Abstract: A pH system that is able to compensate for variations in pressure and conductivity is disclosed. The system includes a pH sensor, a pressure sensor and optionally a conductivity sensor, the outputs of each are transmitted to a controller. The controller multiplies a compensation coefficient by the difference in pressure between the measured pressure and a threshold pressure. This result is then added to the measured pH value. Further, the compensation coefficient is a function of the conductivity of the solution. In some instances, the compensation coefficient is calculated by raising the conductivity to a power and multiplying that result by a constant. This pH system may be incorporated into various bioprocessing systems, such as multi-column chromatography systems and viral inactivation systems.

Abstract: The disclosure herein relates to a flow path comprising half clamps 1 having an interior surface surrounding a flexible tubing 3 connection with a barb adapter 3, when assembled may be placed within a clamshell reduce or prevent deformation of the flexible tubing.

Abstract: The disclosure herein relates to a flow path comprising half clamps 1 having an interior surface surrounding a flexible tubing 3 connection with a barb adapter 3, when assembled may be placed within a clamshell reduce or prevent deformation of the flexible tubing.

Abstract: An incubation chamber that may be provided in modular form in order to provide flexibility in flow rate and/or residence time of a product stream is disclosed. Assemblies including such incubation chambers for purification of biomolecules are also disclosed, as are methods for biomolecule purification, and in particular, methods for virus inactivation in an incubation chamber or in a plurality of incubation chambers arranged in series.

Abstract: A probe chamber that includes a holder having a bore capable of holding a sensor or probe; a chamber housing having a central bore in fluid communication with the bore of the holder, wherein the chamber housing can be joined with the holder; and a measurement chamber in fluid communication with the central bore, wherein the measurement chamber comprises a gate, an inlet and an outlet and is capable of receiving a probe tip or sensor tip. Methods for calibrating a probe or sensor are also disclosed.

Abstract: A static mixer (100), comprising a static mixer housing, having an inlet port (120) for receiving a fluid, a channel (104) in fluid communication with the inlet port (120), a raised rib along a perimeter of the channel (104), a flow splitter for splitting the fluid into a first stream (106a) and a second stream (106b) within channels, a second flow splitter for splitting the first stream (106a) into a third stream (110a) and a fourth stream (110b) within channels and a third flow splitter for splitting the second stream (106b) into a fifth stream (110c) and a sixth stream (110d) within channels, a first T-style junction for rejoining and mixing the third stream and the fourth stream within a channel (112a), a second T-style junction for rejoining and mixing the fifth stream and the sixth stream within a channel (112b), and a third T-style junction for rejoining and mixing the streams; and a plastic film, the plastic film sealed to the raised rib, forming a static mixer (100) capable of mixing the fluid while