Patents by Inventor Thomas Cushman Ransohoff

Thomas Cushman Ransohoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of tissue plasminogen activator (tPA)
    Patent number: 7074560
    Abstract: A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are disclosed. Also disclosed are methods whereby additional ligands having desirable preselected binding and release (elution) characteristics may be isolated, permitting the development of tailored ligands to meet the purification problems presented by any particular feed stream containing tPA.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: July 11, 2006
    Assignee: Dyax Corp.
    Inventors: John Moore Maclennan, Robert Charles Ladner, Thomas Cushman Ransohoff
  • Purification of tissue plasminogen activator (tPA)
    Publication number: 20030162942
    Abstract: A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are disclosed. Also disclosed are methods whereby additional ligands having desirable preselected binding and release (elution) characteristics may be isolated, permitting the development of tailored ligands to meet the purification problems presented by any particular feed stream containing tPA.
    Type: Application
    Filed: July 11, 2002
    Publication date: August 28, 2003
    Inventors: John Moore Maclennan, Robert Charles Ladner, Thomas Cushman Ransohoff
  • Purification of tissue plasminogen activator (TPA)
    Patent number: 6462172
    Abstract: A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are disclosed. Also disclosed are methods whereby additional ligands having desirable preselected binding and release (elution) characteristics may be isolated, permitting the development of tailored ligands to meet the purification problems presented by any particular feed stream containing tPA.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: October 8, 2002
    Inventors: John Moore Maclennan, Robert Charles Ladner, Thomas Cushman Ransohoff
  • Polypeptides that bind to tissue plasminogen activator (tPA)
    Patent number: 6084062
    Abstract: A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are disclosed.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: July 4, 2000
    Assignee: Dyax Corp.
    Inventors: John Moore Maclennan, Robert Charles Ladner, Thomas Cushman Ransohoff