Patents by Inventor Thomas D. Gaffney

Thomas D. Gaffney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5891688
    Abstract: The present invention exploits the discovery that certain single base changes in the gacA gene coding sequence, which result in certain single amino acid changes in the encoded GacA protein, render it LemA-independent. The present invention therefore provides DNA that encodes mutant GacA proteins that do not require phosphorylation by LemA in order to be active as transcriptional activators.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: April 6, 1999
    Assignee: Novartis Finance Corporation
    Inventors: Thomas D. Gaffney, Stephen T. Lam
  • Patent number: 5804693
    Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 8, 1998
    Assignee: Novartis Finance Corporation
    Inventors: Thomas D. Gaffney, John A. Ryals, Leslie B. Friedrich, Scott J. Uknes, Eric R. Ward, Helmut Kessmann, Bernardus T. Vernooij
  • Patent number: 5756087
    Abstract: Strains of Pseudomonas have been genetically engineered to have enhanced biocontrol properties. The strains of the invention are particularly effective against plant pathogenic fungi such as species of Rhizoctonia and Pythium, because the strains produce enhanced amounts of antifungal metabolites such as pyrrolnitrin that are active against these fungal pathogens. Both the genetically modified biocontrol strains and the antifungal metabolites can be used as active agents for biocontrol compositions.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: May 26, 1998
    Assignee: Novartis Finance Corporation
    Inventors: James M. Ligon, Dwight S. Hill, Stephen T. Lam, Thomas D. Gaffney, Nancy Torkewitz
  • Patent number: 5710031
    Abstract: Gene activating sequences which activate the expression of other bacterial genes, which are latent or expressed at low levels, are provided. The gene activating sequences confer the ability to produce several metabolites and may be transferred to bacterial strains. The transformed biocontrol agents are active to inhibit the growth of the fungal pathogens.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 20, 1998
    Assignee: Novartis Finance Corporation
    Inventors: Thomas D. Gaffney, Stephen T. Lam, James M. Ligon, Dwight Steven Hill, Jeffrey I. Stein
  • Patent number: 5686282
    Abstract: Gene activating sequences which activate the expression of other bacterial genes, which are latent or expressed at low levels, are provided. The gene activating sequences confer the ability to produce several metabolites and may be transferred to bacterial strains. The transformed biocontrol agents are active to inhibit the growth of the fungal pathogens.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 11, 1997
    Assignee: Novartis Finance Corporation
    Inventors: Stephen T. Lam, Thomas D. Gaffney
  • Patent number: 5686283
    Abstract: Gene activating sequences which activate the expression of other bacterial genes, which are latent or expressed at low levels, are provided. The gene activating sequences confer the ability to produce several metabolites and may be transferred to bacterial strains. The transformed biocontrol agents are active to inhibit the growth of the fungal pathogens.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 11, 1997
    Assignee: Novartis Finance Corporation
    Inventors: Thomas D. Gaffney, Stephen T. Lam
  • Patent number: 5670350
    Abstract: Gene activating sequences which activate the expression of other bacterial genes, which are latent or expressed at low levels, are provided. The gene activating sequences confer the ability to produce several metabolites and may be transferred to bacterial strains. The transformed biocontrol agents are active to inhibit the growth of the fungal pathogens.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: September 23, 1997
    Assignee: Novartis Finance Corporation
    Inventors: Thomas D. Gaffney, Stephen T. Lam, Dwight Steven Hill, Jeffrey I. Stein, James M. Ligon
  • Patent number: 5397697
    Abstract: The invention is a method for identifying and cloning bacterial genes that are responsive to the presence of a plant host, comprising mutating a bacterial culture with a transposon containing a promoterless marker gene, exposing the bacterial mutants to root exudates, other plant-derived substances or plants, and identifying mutants that have a transposon-associated gene inducible by the plant. These mutants may be used to clone and characterize the promoters and the associated wild-type bacterial genes responsive to the plant.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: March 14, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Stephen T. Lam, Daniel M. Ellis, Thomas D. Gaffney
  • Patent number: 4948242
    Abstract: A day/night vehicle rearview mirror assembly comprises a casing carrying a prismatic mirror, the casing being pivotally mounted on a mounting plate. Preferably, the casing and mirror are driven between a full reflectance position and partial reflectance position by a rack and pinion assembly having interengaging gear teeth extending between a d.c. motor operated drive shaft and a portion of the casing. Alternately, a friction coupling extends between the drive shaft and casing. A noise and vibration reducing coupling are provided in the drive shaft while appropriate glare sensing circuitry and/or switches control operation of the reversible motor and, thus, the reflectance position of the mirror.
    Type: Grant
    Filed: March 17, 1989
    Date of Patent: August 14, 1990
    Assignee: Donnelly Mirrors Limited
    Inventors: John P. Desmond, Thomas P. Flynn, Thomas D. Gaffney, James P. Campbell, Parick J. Lawlor, John J. McCormack, Molyneux, Keith W.
  • Patent number: 4886960
    Abstract: The invention provides an automatic rearview mirror system (10) for a vehicle comprising a reflective element (22) actuatable between at least two different reflective conditions. The system includes a forward light sensor (11) to detect light forward of the vehicle and a rear light sensor (12) to detect light rearward of the mirror. A control circuit means (14,16) is coupled to the reflective element (22), the forward light sensor (11) and the rear light sensor (12). The control circuit causes the reflective element to assume a reflective state dependent upon the output of the forward and rear light sensors. The control circuit includes means for modifying the output of the forward light sensor (11) to cause a reduction in the sensitivity of the mirror.
    Type: Grant
    Filed: April 5, 1988
    Date of Patent: December 12, 1989
    Assignee: Donnelly Mirrors Limited
    Inventors: Keith W. Molyneux, Thomas D. Gaffney