Abstract: In some embodiments, apparatuses and methods are provided herein useful to contain and dispense a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a control device, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some embodiments, a dispensing bottle includes a non-removable closure cap with a tamper evident feature that indicates whether the cap was previously opened. By one approach, the dispensing bottle includes discontinuous threads on a bottle neck and ratchet projections on a closure cap that engage the discontinuous thread(s) to prevent or inhibit manual removal of the cap from the bottle.

Abstract: In some embodiments, apparatuses and methods provided herein are useful for dispensing a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a flip top, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some configurations, the base has a central opening through which the fluid exits and an internal shaft with a non-planar end surface opposite the central opening. In some configurations, the non-planar end surface and the disk define channels between the mixing chamber and the internal shaft. In some embodiments, the disk includes a central opening, a plurality of partial annular openings through a planar surface of the disk, and projections extending into the mixing chamber.

Abstract: In some embodiments, apparatuses and methods provided herein are useful for dispensing a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a flip top, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some configurations, the base has a central opening through which the fluid exits and an internal shaft with a non-planar end surface opposite the central opening. In some configurations, the non-planar end surface and the disk define channels between the mixing chamber and the internal shaft. In some embodiments, the disk includes a central opening, a plurality of partial annular openings through a planar surface of the disk, and projections extending into the mixing chamber.

Abstract: A subsea wet-mateable connector handle has a handle part, a bushing support ring, a resilient bushing, a connector mount and a securing pin. A method of manufacturing a subsea wet-mateable connector handle includes cutting a handle part from a sheet of inherently corrosion resistant metal plate by a two-dimensional cutting process. A bushing support ring and a bushing are assembled onto a limb extending from the handle part. A connector mount is mounted to the bushing and the connector mount and bushing are fixed to the handle part with the securing pin.

Abstract: Embodiments of the present disclosure include a system for depositing a layered nanolaminate alloy including a controller for an electrodeposition process that includes a waveform synthesizer circuit configured to generate a complex waveform signal corresponding to a desired electrodeposition waveform to be output from an electrodeposition power supply. The controller also includes a synthesizer control circuit configured to control the waveform synthesizer circuit. Based at least in part on a recipe having information related to the electrodeposition process, the synthesizer control circuit controls the generation of the complex waveform signal by modulating in real-time at least one of a waveform shape, a frequency, an amplitude, an offset, a slew, a wavelength, a phase, a velocity, and a derivative of the complex waveform signal. The controller further includes a controller output circuit configured to transmit the complex waveform signal to an input of the electrodeposition power supply.

Abstract: Provided are B cell-activating factor receptor (BAFF-R)-binding molecules, in particular, to human antibodies specific for BAFF-R, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for BAFF-R. Also provided are CARs which contain extracellular binding domains that bind to BAFF-R and B-lymphocyte antigen CD19 (CD19), genetically engineered cells expressing such CARs, and uses thereof in adoptive cell therapy.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to contain and dispense a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a control device, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some embodiments, a dispensing bottle includes a non-removable closure cap with a tamper evident feature that indicates whether the cap was previously opened. By one approach, the dispensing bottle includes discontinuous threads on a bottle neck and ratchet projections on a closure cap that engage the discontinuous thread(s) to prevent or inhibit manual removal of the cap from the bottle.

Abstract: A tamper-evident closure is provided and includes a base and a lid. The lid is movable between a closed and an open position with respect to the base. The closure includes a tamper-evident member which is initially provided on or by the base with the closure in an unopened condition. The tamper-evident member is released from the base when the lid is initially moved to the open position and is then retained by the lid.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to contain and dispense a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a control device, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some embodiments, a dispensing bottle includes a non-removable closure cap with a tamper evident feature that indicates whether the cap was previously opened. By one approach, the dispensing bottle includes discontinuous threads on a bottle neck and ratchet projections on a closure cap that engage the discontinuous thread(s) to prevent or inhibit manual removal of the cap from the bottle.

Abstract: A connector assembly (30) for use in subsea environments comprises a plug (32) and a receptacle (34) generally arranged about a longitudinal axis (36). The plug (32) comprises a plug body (38) through which a down hole gauge cable (40) extends. The receptacle (34) comprises a receptacle body (42) and through which a supply cable (44) extends for connection with the down hole gauge cable (40). The plug (32) and the receptacle (34) are secured together via a securing nut (48). The plug (32) and the receptacle (34) are in contact and form a primary seal (70). A rotary test adaptor (46) is located radially outwardly of and is sealed against an outer surface (110) of the plug body (38) and is located radially inwardly of and is sealed against a radially inner surface (108) of the securing nut (48).

Abstract: In some embodiments, apparatuses and methods provided herein are useful for dispensing a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a flip top, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some configurations, the base has a central opening through which the fluid exits and an internal shaft with a non-planar end surface opposite the central opening. In some configurations, the non-planar end surface and the disk define channels between the mixing chamber and the internal shaft. In some embodiments, the disk includes a central opening, a plurality of partial annular openings through a planar surface of the disk, and projections extending into the mixing chamber.

Abstract: Aspects of the present invention relate to the recombinant production of a mature complement system protein. Certain embodiments of the present invention relate to recombinant production of fully mature human complement Factor I protein (CFI). Included herein are details of an expression vector with which to recombinantly express fully mature human CFI from mammalian cells. Further disclosed are chromatography steps with which to purify recombinantly expressed CFI. Certain aspects of the present invention relate to the use of an expression system in gene therapy and the like. Certain embodiments of the present invention relate to use of said vector as a medicament, for example for use in the treatment of complement-mediated disorders.

Abstract: A subsea plug connector part for a subsea wet-mateable connector includes a receptacle connector part and a plug connector part, the plug connector part has a plug back end, a plug front end and an interface. The interface includes a first cold separable joint element at one end. The plug front end includes a second cold separable joint element. The first cold separable joint element and second cold separable joint element are adapted to join the interface to the plug front end.

Abstract: In some embodiments, apparatuses and methods provided herein are useful for dispensing a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a flip top, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some configurations, the base has a central opening through which the fluid exits and an internal shaft with a non-planar end surface opposite the central opening. In some configurations, the non-planar end surface and the disk define channels between the mixing chamber and the internal shaft. In some embodiments, the disk includes a central opening, a plurality of partial annular openings through a planar surface of the disk, and projections extending into the mixing chamber.

Abstract: A tamper-evident closure is provided and comprises a base and a lid. The lid is movable between a closed and an open position with respect to the base. The closure comprises a tamper-evident member which is initially provided on or by the base with the closure in an unopened condition. The tamper-evident member is released from the base when the lid is initially moved to the open position and is then retained by the lid.

Abstract: A subsea wet-mateable connector handle has a handle part, a bushing support ring, a resilient bushing, a connector mount and a securing pin. A method of manufacturing a subsea wet-mateable connector handle includes cutting a handle part from a sheet of inherently corrosion resistant metal plate by a two-dimensional cutting process. A bushing support ring and a bushing are assembled onto a limb extending from the handle part. A connector mount is mounted to the bushing and the connector mount and bushing are fixed to the handle part with the securing pin.

Abstract: In some embodiments, apparatuses and methods provided herein are useful for dispensing a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a flip top, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some configurations, the base has a central opening through which the fluid exits and an internal shaft with a non-planar end surface opposite the central opening. In some configurations, the non-planar end surface and the disk define channels between the mixing chamber and the internal shaft. In some embodiments, the disk includes a central opening, a plurality of partial annular openings through a planar surface of the disk, and projections extending into the mixing chamber.

Abstract: A high-gain, wide-angle, multi-beam, multi-frequency beamforming lens antenna that includes a Luneburg lens with at least one planar interface in the southern hemisphere of the Luneburg lens and a planar ultrawideband modular antenna (PUMA array) structure. The PUMA array structure is connected to at least one of the planar interfaces of the Luneburg lens and is configured to function as a feed network to illuminate cells of the Luneburg lens simultaneously.

Abstract: In some embodiments, apparatuses and methods provided herein are useful for dispensing a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a flip top, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some configurations, the base has a central opening through which the fluid exits and an internal shaft with a non-planar end surface opposite the central opening. In some configurations, the non-planar end surface and the disk define channels between the mixing chamber and the internal shaft. In some embodiments, the disk includes a central opening, a plurality of partial annular openings through a planar surface of the disk, and projections extending into the mixing chamber.