Abstract: The invention pertains to a pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, wherein the prodrug has an octanol/water partition coefficient of at least 0, for use in a method of shaping a mammalian body by modulation of subcutaneous fat tissue. The invention further pertains to cosmetic and therapeutic application of such prodrugs, such as their use in methods of shaping a mammalian body by locally modulating subcutaneous fat tissue. The invention also pertains to the prodrugs themselves, as well as to methods of making these prodrugs.

Abstract: The invention pertains to a pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, wherein the prodrug has an octanol/water partition coefficient of at least 0, for use in a method of shaping a mammalian body by modulation of subcutaneous fat tissue. The invention further pertains to cosmetic and therapeutic application of such prodrugs, such as their use in methods of shaping a mammalian body by locally modulating subcutaneous fat tissue. The invention also pertains to the prodrugs themselves, as well as to methods of making these prodrugs.

Abstract: New aporphine derivatives are disclosed which have formula (I) and the physiologically acceptable salts thereof. Said derivatives may be used for the treatment of Parkinson's disease, hemicrania, restless legs syndrome (RLS), sexual dysfunction in men and women, hyperprolactemia and psychotic disorders, and/or evaluation of Parkinson's disease. Processes for the preparation of such derivates are also disclosed.

Abstract: The present invention is, in one embodiment, an apparatus for placing an insert within a nested group of taco shells. The insert placement apparatus comprises a vertical shaft, a horizontal shaft, a first pillow block, a second pillow block, a vacuum cup, a horizontal timing belt, an air cylinder, and a servomotor. The vacuum cup is adapted to transport the insert. The first pillow block has a bore therethrough for receiving the horizontal shaft. The second pillow block is supported off of the first pillow block and has a bore therethrough for receiving the vertical shaft. The vacuum cup is suspended off of the vertical shaft. The horizontal belt is routed around a drive pulley and a second pulley and is interconnected to the first pillow block. The servomotor is interconnected to the drive pulley. The servomotor causes the timing belt to displace the first pillow block along the horizontal shaft, thereby causing the vacuum cup to displace horizontally.

Abstract: New aporphine derivatives are disclosed which have formula (I) and the physiologically acceptable salts thereof. Said derivatives may be used for the treatment of Parkinson's disease, hemicrania, restless legs syndrome (RLS), sexual dysfunction in men and women, hyperprolactemia and psychotic disorders, and/or evaluation of Parkinson's disease. Processes for the preparation of such derivatives are also disclosed.

Abstract: New aporphine derivatives are disclosed which have formula (I) and the physiologically acceptable salts thereof. Said derivatives may be used for the treatment of Parkinson's disease, hemicrania, restless legs syndrome (RLS), sexual dysfunction in men and women, hyperprolactemia and psychotic disorders, and/or evaluation of Parkinson's disease. Processes for the preparation of such derivatives are also disclosed.

Abstract: The present invention relates to the use of compounds and compositions of compounds having serotonin reuptake inhibiting activity and 5-HT2C antagonistic, partial agonistic or inverse agonistic activity for the treatment of depression and other affective disorders. The combined serotonin reuptake inhibiting effect and the 5-HT2C antagonistic, partial agonistic or inverse agonistic effect may reside within the same chemical compound or in two different chemical compounds.

Abstract: The present invention is, in one embodiment, an apparatus for placing an insert within a nested group of taco shells. The insert placement apparatus comprises a vertical shaft, a horizontal shaft, a first pillow block, a second pillow block, a vacuum cup, a horizontal timing belt, an air cylinder, and a servomotor. The vacuum cup is adapted to transport the insert. The first pillow block has a bore therethrough for receiving the horizontal shaft. The second pillow block is supported off of the first pillow block and has a bore therethrough for receiving the vertical shaft. The vacuum cup is suspended off of the vertical shaft. The horizontal belt is routed around a drive pulley and a second pulley and is interconnected to the first pillow block. The servomotor is interconnected to the drive pulley. The servomotor causes the timing belt to displace the first pillow block along the horizontal shaft, thereby causing the vacuum cup to displace horizontally.

Abstract: The invention relates to the use of a compound, which is a serotonin reuptake inhibitor, and another compound, which is a GABAB receptor antagonist, inverse agonist or partial agonist for the preparation of a pharmaceutical composition for the treatment of depression, anxiety disorders and other affective disorders, such as generalized anxiety disorder, panic anxiety, obsessive compulsive disorder, acute stress disorder, post traumatic stress disorder and social anxiety disorder, eating disorders such as bulimia, anorexia and obesity, phobias, dysthymia, premenstrual syndrome, cognitive disorders, impulsive control disorders, attention deficit hyperactivity disorder, drug abuse or any other disorder responsive to serotonin reuptake inhibitors.

Abstract: This disclosure relates to a method of specifically decorating selected mammalian chromosomes and of detecting, identifying and and/or quantitating selected individual chromosomes, by means of chromosomal in situ suppression (CISS) hybridization. The method is useful in analyzing cells for the occurrence of chromosomes, chromosome fragments or chromosome aberrations.

Abstract: New aporphine derivatives are disclosed which have formula (I) and the physiologically acceptable salts thereof. Said derivatives may be used for the treatment of Parkinson's disease, hemicrania, restless legs syndrome (RLS), sexual dysfunction in men and women, hyperprolactemia and psychotic disorders, and/or evaluation of Parkinson's disease. Processes for the preparation of such derivatives are also disclosed.

Abstract: The present invention is, in one embodiment, an apparatus for placing an insert within a nested group of taco shells. The insert placement apparatus comprises a vertical shaft, a horizontal shaft, a first pillow block, a second pillow block, a vacuum cup, a horizontal timing belt, an air cylinder, and a servomotor. The vacuum cup is adapted to transport the insert. The first pillow block has a bore therethrough for receiving the horizontal shaft. The second pillow block is supported off of the first pillow block and has a bore therethrough for receiving the vertical shaft. The vacuum cup is suspended off of the vertical shaft. The horizontal belt is routed around a drive pulley and a second pulley and is interconnected to the first pillow block. The servomotor is interconnected to the drive pulley. The servomotor causes the timing belt to displace the first pillow block along the horizontal shaft, thereby causing the vacuum cup to displace horizontally.

Abstract: A rotary cutter assembly (11) includes a rotary cutter (74) rotated by a motor (76) through a drive including pulleys (250, 264) and a belt (326) inside of a combination guard and belt tensioner assembly (260). The rotary cutter (74) includes a cutter head (82) having integral blade holders (92) which slideably receive knives (90) in a channel (230) each having a detent (236) which is received in an aperture (91) in the knife (90) so that no fasteners or moveable parts are provided for holding the knives (90) and adjustment of the knives (90) is not needed or allowed. Guard quarters (266, 314) and a guard half (268) are moveable between closed and open positions and are held in the closed position by a single latch (325). The guard half (268) includes an idler (300) which tensions the belt (326) in the closed position.

Abstract: New aporphine derivatives are disclosed which have formula (I) and the physiologically acceptable salts thereof. Said derivatives may be used for the treatment of Parkinson's disease, hemicrania, restless legs syndrome (RLS), sexual dysfunction in men and women, hyperprolactemia and psychotic disorders, and/or evaluation of Parkinson's disease. Processes for the preparation of such derivatives are also disclosed.

Abstract: A method of determining the relative number of nucleic acid sequences in test cells which provides for a high resolution during comparative genomic hybridization by keeping all components separate from each other and selecting target nucleic acids which have a high resolution capability for determining genomic imbalances in the test cells and which facilitate a screening of the test cells for over- or under-expression of individual genes.

Abstract: The present invention relates to a method of purifying a set of specific DNA molecules to be used in DNA-DNA hybridisations, as well as to DNA probes containing less than 2% Cot-1 DNA.

Abstract: A method of determining the relative number of nucleic acid sequences in test cells which provides for a high resolution during comparative genomic hybridization by keeping all components separate from each other and selecting target nucleic acids which have a high resolution capability for determining genomic imbalances in the test cells and which facilitate a screening of the test cells for over- or under-expression of individual genes.

Abstract: This disclosure relates to a method of specifically decorating selected mammalian chromosomes and of detecting, identifying and and/or quantitating selected individual chromosomes, by means of chromosomal in situ suppression (CISS) hybridization. The method is useful in analyzing cells for the occurrence of chromosomes, chromosome fragments or chromosome aberrations.

Abstract: A method of determining the relative number of nucleic acid sequences in test cells which provides for a high resolution during comparative genomic hybridization by keeping all components separate from each other and selecting target nucleic acids which have a high resolution capability for determining genomic imbalances in the test cells and which facilitate a screening of the test cells for over- or under-expression of individual genes.

Abstract: In a method for the application of cuts, perforations and/or microlesions to biological material, such as cell agglomerates, individual cells or chromosomes, by means of laser pulses fed into a microscope, the laser pulses are focussed to a cross-section which is limited by diffraction phenomena, and the nth order diffraction maxima (n=1, 2, 3, . . . ) of the laser pulses are used to apply the cuts.