Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, CY, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A machine for forming a container from a blank includes a mandrel mounted to a frame. The mandrel includes a first side, an opposite second side, and an external shape complementary to an internal shape of at least a portion of the container. The machine also includes a first presser arm, a folding arm, and a second presser arm each coupled to the frame. The first presser arm is positionable generally proximate the first side of the mandrel and is configured to wrap a first portion of the blank about the mandrel. The folding arm is positionable at least generally proximate the second side of the mandrel and is configured to wrap a second portion of the blank about the mandrel. The second presser arm is disposed generally proximate the first presser arm and is configured to wrap a third portion of the blank about the mandrel.

Abstract: A method for forming a container from a blank assembly including a tray blank and lid blank includes folding a first portion of the blank assembly about at least a first face of a first mandrel to form a partially formed container, and transferring the partially formed container towards a second mandrel using a transfer assembly that extends through the first face of the first mandrel. The method also includes transferring the partially formed container from the first mandrel to the second mandrel along a pair of guide rails extending between the first mandrel and the second mandrel, wrapping a second portion of the blank assembly about at least a first face of the second mandrel to form the container, wherein the first face of the second mandrel opposes the first face of the first mandrel with respect to a vertical direction, and ejecting the container from the second mandrel.

Abstract: A method for forming a container from a blank assembly including a tray blank and lid blank includes folding a first portion of the blank assembly about at least a first face of a first mandrel to form a partially formed container, and transferring the partially formed container towards a second mandrel using a transfer assembly that extends through the first face of the first mandrel. The method also includes transferring the partially formed container from the first mandrel to the second mandrel along a pair of guide rails extending between the first mandrel and the second mandrel, wrapping a second portion of the blank assembly about at least a first face of the second mandrel to form the container, wherein the first face of the second mandrel opposes the first face of the first mandrel with respect to a vertical direction, and ejecting the container from the second mandrel.

Abstract: A machine for forming a container from a blank assembly including a tray blank and lid blank includes a frame, a mandrel assembly mounted to the frame, a pre-folding assembly, and a glue panel presser assembly. The mandrel assembly includes a first mandrel and a second mandrel positioned downstream from the first mandrel. The first mandrel has an external shape complementary to an internal shape of at least a first portion of the container, and the second mandrel has an external shape complementary to an internal shape of at least a second portion of the container. The pre-folding assembly is configured to fold a first portion of the blank assembly around the first mandrel to form a partially formed container. The glue panel presser assembly includes a first presser plate configured to form a first manufacturer joint, and a second presser plate configured to form a second manufacturer joint.

Abstract: A machine for forming a container from a blank assembly including a tray blank and lid blank includes a frame, a mandrel assembly mounted to the frame, a pre-folding assembly, and a glue panel presser assembly. The mandrel assembly includes a first mandrel and a second mandrel positioned downstream from the first mandrel. The first mandrel has an external shape complementary to an internal shape of at least a first portion of the container, and the second mandrel has an external shape complementary to an internal shape of at least a second portion of the container. The pre-folding assembly is configured to fold a first portion of the blank assembly around the first mandrel to form a partially formed container. The glue panel presser assembly includes a first presser plate configured to form a first manufacturer joint, and a second presser plate configured to form a second manufacturer joint.

Abstract: A machine for forming a container from a blank includes a mandrel mounted to a frame. The mandrel includes a first side, an opposite second side, and an external shape complementary to an internal shape of at least a portion of the container. The machine also includes a first presser arm, a folding arm, and a second presser arm each coupled to the frame. The first presser arm is positionable generally proximate the first side of the mandrel and is configured to wrap a first portion of the blank about the mandrel. The folding arm is positionable at least generally proximate the second side of the mandrel and is configured to wrap a second portion of the blank about the mandrel. The second presser arm is disposed generally proximate the first presser arm and is configured to wrap a third portion of the blank about the mandrel.

Abstract: A machine for forming a container from a blank includes a mandrel mounted to a frame. The mandrel includes a first side, an opposite second side, and an external shape complementary to an internal shape of at least a portion of the container. The machine also includes a first presser arm, a folding arm, and a second presser arm each coupled to the frame. The first presser arm is positionable generally proximate the first side of the mandrel and is configured to wrap a first portion of the blank about the mandrel. The folding arm is positionable at least generally proximate the second side of the mandrel and is configured to wrap a second portion of the blank about the mandrel. The second presser arm is disposed generally proximate the first presser arm and is configured to wrap a third portion of the blank about the mandrel.

Abstract: A machine for forming a container from a blank of sheet material including a glue panel and an overlap panel includes a frame, a mandrel mounted to the frame, a glue panel folder assembly, and a glue panel presser assembly. The mandrel has an external shape complimentary to an internal shape of at least a portion of the container. The glue panel folder assembly includes an actuator and a glue panel folding member operatively coupled to the actuator. The actuator is configured to cause the glue panel folding member to move in a curvilinear path of motion, contact the glue panel, and move the glue panel into at least partial contact with the mandrel. The glue panel presser assembly is configured to press the overlap panel into face-to-face contact with the glue panel to form a manufacturer joint of the container.

Abstract: A machine for forming a container from a blank of sheet material including a glue panel and an overlap panel includes a frame, a mandrel mounted to the frame, a glue panel folder assembly, and a glue panel presser assembly. The mandrel has an external shape complimentary to an internal shape of at least a portion of the container. The glue panel folder assembly includes an actuator and a glue panel folding member operatively coupled to the actuator. The actuator is configured to cause the glue panel folding member to move in a curvilinear path of motion, contact the glue panel, and move the glue panel into at least partial contact with the mandrel. The glue panel presser assembly is configured to press the overlap panel into face-to-face contact with the glue panel to form a manufacturer joint of the container.

Abstract: A machine for forming a container from a blank of sheet material including a glue panel and an overlap panel includes a frame, a mandrel mounted to the frame, a glue panel folder assembly, and a glue panel presser assembly. The mandrel has an external shape complimentary to an internal shape of at least a portion of the container. The glue panel folder assembly includes an actuator and a glue panel folding member operatively coupled to the actuator. The actuator is configured to cause the glue panel folding member to move in a curvilinear path of motion, contact the glue panel, and move the glue panel into at least partial contact with the mandrel. The glue panel presser assembly is configured to press the overlap panel into face-to-face contact with the glue panel to form a manufacturer joint of the container.

Abstract: A machine for forming a container from a blank assembly including a tray blank and lid blank includes a frame, a mandrel assembly mounted to the frame, a pre-folding assembly, and a glue panel presser assembly. The mandrel assembly includes a first mandrel and a second mandrel positioned downstream from the first mandrel. The first mandrel has an external shape complimentary to an internal shape of at least a first portion of the container, and the second mandrel has an external shape complimentary to an internal shape of at least a second portion of the container. The pre-folding assembly is configured to fold a first portion of the blank assembly around the first mandrel to form a partially formed container. The glue panel presser assembly includes a first presser plate configured to form a first manufacturer joint, and a second presser plate configured to form a second manufacturer joint.

Abstract: A machine for forming a container from a blank assembly including a tray blank and lid blank includes a frame, a mandrel assembly mounted to the frame, a pre-folding assembly, and a glue panel presser assembly. The mandrel assembly includes a first mandrel and a second mandrel positioned downstream from the first mandrel. The first mandrel has an external shape complimentary to an internal shape of at least a first portion of the container, and the second mandrel has an external shape complimentary to an internal shape of at least a second portion of the container. The pre-folding assembly is configured to fold a first portion of the blank assembly around the first mandrel to form a partially formed container. The glue panel presser assembly includes a first presser plate configured to form a first manufacturer joint, and a second presser plate configured to form a second manufacturer joint.

Abstract: A machine for forming a container from a blank assembly including a tray blank and lid blank includes a frame, a mandrel assembly mounted to the frame, a pre-folding assembly, and a glue panel presser assembly. The mandrel assembly includes a first mandrel and a second mandrel positioned downstream from the first mandrel. The first mandrel has an external shape complementary to an internal shape of at least a first portion of the container, and the second mandrel has an external shape complementary to an internal shape of at least a second portion of the container. The pre-folding assembly is configured to fold a first portion of the blank assembly around the first mandrel to form a partially formed container. The glue panel presser assembly includes a first presser plate configured to form a first manufacturer joint, and a second presser plate configured to form a second manufacturer joint.

Abstract: A method of forming a container from a blank of sheet material using a machine is provided. The blank includes a bottom panel, two side panels, two end panels, and a reinforcing panel assembly extending from a first side panel. The machine includes a hopper station, a corner post forming station, and a plunger station. The method includes rotating the reinforcing panel assembly upwardly toward the first side panel as the blank is transported from the hopper station to the corner post forming station, forming a corner wall and a reinforcing end tab by folding reinforcing panels about fold lines as the blank is transported through the corner post forming station, rotating the side panels and the end panels to be substantially perpendicular to the bottom panel by directing the blank through the plunger station, and coupling the reinforcing end tab to an end panel to form the container.

Abstract: A blank for forming a container is provided. The blank includes a plurality of side panels coupled together, the plurality of side panels including at least a first minor panel, and a first intermediate panel extending from a side edge of the first minor panel. The blank also includes a first bottom corner flap extending from a bottom edge of the first intermediate panel, wherein the first bottom corner flap includes a free edge including a first portion, and a first bottom minor flap extending from a bottom edge of the first minor panel, wherein the first bottom minor flap includes a free edge including a first portion. When the container is formed from the blank, the first portion of the free edge of the first bottom corner flap engages the first portion of the free edge of the first bottom minor flap in an edge-to-edge relationship.

Abstract: A machine for forming a container from a blank of sheet material includes a frame, a mandrel assembly mounted to the frame, a pre-folding assembly, and a transfer assembly. The mandrel assembly includes a first mandrel and a second mandrel. The first mandrel has an external shape complementary to an internal shape of at least a first portion of the container. The second mandrel is positioned downstream from the first mandrel, and has an external shape complementary to an internal shape of at least a second portion of the container. The pre-folding assembly is configured to fold a first portion of the blank around the first mandrel to form a partially formed container. The first portion of the blank corresponds to the first portion of the container. The transfer assembly is for transferring the partially formed container from the first mandrel to the second mandrel.

Abstract: A container configured to be selectively moved between a substantially flat position and a deployed position is provided. The container includes a first blank of sheet material for forming side walls of the container, and a second blank of sheet material for forming a bottom wall of the container. The first blank having an interior surface and an opposing exterior surface, a top edge and a bottom edge. The first blank includes a first side panel, a second side panel, a third side panel, a fourth side panel, a fifth side panel, and a sixth side panel wherein each of the side panels are coupled across a fold line. The first blank also includes end flaps extending from the bottom edge of each of the side panels wherein at least two of the end flaps includes a tab joint. The second blank having a plurality of side edges equal to a number of side panels of the first blank, each side edge having a width substantially equal to a width of the side panels of the first blank.

Abstract: A machine for forming a container from a blank includes a mandrel mounted to a frame. The mandrel includes a first side, an opposite second side, and an external shape complementary to an internal shape of at least a portion of the container. The machine also includes a first presser arm, a folding arm, and a second presser arm each coupled to the frame. The first presser arm is positionable generally proximate the first side of the mandrel and is configured to wrap a first portion of the blank about the mandrel. The folding arm is positionable at least generally proximate the second side of the mandrel and is configured to wrap a second portion of the blank about the mandrel. The second presser arm is disposed generally proximate the first presser arm and is configured to wrap a third portion of the blank about the mandrel.

Abstract: A machine for forming a container from a blank of sheet material includes a base, a frame coupled for rotation about the base, and a plurality of box-forming stations coupled to the frame. Each box-forming station includes a mandrel coupled to the frame. The mandrel includes a bottom face having two pairs of opposing edges, a pair of opposing side faces, and a pair of opposing end faces. Each box-forming station also includes a first pair of opposing presses each configured to be moved into close proximity to a respective end face, and a second pair of opposing presses each configured to be moved into close proximity to a respective side face. Each box-forming station additionally includes at least one manually operable mechanism configured to control a position of a first press from among the first pair of opposing presses and the second pair of opposing presses.