Abstract: An aircraft that has a blade position control system (BPCS). The BPCS includes an actuator, a multilobe component configured for at least one of longitudinal movement along a mast axis as a function of actuation of the actuator and rotational movement relative to the mast axis as a function of actuation of the actuator. Movement of the multilobe component selectively restricts at least one of pitch movement and folding of a plurality of rotor blades.

Abstract: Embodiments are directed to a blade lock comprising a fold lock adapted to prevent folding of a rotor blade in a fold-lock position and to allow folding of the rotor blade in a pitch-lock position. The blade lock further comprises a pitch lock adapted to allow pitch movement of a rotor blade in a fold-lock position and to prevent pitch movement of the rotor blade in the pitch-lock position. A spring-loaded link pivotally connects both the fold lock and the pitch lock and is adapted to provide passive, overcenter locking in the fold-lock position. An actuator is coupled to the pitch lock and is adapted to move the pitch lock and the fold lock between the fold-lock and pitch-lock positions.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: A rotor-hub flap-measurement system includes a rotor hub operable to flap relative to a main-rotor axis, a flap-linkage arm, a first end of the flap-linkage arm rotatably coupled to the rotor hub, the flap-linkage arm responsive to flapping of the rotor hub, and a magneto-resistive sensor system rotatably coupled to a second end of the flap-linkage arm and responsive to movement of the flap-linkage arm.

Abstract: A touch sensing apparatus is provided comprising: a light transmissive panel that defines a touch surface, a plurality of light emitters and detectors arranged along a perimeter of the light transmissive panel, a plurality of optical components arranged along the perimeter of the light transmissive panel, wherein the light emitters are arranged to emit a respective beam of emitted light and the optical components are configured to direct the emitted light to a path across the light transmissive panel. Optionally, optical components comprise a light guide arranged to receive light from the light emitters through a first surface and couple out light travelling in the light guide to the touch surface through a second surface. The second surface may be diffusively transmissive. The light guide may further comprise a reflective surface configured to internally reflect light travelling in the light guide from the first surface to the diffusive surface.

Abstract: A universal-joint cross assembly includes a cross. Four compression rings are mounted at terminal positions of the cross. Each of the four compression rings is positioned at a 90° interval relative to adjacent ones of the four compression rings. The universal-joint cross assembly includes four inner balls. Each of the four inner balls is fixed to one of the four compression rings and forms a portion of a spherical bearing.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: An exemplary blade lock for a tiltrotor aircraft to enable and disable a folding degree of freedom and a pitching degree of freedom of a rotor blade assembly includes a link pivotally connected to a lever and a bellcrank, where the link is in a center position when the lever is in a locked position disabling the folding degree of freedom and the lever is secured in the locked position when the link is positioned in an over-center position.

Abstract: A rotor-hub-flap anisotropic-sensor system includes a rotor hub, a plurality of anisotropic-sensor arrangements interoperably coupled to the rotor hub and operable to measure flapping of the rotor hub, a plurality of rotor blades connected to the rotor hub, and at least one flight control computer interoperably coupled to the plurality of anisotropic-sensor arrangements.

Abstract: A lockout system for an aircraft having a rotor assembly. The lockout system includes a drive shaft coupled to and rotatable with the rotor assembly, a nonrotating airframe structure disposed proximate the drive shaft and a lock assembly having first and second lock members. The first lock member is rotatable with the drive shaft and includes a plurality of bearing assemblies. The second lock member is coupled to the nonrotating airframe structure and includes a cradle having a plurality of asymmetric slots each with a leading ramp and a trailing stop. The lock assembly has a disengaged position in which rotation of the drive shaft is allowed and an engaged position in which each of the bearing assemblies is seated within one of the asymmetric slots to prevent rotation of the drive shaft. The lock assembly is actuatable between the engaged and disengaged positions.

Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: A teeter flap lock for an aircraft may include at least one pair of diametrically positioned teeter flap lock plates extending from a rotor teetering hinge, spaced apart from a rotor mast of the aircraft. A teeter flap lock block is positioned about the rotor mast and is configured to fit between the teeter flap lock plates and the rotor mast. The teeter flap lock block fits between and contacts the teeter flap lock plates in an engaged position, and is movable between the engaged position and a disengaged position relative to the teeter flap lock plates. The teeter flap lock enables flapping of rotors coupled to the rotor mast via the teetering hinge when the teeter flap lock block is in the disengaged position and disables flapping of the rotors when the teeter flap lock block is in the engaged position.

Abstract: A gimbal joint may employ a plurality of wear sleeves, each disposed between a pin or pin receptive bore of a first structure and a corresponding bore or pin of a second structure and between another pin or bore of the second structure and a corresponding bore or pin of a third structure. Each of these structures may be adapted to rotate in a single plane, with one structure adapted to also tilt about a first axis, and one other structure adapted to tilt about a second axis. Each integral flanged wear sleeve may comprise a right circular hollow cylindrical body portion, which may be interiorly sized to be retained on one of the pins and externally sized to be retained in one of the pin receptive bores, and a flange portion may radiate from one end of the cylindrical body portion.

Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: A lockout system for an aircraft having a rotor assembly. The lockout system includes a drive shaft coupled to and rotatable with the rotor assembly, a nonrotating airframe structure disposed proximate the drive shaft and a lock assembly having first and second lock members. The first lock member is rotatable with the drive shaft and includes a plurality of bearing assemblies. The second lock member is coupled to the nonrotating airframe structure and includes a cradle having a plurality of asymmetric slots each with a leading ramp and a trailing stop. The lock assembly has a disengaged position in which rotation of the drive shaft is allowed and an engaged position in which each of the bearing assemblies is seated within one of the asymmetric slots to prevent rotation of the drive shaft. The lock assembly is actuatable between the engaged and disengaged positions.

Abstract: A system for retaining a folded proprotor blade in flight. The system includes a mounting plate, a first arm coupled to the mounting plate at an acute angle relative to the mounting plate, and a first deformable pad affixed to the first arm and adapted to contact the folded proprotor blade.

Abstract: A touch sensing apparatus is provided comprising: a light transmissive panel that defines a touch surface, a plurality of light emitters and detectors arranged along a perimeter of the light transmissive panel, a plurality of optical components arranged along the perimeter of the light transmissive panel, wherein the light emitters are arranged to emit a respective beam of emitted light and the optical components are configured to direct the emitted light to a path across the light transmissive panel. Optionally, optical components comprise a light guide arranged to receive light from the light emitters through a first surface and couple out light travelling in the light guide to the touch surface through a second surface. The second surface may be diffusively transmissive. The light guide may further comprise a reflective surface configured to internally reflect light travelling in the light guide from the first surface to the diffusive surface.

Abstract: Embodiments are directed to a rotor hub assembly comprising a yoke configured to attach rotor blades thereto, a single Hooke's joint configured to attach to, and transmit forces between, a mast and the yoke, and a spherical bearing coupled between the yoke and the mast. Two pillow blocks couple the single Hooke's joint to the yoke. An adapter sleeve is attached to the pillow blocks and is positioned to surround the spherical bearing. The adapter sleeve extends between the single Hooke's joint and the mast. A hub lock extension is attached to the yoke. The hub lock extension is configured to receive a hub lock that prevents gimballing of the yoke when engaged.