Abstract: An injury treatment system includes a negative pressure source and a dressing pneumatically communicable with the negative pressure source. The dressing includes a negative pressure therapy component configured to expose an anatomical structure to a negative pressure when the negative pressure therapy component is applied to the anatomical structure and in response to operation of the negative pressure source. The dressing also includes an immobilization component coupled to the negative pressure therapy system, wherein the immobilization component is configured to transition from a flexible state to an inflexible state in response to the operation of the negative pressure source.

Abstract: An injury treatment system includes a negative pressure source and a dressing pneumatically communicable with the negative pressure source. The dressing includes a negative pressure therapy component configured to expose an anatomical structure to a negative pressure when the negative pressure therapy component is applied to the anatomical structure and in response to operation of the negative pressure source. The dressing also includes an immobilization component coupled to the negative pressure therapy system, wherein the immobilization component is configured to transition from a flexible state to an inflexible state in response to the operation of the negative pressure source.

Abstract: Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.

Abstract: Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.

Abstract: Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.

Abstract: The present disclosure relates to compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the invention include aza-peptide aldehyde and ketone compositions that inhibit proteases. The disclosed compounds, pharmaceutically acceptable salts, pharmaceutically acceptable derivatives, prodrugs, or combinations thereof can be used to treat disease or pathological conditions related to the activity of proteases associated with a specific disease or condition.

Abstract: Disclosed herein is a microstructured tool having a microstructured layer on a base layer. The microstructured layer is made from an aromatic acrylate polymer that is a reaction product of an oligomer and a radiation curable diluent, the aromatic acrylate polymer having a ratio of aromatic to aliphatic carbons of less than about 1:1, the oligomer comprising a multifunctional acrylate monomer or an acrylate functionalized oligomer. The microstructured layer has a microstructured surface having one or more features. The base layer may be metal, polymer, ceramic, or glass. Also disclosed herein is a method of making the microstructured tool using laser ablation. The microstructured tool may be used to make articles suitable for use in optical applications.

Abstract: Methods of aligning flexible molds, segmented mold and frame apparatus, as well as methods of making microstructured articles (e.g. PDP back panels) are described.

Abstract: Molds, methods of making molds, as well as methods of making microstructured (e.g. barrier rib) articles such has display panels are described.

Abstract: A method of making a microstructured article such as barrier ribs for a display panel is described. The method employs a template to provide a discrete coating of a curable material.

Abstract: Described are methods of making microstructured (e.g., barrier ribs) articles employing a transfer apparatus.

Abstract: Methods of making (e.g. barrier rib) microstructures are described. The methods employ providing a discrete mold comprised of a flexible (e.g. polymeric) film on a roller.

Abstract: In one embodiment the present invention relates to microstructured articles (e.g., barrier ribs formed by a method that comprises providing at least one discrete coating of slurry on a transfer sheet).