Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: The disclosure relates to carrier particle-drug conjugates, including nanoparticle drug conjugates (NDC), that can be used in the delivery of a drug to a biological target (e.g., for targeted delivery of a cytotoxic drug to a cancer cell or tumor). Also disclosed are self-immolative linkers and linker-payload conjugates suitable for use in a carrier particle drug conjugate, and methods of making the same, and methods for treating cancer.

Abstract: A system is provided for the generation and management of Non-Fungible Tokens (NFTs) for supporting an institution is provided. The system has a processor for generating at least one NFT, the NFT being associated with at least one artwork. The NFT includes at least a first set of coding identifying the at least one artwork, at least a second set of coding setting a first allocation of funds from an initial sale of said NFT to a first patron to said institution for said at least one artwork; and at least a third set of coding setting a second allocation of funds from a subsequent sale of the NFT, by a first patron to a second patron, to the institution for the at least one artwork. The NFT is configured to be sellable on an ongoing basis, such that for each subsequent sale of the NFT from the purchase by the second patron, and including all subsequent purchases by additional patrons, results in at least a portion of the subsequent sales being diverted to the institution.

Abstract: This disclosure relates to methods of functionalizing a nanoparticle, e.g., for conjugation to a targeting ligand and/or payload moiety, such as for the production of a nanoparticle drug conjugate (NDC).

Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: Provided herein are recombinant nucleic acid molecules, nucleic acid constructs, fusion enzymes, transformed host cells, and methods for making aroma compounds alpha-ionone or beta-ionone.

Abstract: Disclosed is a contact lens drying apparatus (1702, 1702) configured to dry a lens container (903) that is attached to the apparatus in a drying configuration, the apparatus comprising a controller (106), drying engagement means (904) for removably engaging the lens container (903), wherein the drying engagement means (904) disposes the lens container (903) in an orientation that reduces ingress of airborne contaminants, and a heating element (107), wherein the controller (106) is configured to direct the heating element (107) to dry the engaged lens container (903) thereby significantly reducing microbial activity in the container.

Abstract: An improved power distribution unit substation, having a plurality of differing voltage rated main breaker cells, encased within a single housing is disclosed. The improved power distribution substation saves considerable floor space as compared to prior art substations. One embodiment houses a plurality of main breaker cells in a single housing. In this embodiment, a low voltage main breaker cell is vertically positioned above a plurality of medium voltage main breaker cells. Alternatively, a medium voltage main breaker cell is vertically positioned above a plurality of low or medium voltage cells. Improved single-ended and double-ended power distribution substations are disclosed that offer cost and floor space savings as compared to prior art substations.

Abstract: A method and apparatus for reducing intercolor bleed using pixel spot size control to improve print quality is provided. The method includes printing pixels having a first spot size in an image region having a boundary between a first color portion and a second color portion of the image by ejecting first sized ink drops from the printhead nozzles, and printing border pixels having spot sizes smaller than the first spot size in the image region by ejecting smaller ink drops from the printhead nozzles, wherein the smaller ink drops are smaller than the first sized ink drops. A printing system is provided having means for printing pixels in the region having the first spot size and means for printing border pixels having spot sizes smaller than the first spot size.

Abstract: An improved power distribution unit substation, having a plurality of differing voltage rated main breaker cells, encased within a single housing is disclosed. The improved power distribution substation saves considerable floor space as compared to prior art substations. One embodiment houses a plurality of main breaker cells in a single housing. In this embodiment, a low voltage main breaker cell is vertically positioned above a plurality of medium voltage main breaker cells. Alternatively, a medium voltage main breaker cell is vertically positioned above a plurality of low or medium voltage cells. Improved single-ended and double-ended power distribution substations are disclosed that offer cost and floor space savings as compared to prior art substations.

Abstract: An improved optically coupled isolator uses a glass layer in combination with layers of junction coat material between the emitter and detector to provide greater electrical isolation while preventing potential ionic contamination in the glass from reaching the detector and causing a deterioration in its operating characteristics. The isolator is assembled using standard semiconductor processing techniques so that the cost of manufacture is not substantially increased.