheel; (b) a drive chain sprocket driven by the drive chain and coupled to a force chain sprocket to correspondingly drive a force chain; (c) a chain pin coupled at one position to the force chain and also coupled to a captive slide; and (d) a pump rod connected to the slide and driven an equal distance in each direction by the driven slide in order to convert full mechanical force equally on both the full upstroke and the full downstroke of the pump rod. The improved drive mechanism improves the efficiency of the power cycle by transitioning to the full upstroke with only a minimal dwell on either end of the stroke for transition to movement in the opposite direction. Full mechanical force can thus be applied equally on both the full upstroke and the full downstroke.

Abstract: A simple interface may be provided that enables the user to define parameters for aggregation of a semi-additive measure. The interface may enable the user to designate a measure as a semi-additive measure and to pair the measure with an additive aggregation function. The interface may also enable the user to select non-additive dimensions and to pair each non-additive dimension with a corresponding aggregation function. One such aggregation function is a by account aggregation function, which enables each account in an account dimension to be aggregated across a corresponding non-additive dimension according to an associated account type.

Abstract: A tie for forming a plurality of elongate objects into a bundle and for holding a pair of objects together. The tie of the present invention comprises an elongate strap, a locking head joined to one end of the strap for receiving the other end of the strap and roller means disposed entirely within the locking head for lockingly engaging the strap. The head includes a strap entry face, a strap exit face and a strap-receiving aperture extending therebetween and further includes a floor and a roof which diverge in the direction of the exit face. The locking head also has retention means for retaining the roller means inside the head.