Patents by Inventor Thomas Coolidge

Thomas Coolidge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating peripheral vascular disease
    Publication number: 20060030528
    Abstract: The present invention relates to methods of treating intermittent claudication comprising administering glucagon-like peptide-1 (GLP-1) molecules to subjects suffering therefrom.
    Type: Application
    Filed: August 5, 2005
    Publication date: February 9, 2006
    Applicant: Amylin Pharmaceuticals, Inc.
    Inventors: David Hathaway, Thomas Coolidge
  • Treatment of hibernating myocardium with a GLP-1 peptide
    Publication number: 20050096276
    Abstract: Hibernating myocardium is characterized by viable myocardium with impaired function due to localized reduced perfusion. Hibernating myocytes retain cellular integrity, but cannot sustain high-energy requirements of contraction. High plasma levels of catecholamines, such as norepinepherine, are believed to be predictive of mortality from hibernating myocardium. Likewise, high levels of catecholamines lead to cardiomyopathy in patients with diabetes. GLP-1 reduces plasma norepinepherine levels, and it thus is useful in a method of treating hibernating myocardium or diabetic cardiomyopathy.
    Type: Application
    Filed: December 8, 2004
    Publication date: May 5, 2005
    Inventors: Thomas Coolidge, Mario Ehlers