Patents by Inventor Thomas D. Hurley

Thomas D. Hurley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeutic methods
    Patent number: 9320722
    Abstract: Described herein are compositions and methods for the treatment of cancer, and in particular cancers characterized by a high level of ALD3H1 activity, which is associated with chemoresistance to cancer chemotherapeutic agents that are degraded by ALD3H1. The compositions described herein act as competitive inhibitors of ALD3H1 and thereby reduce breakdown of chemotherapeutics by this enzyme, and increase their efficacy for cancer treatment.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: April 26, 2016
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Thomas D. Hurley
  • COMPOSITIONS OF ALDH1A1 INHIBITORS AND METHODS OF USE IN TREATING CANCER
    Publication number: 20150306108
    Abstract: The present invention provides inhibitors of ALDH1A1 activity which have substantially no effect on either ALDH2 or ALDH3A1. Compositions and methods of use, as well as methods to treat cancer using the ALDH1A1 inhibitors, are also provided.
    Type: Application
    Filed: January 30, 2015
    Publication date: October 29, 2015
    Inventors: Thomas D. Hurley, Daniela Matei
  • NOVEL REGULATORS OF ALDEHYDE DEHYDROGENASE ALDH3A1 AND RELATED THERAPEUTIC METHODS
    Publication number: 20150202169
    Abstract: Described herein are compositions and methods for the treatment of cancer, and in particular cancers characterized by a high level of ALD3H1 activity, which is associated with chemoresistance to cancer chemotherapeutic agents that are degraded by ALD3H1. The compositions described herein act as competitive inhibitors of ALD3H1 and thereby reduce breakdown of chemotherapeutics by this enzyme, and increase their efficacy for cancer treatment.
    Type: Application
    Filed: September 26, 2014
    Publication date: July 23, 2015
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Thomas D. Hurley
  • Crystal structure of aldehyde dehydrogenase and methods of use thereof
    Patent number: 8124389
    Abstract: The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general terms, the method comprises computationally identifying a compound that binds to an ALDH polypeptide, using the atomic coordinates.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: February 28, 2012
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Indiana University Research and Technology Corporation
    Inventors: Che-Hong Chen, Daria Mochly-Rosen, Thomas D. Hurley
  • Crystal Structure of Aldehyde Dehydrogenase and Methods of Use Thereof
    Publication number: 20120028287
    Abstract: The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general terms, the method comprises computationally identifying a compound that binds to an ALDH polypeptide, using the atomic coordinates.
    Type: Application
    Filed: October 10, 2011
    Publication date: February 2, 2012
    Inventors: Che-Hong CHEN, Daria MOCHLY-ROSEN, Thomas D. HURLEY
  • CRYSTAL STRUCTURE OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF
    Publication number: 20090280516
    Abstract: The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general terms, the method comprises computationally identifying a compound that binds to an ALDH polypeptide, using the atomic coordinates.
    Type: Application
    Filed: May 4, 2009
    Publication date: November 12, 2009
    Inventors: Che-Hong Chen, Daria Mochly-Rosen, Thomas D. Hurley